Exosome-Based Nanoplatforms: The Emerging Tools for Breast Cancer Therapy

Article Biochemistry & Molecular Biology

Mesenchymal stem cell-derived exosome mir-342-3p inhibits metastasis and chemo-resistance of breast cancer through regulating ID4

Shuyao Yu et al.

Summary: This study reveals that miR-342-3p acts as a potential tumor suppressor by inhibiting metastasis and chemo-resistance of breast cancer cells through targeting ID4.

GENES & GENOMICS (2022)

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Article Nanoscience & Nanotechnology

Construction of an exosome-functionalized graphene oxide based composite bionic smart drug delivery system and its anticancer activity

Qi Chen et al.

Summary: The study leveraged the targeting property of breast cancer tumor cell exosomes to enhance the targeting ability of GO-CO-gamma-PGA, ultimately developing a newly synthesized bionic drug delivery carrier with good drug slow release function and enhanced pro-apoptotic ability for potential application in breast cancer treatment.

NANOTECHNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Exosomes: Cell-Derived Nanoplatforms for the Delivery of Cancer Therapeutics

Hyosuk Kim et al.

Summary: Exosomes are nanovesicles secreted by cells that can mediate intercellular communication and serve as promising drug delivery vehicles due to their stability, biocompatibility, and targeting abilities. They can carry therapeutic signaling molecules from specific cell types, impacting cancer treatment significantly.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, Research & Experimental

PGRN(-/-) TAMs-derived exosomes inhibit breast cancer cell invasion and migration and its mechanism exploration

Shujun Yue et al.

Summary: The study revealed that PGRN(-/-) TAMs inhibit invasion, migration and EMT of breast cancer cells through their exosomes, with miR-5100 identified as a key factor that may regulate this process by modulating CXCL12 expression.

LIFE SCIENCES (2021)

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Article Engineering, Biomedical

Mechanobiological conditioning of mesenchymal stem cells for enhanced vascular regeneration

Jason Lee et al.

Summary: Human mesenchymal stem cells can be conditioned mechanically and pharmacologically to enhance vascular regeneration in vivo. This conditioning increases the activation of signaling pathways and ultimately improves the regenerative properties of the stem cells, providing a potential treatment option for cardiovascular conditions like myocardial infarction.

NATURE BIOMEDICAL ENGINEERING (2021)

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Review Oncology

Exosome-based liquid biopsies in cancer: opportunities and challenges

W. Yu et al.

Summary: Liquid biopsy in cancer research has seen significant progress, with efforts focused on utilizing circulating tumor cells, circulating tumor DNA, and extracellular vesicles like exosomes. Exosomes, as part of the intercellular communication system, carry tumor-derived materials and can serve as stable biomarkers for early detection and monitoring of cancer.

ANNALS OF ONCOLOGY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Cell Biology

The exosomes derived from CAR-T cell efficiently target mesothelin and reduce triple-negative breast cancer growth

Pengxiang Yang et al.

Summary: Exosomes derived from CAR-T cells targeting MSLN showed potential in inhibiting the growth of MSLN-positive triple-negative breast cancer cells, with characteristics similar to parental T cells. The expression of effector molecules may contribute to tumor killing, and in vivo studies demonstrated a highly effective tumor inhibition rate with no obvious side effects. The use of CAR-T cell exosomes has promising therapeutic potential against MSLN-expressing TNBC.

CELLULAR IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

Evaluating the influence of Human Umbilical Cord Mesenchymal Stem Cells-derived exosomes loaded with miR-3182 on metastatic performance of Triple Negative Breast Cancer cells

Yalda Khazaei-Poul et al.

Summary: The study demonstrated that exosomal delivery of miR-3182 can significantly inhibit the proliferation and migration of TNBC cells, while inducing apoptosis. This suggests that exosomes containing miR-3182 could be a promising therapeutic approach in the treatment of TNBC.

LIFE SCIENCES (2021)

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Article Medicine, Research & Experimental

Transfer of miRNA in tumor-derived exosomes suppresses breast tumor cell invasion and migration by inducing M1 polarization in macrophages

Maryam Moradi-Chaleshtori et al.

Summary: The study demonstrated that repolarization of M2 macrophages to M1 phenotype using tumor-derived exosomes loaded with miR-130 led to a reduction in migration and invasion abilities of breast cancer cells. The findings suggest a therapeutic potential in targeting tumor invasion and metastasis in breast cancer through this approach.

LIFE SCIENCES (2021)

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Article Medicine, Research & Experimental

Exosomes derived from miR-34a-overexpressing mesenchymal stem cells inhibit in vitro tumor growth: A new approach for drug delivery

Faezeh Vakhshiteh et al.

Summary: The study demonstrated the potential of genetically modified DPSCs to secrete exosomes enriched with therapeutic miRNAs as a tool for gene delivery. However, optimizing gene-loading approaches is necessary before exosomes can be used as carriers of therapeutic miRNAs.

LIFE SCIENCES (2021)

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Review Immunology

Single-Cell Profiling to Explore Immunological Heterogeneity of Tumor Microenvironment in Breast Cancer

Xiao Yuan et al.

Summary: Immune infiltrates in the tumor microenvironment of breast cancer have a critical role in tumorigenesis, progression, invasion, and therapy resistance, but intratumoral heterogeneity is a major obstacle in understanding and treating breast cancer. Recent advances in single-cell technologies have enabled detailed characterization of intratumoral immune cells, providing insights into the diverse phenotypical and functional aspects of tumor-infiltrating immune cells.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Radiolabeled HER2-directed exosomes exhibit improved cell targeting and specificity

Mahlegha Ghavami et al.

Summary: In this study, a reliable strategy for generating and characterizing targeted radiolabeled exosomes for the quantitative detection of HER2-positive cells was established. The results showed that [In-111]In-oxine-T-exos could potentially be used as an effective imaging tool for HER2 expression.

NANOMEDICINE (2021)

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Review Pharmacology & Pharmacy

The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics

Mingchen Xiong et al.

Summary: Exposure to the external environment can cause skin instability and dysfunction, leading to a variety of skin issues. Exosomes, nanoscale vesicles carrying biomolecules, play a crucial role in shaping physiological and pathological development of the skin, with exogenous exosomes such as stem cell exosomes offering novel treatment options for repairing and rejuvenating skin tissue.

PHARMACOLOGICAL RESEARCH (2021)

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Article Nanoscience & Nanotechnology

Safe and Targeted Sonodynamic Cancer Therapy Using Biocompatible Exosome-Based Nanosonosensitizers

Thuy Giang Nguyen Cao et al.

Summary: Utilizing exosomes as nanocarriers, this study effectively delivered the sonosensitizer ICG to tumor tissues, with surface modification using the cancer-targeting ligand FA to enhance ROS production in breast cancer cells and inhibit tumor growth. The active cancer-targeted FA-ExoICG showed superior tumor accumulation, pharmacokinetic properties, and sonotoxicity against cancer cells compared to ExoICG and free ICG, demonstrating its potential as an effective nanosonosensitizer for safe and targeted cancer treatment.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

Engineered exosome-like nanovesicles suppress tumor growth by reprogramming tumor microenvironment and promoting tumor ferroptosis

Shichuan Hu et al.

Summary: In this study, fibroblast activation protein-alpha (FAP) gene-engineered tumor cell-derived exosome-like vesicle vaccines (eNVs-FAP) were developed as a candidate tumor vaccine targeting both the tumor parenchyma and the stroma. The eNVs-FAP vaccine showed excellent antitumor effects by inducing strong and specific CTL immune responses against tumor cells and FAP +CAFs, and reprogramming the immunosuppressive TME in various cancer models. The mechanistic analysis revealed that eNVs-FAP promoted DC maturation, increased effector T cell infiltration, and reduced immunosuppressive cell populations in the TME, leading to enhanced tumor cell ferroptosis.

ACTA BIOMATERIALIA (2021)

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Article Engineering, Biomedical

Targeted cell therapy for partial-thickness cartilage defects using membrane modified mesenchymal stem cells by transglutaminase 2

Hui Li et al.

Summary: The study demonstrated that modifying a functional polypeptide on the MSC plasma membrane improved the therapeutic efficacy of MSCs in repairing injured articular chondrocytes, showing effectiveness in both in vitro and rabbit models, providing a new cellular therapy approach for articular cartilage defects and other joint diseases.

BIOMATERIALS (2021)

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Article Cell & Tissue Engineering

Adipose-derived mesenchymal stromal cell-derived exosomes promote tendon healing by activating both SMAD1/5/9 and SMAD2/3

Hengchen Liu et al.

Summary: The study demonstrated that ADSC-Exos promoted the proliferation, migration, and tenogenic differentiation of TSCs, possibly through the activation of the SMAD signaling pathways. Additionally, ADSC-Exos inhibited early inflammatory reactions and promoted tendon healing in vivo.

STEM CELL RESEARCH & THERAPY (2021)

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Article Biotechnology & Applied Microbiology

Canine Natural Killer Cell-Derived Exosomes Exhibit Antitumor Activity in a Mouse Model of Canine Mammary Tumor

Jienny Lee et al.

Summary: Canine NK cell-derived exosomes express specific markers and have potential antitumor effects against solid tumors, including mammary carcinoma, by reducing tumor size and impacting tumor progression and recurrence-related markers.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Biotechnology & Applied Microbiology

Exosomes of Mesenchymal Stem Cells as a Proper Vehicle for Transfecting miR-145 into the Breast Cancer Cell Line and Its Effect on Metastasis

Mohsen Sheykhhasan et al.

Summary: This study investigated the role of exosomes derived from adipose tissue-derived mesenchymal stem cells in transfecting miR-145 into breast cancer cells to inhibit their proliferation and metastasis. The results showed that exosome-mediated delivery of miR-145 improved its anticancer properties, suggesting a potential novel therapeutic strategy for breast cancer in the future.

BIOMED RESEARCH INTERNATIONAL (2021)

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Review Biotechnology & Applied Microbiology

Artificial exosomes for translational nanomedicine

Yong-Jiang Li et al.

Summary: Artificial exosomes, produced through nanobiotechnology, have emerged as effective drug delivery carriers and include various types such as nanovesicles, exosome-mimetic, and hybrid exosomes. These artificial exosomes offer solutions to overcome limitations of natural exosomes and are considered powerful alternatives for drug delivery.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Cell & Tissue Engineering

The Application Potential and Advance of Mesenchymal Stem Cell-Derived Exosomes in Myocardial Infarction

Xianyun Wang et al.

Summary: MSC-derived exosomes show therapeutic potential in treating MI and HF by carrying noncoding RNAs and proteins to promote heart function repair. However, optimization of exosomes through various engineering methods is necessary to achieve desired therapeutic effects.

STEM CELLS INTERNATIONAL (2021)

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Review Medicine, Research & Experimental

Engineering exosomes for targeted drug delivery

Yujie Liang et al.

Summary: Exosomes can be engineered through genetic and chemical methods for targeted drug delivery, increasing the local concentration of therapeutics and minimizing side effects.

THERANOSTICS (2021)

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Article Cell & Tissue Engineering

Delivery of miR-381-3p Mimic by Mesenchymal Stem Cell-Derived Exosomes Inhibits Triple Negative Breast Cancer Aggressiveness; an In Vitro Study

Samaneh Shojaei et al.

Summary: This study demonstrated that ADMSC-exosomes efficiently delivered miR-381 mimic to MDA-MB-231 cells, leading to significant inhibition of proliferation, migration, and invasion capabilities of triple-negative breast cancer cells, while promoting apoptosis. This suggests that ADMSC-exosomes have the potential to be effective nanocarriers for RNA-based therapies.

STEM CELL REVIEWS AND REPORTS (2021)

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Article Oncology

In vitro and in vivo evaluation of anti-tumoral effect of M1 phenotype induction in macrophages by miR-130 and miR-33 containing exosomes

Maryam Moradi-Chaleshtori et al.

Summary: Studies have shown that overexpression of miR-130 and miR-33 in exosomes can alter macrophage polarization state and reduce tumor progression. This strategy may have potential therapeutic value for tumor interventions.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

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Article Biotechnology & Applied Microbiology

Genetically Engineered Cell-Derived Nanoparticles for Targeted Breast Cancer Immunotherapy

Xiaojing Shi et al.

MOLECULAR THERAPY (2020)

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Article Chemistry, Multidisciplinary

Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis

Liuwan Zhao et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Oncology

Overcoming Endocrine Resistance in Breast Cancer

Ariella B. Hanker et al.

CANCER CELL (2020)

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Review Oncology

Engineering CAR-T Cells for Next-Generation Cancer Therapy

Mihe Hong et al.

CANCER CELL (2020)

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Article Biochemistry & Molecular Biology

Hyaluronan decoration of milk exosomes directs tumor -specific delivery of doxorubicin

Dan Li et al.

CARBOHYDRATE RESEARCH (2020)

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Article Cell & Tissue Engineering

Photoaging Skin Therapy with PRP and ADSC: A Comparative Study

Luiz Charles-de-Sa et al.

STEM CELLS INTERNATIONAL (2020)

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Article Engineering, Biomedical

An exosome-like programmable-bioactivating paclitaxel prodrug nanoplatform for enhanced breast cancer metastasis inhibition

Kaiyuan Wang et al.

BIOMATERIALS (2020)

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Article Biotechnology & Applied Microbiology

Tumor Exosome Mimicking Nanoparticles for Tumor Combinatorial Chemo-Photothermal Therapy

Ran Tian et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Review Cell Biology

Exosomes and breast cancer drug resistance

Xingli Dong et al.

CELL DEATH & DISEASE (2020)

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Article Oncology

siMTA1-Loaded Exosomes Enhanced Chemotherapeutic Effect of Gemcitabine in Luminal-b Type Breast Cancer by Inhibition of EMT/HIF-α and Autophagy Pathways

Pengping Li et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Cell & Tissue Engineering

Delivery of LNA-antimiR-142-3p by Mesenchymal Stem Cells-Derived Exosomes to Breast Cancer Stem Cells Reduces Tumorigenicity

Zahra Naseri et al.

STEM CELL REVIEWS AND REPORTS (2020)

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Article Chemistry, Multidisciplinary

Engineering macrophage-derived exosomes for targeted chemotherapy of triple-negative breast cancer

Sha Li et al.

NANOSCALE (2020)

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Review Biochemistry & Molecular Biology

Exosomes: key players in cancer and potential therapeutic strategy

Jie Dai et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Biochemistry & Molecular Biology

Engineered Exosomes for Targeted Transfer of siRNA to HER2 Positive Breast Cancer Cells

Shabanali Khodashenas Limoni et al.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2019)

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Article Oncology

Prodrug suicide gene therapy for cancer targeted intracellular by mesenchymal stem cell exosomes

Ursula Altanerova et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

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Review Biochemistry & Molecular Biology

Effects of exosomes on pre-metastatic niche formation in tumors

Yaxin Guo et al.

MOLECULAR CANCER (2019)

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Article Engineering, Biomedical

Macrophage-derived exosome-mimetic hybrid vesicles for tumor targeted drug delivery

Sagar Rayamajhi et al.

ACTA BIOMATERIALIA (2019)

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Article Pharmacology & Pharmacy

Development of a nanoamorphous exosomal delivery system as an effective biological platform for improved encapsulation of hydrophobic drugs

Phuong H. L. Tran et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Review Immunology

Immunomodulation by Mesenchymal Stem Cells (MSCs): Mechanisms of Action of Living, Apoptotic, and Dead MSCs

Andreas Robert Rudolf Weiss et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Oncology

Taxol-Loaded MSC-Derived Exosomes Provide a Therapeutic Vehicle to Target Metastatic Breast Cancer and Other Carcinoma Cells

Catharina Melzer et al.

CANCERS (2019)

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Article Biotechnology & Applied Microbiology

Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy

Chunai Gong et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

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Article Oncology

Targeted exosome-encapsulated erastin induced ferroptosis in triple negative breast cancer cells

Mengyu Yu et al.

CANCER SCIENCE (2019)

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Article Oncology

Exosomes Derived From MicroRNA-148b-3p-Overexpressing Human Umbilical Cord Mesenchymal Stem Cells Restrain Breast Cancer Progression

Lei Yuan et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Medicine, Research & Experimental

Tumor-derived nanovesicles promote lung distribution of the therapeutic nanovector through repression of Kupffer cell-mediated phagocytosis

Xiaolan Qiu et al.

THERANOSTICS (2019)

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Article Biochemistry & Molecular Biology

Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379

K. P. O'Brien et al.

ONCOGENE (2018)

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Article Multidisciplinary Sciences

Exosome-mediated breast cancer chemoresistance via miR-155 transfer

Juliana Carvalho Santos et al.

SCIENTIFIC REPORTS (2018)

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Article Biotechnology & Applied Microbiology

Targeted cancer therapy using engineered exosome as a natura drug delivery vehicle

Hosna Gomari et al.

ONCOTARGETS AND THERAPY (2018)

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Article Medicine, Research & Experimental

Blood exosomes regulate the tissue distribution of grapefruit-derived nanovector via CD36 and IGFR1 pathways

Qi-long Wang et al.

THERANOSTICS (2018)

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Article Biotechnology & Applied Microbiology

Novel alternatives to extracellular vesicle-based immunotherapy - exosome mimetics derived from natural killer cells

Liya Zhu et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

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Article Pharmacology & Pharmacy

A New Approach for Loading Anticancer Drugs Into Mesenchymal Stem Cell-Derived Exosome Mimetics for Cancer Therapy

Senthilkumar Kalimuthu et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Immunology

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING- Dependent Pathway and Reinforce Antitumor Immunity

Yuichi Kitai et al.

JOURNAL OF IMMUNOLOGY (2017)

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Article Chemistry, Multidisciplinary

Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer

Yu Cao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

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Editorial Material Immunology

Novel T-cell-based vaccines via arming polyclonal CD4+ T cells with antigen-specific exosomes

Aizhang Xu et al.

IMMUNOTHERAPY (2016)

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Article Biotechnology & Applied Microbiology

Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models

Mohamad Hadla et al.

NANOMEDICINE (2016)

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Review Immunology

Natural Killer Cell Memory

Timothy E. O'Sullivan et al.

IMMUNITY (2015)

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Article Oncology

Increased anti-tumour activity by exosomes derived from doxorubicin-treated tumour cells via heat stress

Yunshan Yang et al.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2015)

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Article Immunology

Dendritic cell-derived exosomes may be a tool for cancer immunotherapy by converting tumor cells into immunogenic targets

Graziela Gorete Romagnoli et al.

FRONTIERS IN IMMUNOLOGY (2015)

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Article Engineering, Biomedical

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

Yanhua Tian et al.

BIOMATERIALS (2014)

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Article Biotechnology & Applied Microbiology

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

Shin-ichiro Ohno et al.

MOLECULAR THERAPY (2013)

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Exosome-Based Nanoplatforms: The Emerging Tools for Breast Cancer Therapy

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