期刊
CELLS
卷 11, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/cells11061054
关键词
NAADP; Ca2+ signaling; Ca2+ microdomains; dual NADPH oxidase (DUOX); hematological and neurological expressed 1-like protein (HN1L); Jupiter microtubule-associated homolog 2 (JPT2); ryanodine receptor (RYR); two-pore channel (TPC)
类别
资金
- Deutsche Forschungsgemeinschaft (DFG) [335447717, SFB1328]
- Joachim-Herz-Stiftung (Hamburg)
- NCL-Stiftung Hamburg
- Hamburg Ministry of Science, Research and Equality [LFF-FV75/0070-134]
- University Medical Center Hamburg-Eppendorf
- Infectophysics Consortium
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a crucial Ca2+ mobilizing second messenger involved in the initiation of Ca2+ signaling. Recent studies have revealed novel molecular mechanisms of its formation and mode of action.
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a universal Ca2+ mobilizing second messenger essential for initiation of Ca2+ signaling. Recently, novel molecular mechanisms of both its rapid formation upon receptor stimulation and its mode of action were discovered. Dual NADPH oxidase 2 (DUOX2) and hematological and neurological expressed 1-like protein (HN1L)/Jupiter microtubule-associated homolog 2 (JPT2) were discovered as NAADP-forming enzyme and NAADP receptor/binding protein-the new kids on the block. These novel aspects are reviewed and integrated into the previous view of NAADP signaling.
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