期刊
FRONTIERS IN ONCOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.884423
关键词
colorectal cancer; immunotherapy; immune checkpoint inhibitor; natural products; immunomodulation
类别
资金
- National Nature Science Foundation of China [81874206, 82104466]
- Shanghai Frontiers Science Center of Disease and Syndrome Biology of Inflammatory Cancer Transformation [2021KJ03-12]
- Shanghai Rising-Star Program [20QA1409300]
- Program for Young Eastern Scholar at Shanghai Institutions of Higher Learning [QD2019034]
Colorectal cancer is a common cancer that poses a threat to human health. Immunotherapy is widely used in cancer treatment, but most colorectal cancer patients are not responsive to it. Therefore, developing an effective combination therapy is a goal in cancer research. Natural products, with their diverse immunomodulatory effects, have the potential to be used in comprehensive cancer treatment options.
Colorectal cancer (CRC) is a common cancer of the digestive system that endangers human health. Immunotherapy is widely used in the treatment of patients with cancer. Some patients with dMMR/MSI-H CRC benefit from treatments that use immune checkpoint inhibitors, but most CRC patients are not sensitive to immunotherapy. Furthermore, internal resistance and immune escape lead to a reduced immunotherapy response. Therefore, the development of an effective combination therapy to improve the response rate to immunotherapy is a goal of cancer research. Natural products are potential candidates for comprehensive cancer treatments due to their wide range of immunomodulatory effects through multifactorial underlying mechanisms. In this review, we summarize the challenges in the treatment of CRC and assess the immunomodulatory effects of natural products and their active components. Our work suggests that natural products represent potential options for combined CRC immunotherapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据