Changes in target ability of nanoparticles due to protein corona composition and disease state

Many studies have shown the influence of protein corona (PC) on the active targeting capability of ligand-modified nanoparticles; however, the influence of clinical status on PC composition and targeting capacity is rarely discussed. In this study, when transferrin-modified PEGylated polystyrene nanoparticles (Tf-PNs) is intravenously injected into mice with non-small cell lung cancer (NSCLC) comorbid with type 2 diabetes mellitus (T2DM), more Tf-PNs accumulated in the tumor tissue than in those of NSCLC model mice. This indicated that PC derived from different states of disease changed the active targeting ability of Tf-PNs. To explain the occurrence of this phenomenon, our analysis of PC from different disease states revealed that Tf (transferrin) modification had no significant effect on the formation of PC, and that the PC from the NSCLC comorbid with T2DM model contained more proteins like fibrin and clusterin. This work demonstrates the impacts of comorbidity, such as with T2DM, on the active targeting capability of ligand-modified nanoparticles, and the results promote the application of nanoparticles for precision medicine. (C) 2022 Shenyang Pharmaceutical University. Published by Elsevier B.V.

Automated summary

This study reveals the impact of clinical status, specifically comorbidities like type 2 diabetes mellitus (T2DM), on the protein corona (PC) composition and active targeting capability of ligand-modified nanoparticles. The results demonstrate that the presence of T2DM in non-small cell lung cancer (NSCLC) mice alters the active targeting ability of transferrin-modified PEGylated polystyrene nanoparticles (Tf-PNs), leading to increased accumulation of Tf-PNs in tumor tissues. Analysis of the PC from different disease states suggests that Tf modification does not significantly affect PC formation, while the PC composition in the NSCLC comorbid with T2DM model contains more proteins like fibrin and clusterin.