4.6 Article

Transcriptomic Portraits and Molecular Pathway Activation Features of Adult Spinal Intramedullary Astrocytomas

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Prognostic Factors Independently Associated With Improved Progression-Free Survival After Surgical Resection in Patients With Spinal Cord Astrocytomas: An Institutional Case Series

Ahmed Helal et al.

Summary: In patients with spinal astrocytomas, gross total resection, adjuvant therapy, and low Ki-67 index are independently associated with improved progression-free survival (PFS).

OPERATIVE NEUROSURGERY (2022)

Review Clinical Neurology

H3K27M-mutant glioma in thoracic spinal cord and conus medullaris with pilocytic astrocytoma morphology: case report and review of the literature

Alexis Palpan Flores et al.

Summary: H3K27M-mutant spinal cord glioma, although rare with a variety of histological presentations, can be very aggressive even with features of pilocytic astrocytoma. Despite treatment with surgery and adjuvant chemoradiotherapy, the patient's condition worsened and he eventually developed paraplegia, indicating the poor prognosis associated with this type of tumor.

BRITISH JOURNAL OF NEUROSURGERY (2021)

Article Biochemical Research Methods

CuBlock: a cross-platform normalization method for gene-expression microarrays

Valentin Junet et al.

Summary: The study focused on the normalization of gene-expression microarray data across multiple platforms and time points, developing the CuBlock algorithm which demonstrated superior performance in separating samples from different biological groups. Other popular methods were found to be not applicable in this context.

BIOINFORMATICS (2021)

Article Genetics & Heredity

Algorithmic Annotation of Functional Roles for Components of 3,044 Human Molecular Pathways

Maxim Sorokin et al.

Summary: High-throughput molecular and genomic analyses have allowed for the reconstruction of thousands of human molecular pathways, enabling the investigation of pathway activation levels (PALs) using bioinformatic algorithms. Understanding the functional roles of pathway components is crucial for comprehensive analysis of pathway activation profiles. Annotation of functional roles is necessary for the direct calculation of PALs and establishment of large scale profiles of pathway regulation using gene expression data.

FRONTIERS IN GENETICS (2021)

Article Neurosciences

Molecular diagnostics helps to identify distinct subgroups of spinal astrocytomas

Annamaria Biczok et al.

Summary: This study analyzed molecular markers in primary spinal cord astrocytomas and identified distinct tumor subgroups based on molecular alterations. DMG-H3 tend to develop in adolescence with a poor prognosis, while GBM and HAP are common in the elderly with similar dismal outcomes. Certain tumor subgroups are associated with specific gene mutations.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Human blood serum can donor-specifically antagonize effects of EGFR-targeted drugs on squamous carcinoma cell growth

Dmitry Kamashev et al.

Summary: The study found that many patients do not respond to EGFR-targeted therapeutics, requiring personalized diagnostics. Human serum can affect squamous carcinoma cell growth and EGFR drug response, with significant variation in effects observed across different experiments.

HELIYON (2021)

Review Oncology

RNA sequencing for research and diagnostics in clinical oncology

Anton Buzdin et al.

SEMINARS IN CANCER BIOLOGY (2020)

Article Genetics & Heredity

Cancer gene expression profiles associated with clinical outcomes to chemotherapy treatments

Nicolas Borisov et al.

BMC MEDICAL GENOMICS (2020)

Article Multidisciplinary Sciences

How to do quantile normalization correctly for gene expression data analyses

Yaxing Zhao et al.

SCIENTIFIC REPORTS (2020)

Article Biochemical Research Methods

Shambhala: a platform-agnostic data harmonizer for gene expression data

Nicolas Borisov et al.

BMC BIOINFORMATICS (2019)

Article Biochemistry & Molecular Biology

Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial

Jordi Rodon et al.

NATURE MEDICINE (2019)

Article Multidisciplinary Sciences

Atlas of RNA sequencing profiles for normal human tissues

Maria Suntsova et al.

SCIENTIFIC DATA (2019)

Article Multidisciplinary Sciences

Genomic Landscape of Intramedullary Spinal Cord Gliomas

Ming Zhang et al.

SCIENTIFIC REPORTS (2019)

Article Multidisciplinary Sciences

In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development

Ivan V. Ozerov et al.

NATURE COMMUNICATIONS (2016)

Article Oncology

Periostin is a new potential prognostic biomarker for glioma

Buxian Tian et al.

TUMOR BIOLOGY (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Article Oncology

Perspectives on the immunologic microenvironment of astrocytomas

Iman Hewedi et al.

Cancer Management and Research (2013)

Article Oncology

Fos-related antigen 1 (Fra-1) pairing with and transactivation of JunB in GBM cells

Waldemar Debinski et al.

CANCER BIOLOGY & THERAPY (2011)

Article Oncology

BRAF-KIAA1549 Fusion Predicts Better Clinical Outcome in Pediatric Low-Grade Astrocytoma

Cynthia Hawkins et al.

CLINICAL CANCER RESEARCH (2011)

Article Oncology

Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study

Michael T. Milano et al.

JOURNAL OF NEURO-ONCOLOGY (2010)

Article Biochemical Research Methods

Merging two gene-expression studies via cross-platform normalization

Andrey A. Shabalin et al.

BIOINFORMATICS (2008)

Article Oncology

Successful antiangiogenic therapy for neuroblastoma with thalidomide

Benjamin Gesundheit et al.

JOURNAL OF CLINICAL ONCOLOGY (2007)

Article Behavioral Sciences

Controlling the false discovery rate in behavior genetics research

Y Benjamini et al.

BEHAVIOURAL BRAIN RESEARCH (2001)