SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment

Letter Cell Biology

Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates

Denisa Bojkova et al.

CELL RESEARCH (2022)

添加到收藏夹

News Item Multidisciplinary Sciences

OMICRON MAKES A FEEBLE ATTACK ON THE LUNGS

Max Kozlov

NATURE (2022)

添加到收藏夹

Article Immunology

Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses - are we our own worst enemy?

Lok-Yin Roy Wong et al.

Summary: Human coronaviruses can cause a wide range of diseases, with severe cases characterized by dysregulated host immune responses and active viral interference. The severity of disease is mainly determined by host immune responses and viral interference.

NATURE REVIEWS IMMUNOLOGY (2022)

添加到收藏夹

Article Medicine, General & Internal

Repurposed Antiviral Drugs for Covid-19-Interim WHO Solidarity Trial Results

Summary: The authors of the study reported the interim results of using four repurposed antiviral drugs (remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a) in hospitalized COVID-19 patients. The study showed that these drug regimens had little or no effect on overall mortality, initiation of ventilation, and duration of hospital stay.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Article Infectious Diseases

Efficacy and safety of pegylated interferon-α2b in moderate COVID-19: a phase 3, randomized, comparator-controlled, open-label study

Shashi B. L. Bhushan et al.

Summary: The study showed that PEG IFN-alpha 2b administered with standard of care can improve the clinical status of patients with moderate COVID-19, promote early viral clearance, decrease the duration of supplemental oxygen, and has the potential as a viable treatment option to limit the spread of SARS-CoV-2.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Cell Biology

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

Xin Yin et al.

Summary: Recent studies show that cellular responses to SARS-CoV-2 infection may influence disease severity, with MDA5 and LGP2 primarily regulating IFN induction in lung epithelial cells. Further analysis revealed that viral intermediates specifically activate the IFN response through MDA5-mediated sensing, and transcription factors IRF3, IRF5, and NF-kappa B/p65 play key roles in regulating the IFN response during SARS-CoV-2 infection. These findings provide valuable insights into the molecular mechanisms of innate immune recognition and signaling response to SARS-CoV-2.

CELL REPORTS (2021)

添加到收藏夹

Article Virology

SARS-CoV-2 Triggers an MDA-5-Dependent Interferon Response Which Is Unable To Control Replication in Lung Epithelial Cells

Antoine Rebendenne et al.

Summary: The study found that in lung cells, despite producing high levels of IFNs in response to SARS-CoV-2 infection, the IFN response was unable to control viral replication, contrary to what was observed in intestinal epithelial cells. The ambiguous interplay between viral replication and the timing of IFN responses needs to be further understood for guiding future therapeutic interventions.

JOURNAL OF VIROLOGY (2021)

添加到收藏夹

Article Critical Care Medicine

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial

Phillip D. Monk et al.

Summary: The study evaluated the efficacy and safety of using interferon beta-1a to treat COVID-19, with results showing that patients who received treatment had higher and faster recovery rates, providing potential evidence for further clinical trials.

LANCET RESPIRATORY MEDICINE (2021)

添加到收藏夹

Letter Medicine, General & Internal

Differential roles of RIG-I like receptors in SARS-CoV-2 infection

Duo-Meng Yang et al.

Summary: MDA5 is identified as the primary sensor for SARS-CoV-2, while RIG-I plays an anti-viral role in epithelial cells. Deficiencies in MDA5, RIG-I, or MAVS enhance viral replication.

MILITARY MEDICAL RESEARCH (2021)

添加到收藏夹

Article Immunology

Expression of innate immune response genes in upper airway samples of SARS-CoV-2 infected patients: A preliminary study

Madhu Mohanty et al.

Summary: The study revealed increased expression of TLR2, MDA5, and ACE2 in upper airway cells of SARS-CoV-2 infected patients. Patients with asymptomatic and mild symptoms showed significantly higher levels of MDA5 compared to severe cases. The asymptomatic group also exhibited a significant induction of type 1 interferons compared to symptomatic patients.

INDIAN JOURNAL OF MEDICAL RESEARCH (2021)

添加到收藏夹

Article Medicine, General & Internal

Effect of a genetically engineered interferon-alpha versus traditional interferon-alpha in the treatment of moderate-to-severe COVID-19: a randomised clinical trial

Chuan Li et al.

Summary: There are limited effective therapies available for COVID-19. In a multicenter randomized trial, rSIFN-co therapy combined with baseline antiviral agents showed a faster time to clinical improvement compared to traditional interferon-alpha therapy combined with antiviral agents.

ANNALS OF MEDICINE (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

Ting-Chao Chou

PHARMACOLOGICAL REVIEWS (2006)

添加到收藏夹

SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment

相关参考文献

导出引文

分享论文