4.3 Article

NF-κB-Activated lncRNACASC9 Promotes Bladder Cancer Progression by Regulating the TK1 Expression

期刊

JOURNAL OF ONCOLOGY
卷 2022, 期 -, 页码 -

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HINDAWI LTD
DOI: 10.1155/2022/9905776

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  1. Suqian SciTech Program [K201901]
  2. Natural Science Foundation of the Jiangsu Higher Education Institutions of China [19KJB320008]
  3. Jiangsu Province, Key Research, and Development Program [BE2019637, BE2017635]
  4. High-Level Health Talents Six One Project Top Talents [LGY2019058]
  5. Jiangsu Medical Innovation Team [CXTDA-2017-48]
  6. National Natural Science Foundation of China [81774089]
  7. Xuzhou Science and Technology Program [KC18036]
  8. Xuzhou Medical Outstanding Talents (Xuzhou Health Education Research) [2017] [22]

向作者/读者索取更多资源

This study identifies abnormally expressed lncRNAs in bladder cancer, with a specific focus on the role of CASC9 in promoting bladder cancer cell growth and metastasis through regulation of miR-195-5p. The findings suggest that targeting the CASC9/miR-195-5p/TK1 axis could be a promising therapeutic strategy for bladder cancer treatment.
Long noncoding RNAs (lncRNA) are involved in cancer development, but the roles of most lncRNAs are undocumented. In this study, we identified lncRNAs that were abnormally expressed in bladder cancer. We found that lncRNACASC9 plays an important role in the progression of bladder cancer. CASC9 was highly expressed in bladder cancer cells and tissues, and the prognosis of bladder cancer patients with high expression of CASC9 was poor. The results of colony formation assays, CCK-8 assays, EdU assays, transwell assays, mouse xenograft models, and tail vein injection lung metastasis model showed that CASC9 could promote bladder cancer cells growth and metastasis both in vitro and in vivo. Mechanistically, through FISH experiments, luciferase reporter experiments, and RIP experiments, we proved that CASC9 regulated the expression of TK1 by adsorbing miR-195-5p, thereby exerting an oncogenic effect in bladder cancer. Taken together, our findings support that the CASC9/miR-195-5p/TK1 axis is a critical pathway in the tumorigenesis and progression of bladder cancer, implicating a new therapeutic direction for the treatment of bladder cancer.

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