期刊
CELLS
卷 11, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/cells11060940
关键词
non-coding RNAs; miRNAs; iPSCs; neuronal reprogramming; cardiac reprogramming
类别
资金
- H2020-FETOPEN-2018-2019-2020-01 ENLIGHT [964497]
- COINOR grant STAR Linea1-2018, DOPAncODE [18-CSP-UNINA-042]
- PRIN-2017 (2017CH4RNP) grant
Cell reprogramming is a groundbreaking technology that can generate various cell types by converting somatic cells and modulating the expression of key transcription factors. The role of microRNAs in the reprogramming processes of generating pluripotent stem cells, neurons, and cardiomyocytes is significant and has potential biomedical applications.
Cell reprogramming is a groundbreaking technology that, in few decades, generated a new paradigm in biomedical science. To date we can use cell reprogramming to potentially generate every cell type by converting somatic cells and suitably modulating the expression of key transcription factors. This approach can be used to convert skin fibroblasts into pluripotent stem cells as well as into a variety of differentiated and medically relevant cell types, including cardiomyocytes and neural cells. The molecular mechanisms underlying such striking cell phenotypes are still largely unknown, but in the last decade it has been proven that cell reprogramming approaches are significantly influenced by non-coding RNAs. Specifically, this review will focus on the role of microRNAs in the reprogramming processes that lead to the generation of pluripotent stem cells, neurons, and cardiomyocytes. As highlighted here, non-coding RNA-forced expression can be sufficient to support some cell reprogramming processes, and, therefore, we will also discuss how these molecular determinants could be used in the future for biomedical purposes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据