4.6 Article

Exosomal CD44 Transmits Lymph Node Metastatic Capacity Between Gastric Cancer Cells via YAP-CPT1A-Mediated FAO Reprogramming

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

Ievgenia Pastushenko et al.

Summary: This study reveals that mutation of the FAT1 gene promotes tumor initiation, progression, invasiveness, stemness, and metastasis. Loss of function of FAT1 activates a CAMK2-CD44-SRC axis while inactivates EZH2, playing important roles in the expression of YAP1 and ZEB1.

NATURE (2021)

Review Biochemistry & Molecular Biology

CD44 and Tumor-Derived Extracellular Vesicles (TEVs). Possible Gateway to Cancer Metastasis

Rafal Szatanek et al.

Summary: Cancer metastasis involves complex interactions between various cell types and the tumor microenvironment, with tumor cells releasing proteins and nucleic acids through extracellular vesicles to facilitate dissemination. This process plays a crucial role in tumor progression and escape from immune surveillance.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Oncology

Exosomal proteins: Key players mediating pre-metastatic niche formation and clinical implications (Review)

Mei Wang et al.

Summary: The concept of pre-metastatic niche sheds light on the molecular mechanisms of tumor metastasis, with exosomes playing a crucial role in this process. Malignant tumor-derived exosomes selectively load metastasis-associated proteins, which facilitate site-specific metastasis through various mechanisms. These exosomal proteins hold great potential in predicting organ-directed metastasis, prognosis, and cancer therapy.

INTERNATIONAL JOURNAL OF ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

Lymph node metastasis-derived gastric cancer cells educate bone marrow-derived mesenchymal stem cells via YAP signaling activation by exosomal Wnt5a

Mei Wang et al.

Summary: The study found that LNM-GCs specifically educated BM-MSCs via secretory exosomes, with exosomal Wnt5a identified as a key protein. Exosomes enriched with Wnt5a induced YAP dephosphorylation in BM-MSCs, while those lacking Wnt5a had the opposite effect. Inhibition of the YAP signaling pathway blocked the reprogramming of BM-MSCs by LNM-GC exosomes and serum exosomes.

ONCOGENE (2021)

Article Reproductive Biology

Exosome-mediated transfer of CD44 from high-metastatic ovarian cancer cells promotes migration and invasion of low-metastatic ovarian cancer cells

Xiameng Shen et al.

Summary: Tumor-derived exosomes play important roles in promoting migration and invasion of ovarian cancer cells. CD44, transferred through exosomes, influences the metastatic phenotype of cancer cells and may be a potential therapeutic target for ovarian cancer.

JOURNAL OF OVARIAN RESEARCH (2021)

Review Oncology

Fatty acid oxidation: driver of lymph node metastasis

Mao Li et al.

Summary: Fatty acid oxidation is an emerging hallmark of cancer metabolism and may play a role in the formation of lymph node metastasis. Targeting FAO for therapy could present innovative possibilities for treating late-stage cancer patients.

CANCER CELL INTERNATIONAL (2021)

Review Oncology

Role of Extracellular Vesicles on Cancer Lymphangiogenesis and Lymph Node Metastasis

Linlin Wang et al.

Summary: Studies have shown that various cells in the tumor microenvironment release extracellular vesicles (EVs) encapsulating different molecules, which can be taken up by lymph endothelial cells (LECs) to regulate tumor lymphangiogenesis. EVs may serve as biomarkers for tumor lymph node metastasis and hold potential for anti-tumor lymphangiogenesis therapy.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Tumor-derived exosomal BCYRN1 activates WNT5A/VEGF-C/VEGFR3 feedforward loop to drive lymphatic metastasis of bladder cancer

Hanhao Zheng et al.

Summary: In patients with lymph node metastatic bladder cancer, lncRNA BCYRN1 was found to be significantly upregulated in urinary exosomes and associated with BCa LN metastasis. BCYRN1 enhances lymphatic metastasis of BCa by activating Wnt/β-catenin signaling and promoting VEGF-C secretion. Blocking VEGFR3 can impair BCYRN1-induced LN metastasis.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Article Biochemistry & Molecular Biology

Exosomal S100A4 derived from highly metastatic hepatocellular carcinoma cells promotes metastasis by activating STAT3

Haoting Sun et al.

Summary: Intercellular cross-talk in cancer progression and metastasis involves exosomes released by tumor cells, which play a crucial role in promoting metastasis potential. Specifically, exosomal S100A4 derived from highly metastatic hepatocellular carcinoma (HCC) cells was found to significantly enhance the invasion and metastasis of low metastatic HCC cells, serving as a potential prognostic marker and therapeutic target for HCC metastasis.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Medicine, Research & Experimental

Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells

Xinxin Yuan et al.

Summary: Exosomes derived from breast cancer cells, particularly SCP28 cells, play a crucial role in promoting osteoclast differentiation and activation, contributing to the accelerated formation of a microenvironment favorable for bone metastasis. Specifically, the exosomal miR-21 from SCP28 cells regulates PDCD4 protein levels to facilitate osteoclastogenesis, indicating its potential as a diagnostic and therapeutic target for breast cancer bone metastasis.

THERANOSTICS (2021)

Review Endocrinology & Metabolism

CPT1A-mediated Fat Oxidation, Mechanisms, and Therapeutic Potential

Isabel R. Schlaepfer et al.

ENDOCRINOLOGY (2020)

Article Medicine, Research & Experimental

Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer

Changhao Chen et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Biochemistry & Molecular Biology

Inhibition of carnitine palmitoyl transferase 1A-induced fatty acid oxidation suppresses cell progression in gastric cancer

Liqiang Wang et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

Review Oncology

Exosomes play roles in sequential processes of tumor metastasis

Keyu Li et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

Article Oncology

Colorectal cancer exosomes induce lymphatic network remodeling in lymph nodes

Bo Sun et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

Article Multidisciplinary Sciences

Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation

Choong-kun Lee et al.

SCIENCE (2019)

Article Cell Biology

Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis

Goncalo Rodrigues et al.

NATURE CELL BIOLOGY (2019)

Article Cardiac & Cardiovascular Systems

YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis

Hyunsoo Cho et al.

CIRCULATION RESEARCH (2019)

Article Medicine, Research & Experimental

CPT1A regulates breast cancer-associated lymphangiogenesis via VEGF signaling

Yiquan Xiong et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Medicine, Research & Experimental

Standard CD44 modulates YAP1 through a positive feedback loop in hepatocellular carcinoma

Zhenhai Fan et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Oncology

The biology and role of CD44 in cancer progression: therapeutic implications

Chen Chen et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

Article Multidisciplinary Sciences

The role of fatty acid β-oxidation in lymphangiogenesis

Brian W. Wong et al.

NATURE (2017)

Article Multidisciplinary Sciences

Tumour exosome integrins determine organotropic metastasis

Ayuko Hoshino et al.

NATURE (2015)

Article Cell Biology

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Bruno Costa-Silva et al.

NATURE CELL BIOLOGY (2015)

Article Cell Biology

CD44 acts through RhoA to regulate YAP signaling

Yuchen Zhang et al.

CELLULAR SIGNALLING (2014)

Review Medicine, Research & Experimental

Mechanisms of lymphatic metastasis

Sinem Karaman et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Gastroenterology & Hepatology

Clinical significance of lymph node metastasis in gastric cancer

Jing-Yu Deng et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Article Biochemistry & Molecular Biology

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Hector Peinado et al.

NATURE MEDICINE (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.