期刊
CELLS
卷 11, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/cells11060939
关键词
tissue-engineered vascular grafts; regeneration; late failure; immune response; atherogenesis; intimal hyperplasia
类别
资金
- [RC #819-2017]
- [277877758172]
This study aims to analyze and evaluate the bio-molecular interactions and hemodynamic phenomena related to the failure of tissue-engineered vascular grafts (TEVGs) during the regeneration process, in order to optimize their design.
Tissue-engineered vascular grafts (TEVGs) are a promising alternative to treat vascular disease under complex hemodynamic conditions. However, despite efforts from the tissue engineering and regenerative medicine fields, the interactions between the material and the biological and hemodynamic environment are still to be understood, and optimization of the rational design of vascular grafts is an open challenge. This is of special importance as TEVGs not only have to overcome the surgical requirements upon implantation, they also need to withhold the inflammatory response and sustain remodeling of the tissue. This work aims to analyze and evaluate the bio-molecular interactions and hemodynamic phenomena between blood components, cells and materials that have been reported to be related to the failure of the TEVGs during the regeneration process once the initial stages of preimplantation have been resolved, in order to tailor and refine the needed criteria for the optimal design of TEVGs.
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