4.6 Article

COX-2 Deficiency Promotes White Adipogenesis via PGE2-Mediated Paracrine Mechanism and Exacerbates Diet-Induced Obesity

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Summary: The intermittent fasting (IF) diet has been found to have significant benefits for diabetes prevention, but the specific mechanisms underlying its effects are not well understood. This study shows that COX-2 expression is suppressed in the white adipose tissue (WAT) of obese humans and is upregulated in the WAT of obese mice when subjected to IF. Depletion of COX-2 in adipocytes leads to a decrease in the fractions of Tregs and a decrease in the frequency of macrophages in WAT, along with an increase in the abundance of gamma delta T cells. Adipocyte-derived PGE2 promotes Treg proliferation and is essential for the immune and metabolic benefits of IF.

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