4.6 Article

IFN-γ Induces PD-L1 Expression in Primed Human Basophils

期刊

CELLS
卷 11, 期 5, 页码 -

出版社

MDPI
DOI: 10.3390/cells11050801

关键词

human basophils; PD-L1; IFN-gamma; IL-3; IL-4; IL-13; IFNGR2

资金

  1. Agence Nationale de la Recherche, France [ANR-19-CE17-0021]

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This study identifies IFN-gamma as one of the factors that induce PD-L1 expression in human basophils and demonstrates the importance of IL-3 priming in IFN-gamma-induced PD-L1 expression.
Programmed death-ligand 1 (PD-L1) plays a key role in maintaining immune tolerance and also in immune evasion of cancers and pathogens. Though the identity of stimuli that induce PD-L1 in various human innate cells and their function are relatively well studied, data on the basophils remain scarce. In this study, we have identified one of the factors, such as IFN-gamma, that induces PD-L1 expression in human basophils. Interestingly, we found that basophil priming by IL-3 is indispensable for IFN-gamma -induced PD-L1 expression in human basophils. However, priming by other cytokines including granulocyte-macrophage colony-stimulating factor (GM-CSF) and thymic stromal lymphopoietin (TSLP) was dispensable. Analyses of a published microarray data set on IL-3-treated basophils indicated that IL-3 enhances IFNGR2, one of the chains of the IFNGR heterodimer complex, and CD274, thus providing a mechanistic insight into the role of IL-3 priming in IFN-gamma -induced PD-L1 expression in human basophils.

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