Impact of Glucocorticoid Use in Oncology in the Immunotherapy Era

Thanks to their anti-inflammatory, anti-oedema, and anti-allergy properties, glucocorticoids are among the most widely prescribed drugs in patients with cancer. The indications for glucocorticoid use are very wide and varied in the context of cancer and include the symptomatic management of cancer-related symptoms (compression, pain, oedema, altered general state) but also prevention or treatment of common side effects of anti-cancer therapies (nausea, allergies, etc.) or immune-related adverse events (irAE). In this review, we first give an overview of the different clinical situations where glucocorticoids are used in oncology. Next, we describe the current state of knowledge regarding the effects of these molecules on immune response, in particular anti-tumour response, and we summarize available data evaluating how these effects may interfere with the efficacy of immunotherapy using immune checkpoint inhibitors.

Automated summary

Glucocorticoids are widely prescribed drugs in cancer patients due to their anti-inflammatory, anti-oedema, and anti-allergy properties. They are used in various clinical situations in oncology, including managing cancer-related symptoms and preventing or treating side effects or immune-related adverse events of anti-cancer therapies. Moreover, glucocorticoids have been found to affect immune response and tumor efficacy.