期刊
FRONTIERS IN ONCOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.870983
关键词
miR-608; cancer; biomarker; molecular mechanism; tumor suppressor
类别
资金
- National Key Research and Development Program of China [2016YFC1101404/3]
- Independent Project Fund of the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases
miR-608 is decreased in cancer, especially in solid tumors, and acts as a tumor suppressor. It inhibits transmembrane proteins and multiple signaling pathways, participating in various biological processes in cancer cells, such as proliferation and migration.
In recent years, microRNAs (miRNAs) have attracted much attention because of their prominent role in cancer. An increasing number of studies have shown that miRNAs play an important role in a variety of tumors. miR-608 has been reported to be decreased in cancers, especially in solid tumors. miR-608 is regarded as a tumor suppressor, which has been verified through a large number of experiments both in vivo and in vitro. miR-608 participates in many biological processes, including cell proliferation, invasion, migration, and apoptosis, by inhibiting transmembrane proteins and many signaling pathways. Here, we summarize the expression profile and biological functions and mechanism of miR-608, suggesting that miR-608 is an ideal diagnostic and prognostic biomarker and a treatment target for cancer.
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