4.6 Article

(±)-Catechin-A Mass-Spectrometry-Based Exploration Coordination Complex Formation with FeII and FeIII

期刊

CELLS
卷 11, 期 6, 页码 -

出版社

MDPI
DOI: 10.3390/cells11060958

关键词

Alzheimer's disease; antioxidant; brine shrimp; Fenton reaction; flavonoid; hydroxyl radical; iron chelate; neurodegeneration; Parkinson's disease; reactive oxygen species

资金

  1. Austrian Science Fund (FWF) [P 24630-B21]

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Catechin can form coordination complexes with Fe ions, showing antioxidant properties and potential for the treatment of degenerative diseases such as Alzheimer's and Parkinson's.
Catechin is an extensively investigated plant flavan-3-ol with a beneficial impact on human health that is often associated with antioxidant activities and iron coordination complex formation. The aim of this study was to explore these properties with Fe-II and Fe-III using a combination of nanoelectrospray-mass spectrometry, differential pulse voltammetry, site-specific deoxyribose degradation assay, Fe-II autoxidation assay, and brine shrimp mortality assay. Catechin primarily favored coordination complex formation with Fe ions of the stoichiometry catechin:Fe in the ratio of 1:1 or 2:1. In the detected Fe-catechin coordination complexes, Fe-II prevailed. Differential pulse voltammetry, the site-specific deoxyribose degradation, and Fe-II autoxidation assays proved that coordination complex formation affected catechin's antioxidant effects. In situ formed Fe-catechin coordination complexes showed no toxic activities in the brine shrimp mortality assay. In summary, catechin has properties for the possible treatment of pathological processes associated with ageing and degeneration, such as Alzheimer's and Parkinson's diseases.

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