相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy
Devesh Tewari et al.
SEMINARS IN CANCER BIOLOGY (2022)
Can Next-Generation PI3K Inhibitors Unlock the Full Potential of the Class in Patients With B-Cell Lymphoma?
Tycel J. Phillips et al.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2021)
3D culture conditions support Kaposi's sarcoma herpesvirus (KSHV) maintenance and viral spread in endothelial cells
Tatyana Dubich et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2021)
Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin
Tobias Wijshake et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
The Role of mTOR Signaling as a Therapeutic Target in Cancer
Nadezhda V. Popova et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Autophagy is a major metabolic regulator involved in cancer therapy resistance
Laura Poillet-Perez et al.
CELL REPORTS (2021)
mTOR at the nexus of nutrition, growth, ageing and disease
Grace Y. Liu et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
Cracking the context-specific PI3K signaling code
Ralitsa R. Madsen et al.
SCIENCE SIGNALING (2020)
SuperPlots: Communicating reproducibility and variability in cell biology
Samuel J. Lord et al.
JOURNAL OF CELL BIOLOGY (2020)
PI3Kδ Inhibition as a Potential Therapeutic Target in COVID-19
Giuseppe Palma et al.
FRONTIERS IN IMMUNOLOGY (2020)
Targeting PI3K in cancer: mechanisms and advances in clinical trials
Jing Yang et al.
MOLECULAR CANCER (2019)
Stimulation of Hair Growth by Small Molecules that Activate Autophagy
Min Chai et al.
CELL REPORTS (2019)
The Role of PI3K Inhibition in Lymphoid Malignancies
Gottfried von Keudell et al.
CURRENT HEMATOLOGIC MALIGNANCY REPORTS (2019)
SMER28 is a mTOR-independent small molecule enhancer of autophagy that protects mouse bone marrow and liver against radiotherapy
Michael I. Koukourakis et al.
INVESTIGATIONAL NEW DRUGS (2018)
Epstein-Barr Virus Susceptibility in Activated PI3Kδ Syndrome (APDS) Immunodeficiency
Jean-Marie Carpier et al.
FRONTIERS IN IMMUNOLOGY (2018)
Host-pathogen interactions and subversion of autophagy
David G. McEwan
SIGNALLING MECHANISMS IN AUTOPHAGY (2017)
An essential role of PI3K in the control of West Nile virus infection
Leilei Wang et al.
SCIENTIFIC REPORTS (2017)
The PI3K Pathway in Human Disease
David A. Fruman et al.
CELL (2017)
Induction of autophagy by the MG-132 proteasome inhibitor is associated with endoplasmic reticulum stress in MCF-7 cells
Wenhua Bao et al.
MOLECULAR MEDICINE REPORTS (2016)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J. Klionsky et al.
AUTOPHAGY (2016)
Proteasome inhibitor MG132 impairs autophagic flux through compromising formation of autophagosomes in Bombyx cells
Ming -Ming Ji et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)
Idelalisib given front-line for treatment of chronic lymphocytic leukemia causes frequent immune-mediated hepatotoxicity
Benjamin L. Lampson et al.
BLOOD (2016)
Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination
Jason S. L. Yu et al.
DEVELOPMENT (2016)
Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy
Klaus Okkenhaug et al.
CANCER DISCOVERY (2016)
Idelalisib: First-in-Class PI3K Delta Inhibitor for the Treatment of Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, and Follicular Lymphoma
Qingshan Yang et al.
CLINICAL CANCER RESEARCH (2015)
Autophagy Modulates Articular Cartilage Vesicle Formation in Primary Articular Chondrocytes
Ann K. Rosenthal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Regulation of mTORC1 by PI3K signaling
Christian C. Dibble et al.
TRENDS IN CELL BIOLOGY (2015)
AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation
Valentina Cianfanelli et al.
NATURE CELL BIOLOGY (2015)
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting
Lauren M. Thorpe et al.
NATURE REVIEWS CANCER (2015)
Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation
Anika Steffen et al.
JOURNAL OF CELL SCIENCE (2013)
Targeted Radiotherapy of Prostate Cancer with a Gastrin-Releasing Peptide Receptor Antagonist Is Effective as Monotherapy and in Combination with Rapamycin
Rebecca A. Dumont et al.
JOURNAL OF NUCLEAR MEDICINE (2013)
Multiple Host Kinases Contribute to Akt Activation during Salmonella Infection
Bernhard Roppenser et al.
PLOS ONE (2013)
mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin
Seong A. Kang et al.
SCIENCE (2013)
Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors
Anne M. Strohecker et al.
CANCER DISCOVERY (2013)
Proteasome Inhibitors: An Expanding Army Attacking a Unique Target
Alexei F. Kisselev et al.
CHEMISTRY & BIOLOGY (2012)
Identification of Components of the Host Type IA Phosphoinositide 3-Kinase Pathway That Promote Internalization of Listeria monocytogenes
Shahanawaz Jiwani et al.
INFECTION AND IMMUNITY (2012)
Functions and Regulation of Circular Dorsal Ruffles
Jing-Ling Hoon et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
Canonical and non-canonical autophagy: variations on a common theme of self-eating?
Patrice Codogno et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
Brian J. Lannutti et al.
BLOOD (2011)
A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway
Yuan Tian et al.
FASEB JOURNAL (2011)
Autophagy-deficient mice develop multiple liver tumors
Akito Takamura et al.
GENES & DEVELOPMENT (2011)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim et al.
NATURE CELL BIOLOGY (2011)
Rapamycin passes the torch: a new generation of mTOR inhibitors
Don Benjamin et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Activation of Akt by the Bacterial Inositol Phosphatase, SopB, is Wortmannin Insensitive
Kendal G. Cooper et al.
PLOS ONE (2011)
Cyclin D as a therapeutic target in cancer
Elizabeth A. Musgrove et al.
NATURE REVIEWS CANCER (2011)
PI3K/p110δ is a novel therapeutic target in multiple myeloma
Hiroshi Ikeda et al.
BLOOD (2010)
Autophagy Suppresses Tumorigenesis through Elimination of p62
Robin Mathew et al.
CELL (2009)
Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition
Madlaina Breuleux et al.
MOLECULAR CANCER THERAPEUTICS (2009)
Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer
Kwang Woon Kim et al.
AUTOPHAGY (2008)
Does bafilomycin A(1) block the fusion of autophagosomes with lysosomes?
Daniel J. Klionsky et al.
AUTOPHAGY (2008)
Discovery and development of the epothilones - A novel class of antineoplastic drugs
Hans Reichenbach et al.
DRUGS IN R&D (2008)
Phosphoinositide-3 kinase-Akt pathway controls cellular entry of Ebola virus
Mohammad F. Saeed et al.
PLOS PATHOGENS (2008)
Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-met in distinct and common pathways
Tanja Bosse et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition
E. K-H Han et al.
ONCOGENE (2007)
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
Sovan Sarkar et al.
NATURE CHEMICAL BIOLOGY (2007)
The PI3K-Akt pathway promotes microtubule stabilization in migrating fibroblasts
Keisuke Onishi et al.
GENES TO CELLS (2007)
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
Estela Jacinto et al.
CELL (2006)
Bacteria-host-cell interactions at the plasma membrane: Stories on actin cytoskeleton subversion
K Rottner et al.
DEVELOPMENTAL CELL (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)