4.6 Article

Stable Integration of Inducible SPLICS Reporters Enables Spatio-Temporal Analysis of Multiple Organelle Contact Sites upon Modulation of Cholesterol Traffic

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemical Research Methods

Quantification of organelle contact sites by split-GFP-based contact site sensors (SPLICS) in living cells

Tito Cali et al.

Summary: Membrane contact sites between organelles play a crucial role in cellular homeostasis and can be quantified using SPLICS sensors in both fixed and living cells.

NATURE PROTOCOLS (2021)

Article Biology

Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling

Luana Naia et al.

Summary: This study established a large-scale screening platform for mitochondrial-based modulators and identified luteolin as a compound with potential therapeutic validity for various human diseases by increasing mitochondrial activity through enhancing interactions between mitochondria and endoplasmic reticulum. The findings suggest a novel mechanism for luteolin's modulation of mitochondrial function in neuronal models and potential therapeutic applications.

BMC BIOLOGY (2021)

Review Cell Biology

Cholesterol transport between cellular membranes: A balancing act between interconnected lipid fluxes

Elina Ikonen et al.

Summary: This article summarizes the asymmetric distribution of cholesterol in mammalian cells and its co-transport with other lipids, discussing lipid transfer proteins at membrane contacts and membrane transport. It also reviews the physiological evidence related to this process.

DEVELOPMENTAL CELL (2021)

Review Biochemistry & Molecular Biology

Hexokinase 2 in Cancer: A Prima Donna Playing Multiple Characters

Francesco Ciscato et al.

Summary: Hexokinases, particularly Hexokinase 2 (HK2), play a critical role in glucose metabolism and are highly expressed in insulin-sensitive tissues and neoplastic cells. In addition to its enzymatic activity, HK2 can regulate autophagy and cell death, as well as intracellular Ca2+ fluxes, at the mitochondria-associated membranes (MAMs). Targeting HK2 subcellular localization in MAMs may offer a promising anti-tumor strategy by disrupting its functions in metabolic and survival pathways.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

Endoplasmic reticulum-mitochondria coupling increases during doxycycline-induced mitochondrial stress in HeLa cells

Camila Lopez-Crisosto et al.

Summary: Subcellular organelles communicate and coordinate responses, with the physical coupling of the endoplasmic reticulum (ER) and mitochondria playing a key role in boosting mitochondrial metabolic activity. The mitochondrial unfolded protein response (mtUPR) is activated by unfolded proteins, leading to transcriptional responses aimed at restoring protein homeostasis. Increase in mitochondrial-ER coupling during mitochondrial stress can potentiate mitochondrial metabolic activity as a part of protective response.

CELL DEATH & DISEASE (2021)

Review Cell Biology

The functional universe of membrane contact sites

William A. Prinz et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Cell Biology

Mechanisms and regulation of cholesterol homeostasis

Jie Luo et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Multidisciplinary Sciences

Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

Michael N. Trinh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Biochemistry & Molecular Biology

The ER chaperone calnexin controls mitochondrial positioning and respiration

Tomas Gutierrez et al.

SCIENCE SIGNALING (2020)

Review Cell Biology

Cholesterol Handling in Lysosomes and Beyond

Ying Meng et al.

TRENDS IN CELL BIOLOGY (2020)

Review Cell Biology

Active cholesterol 20 years on

Yvonne Lange et al.

TRAFFIC (2020)

Article Multidisciplinary Sciences

An expanded palette of improved SPLICS reporters detects multiple organelle contacts in vitro and in vivo

Francesca Vallese et al.

NATURE COMMUNICATIONS (2020)

Article Cell Biology

Improved Split-GFP Systems for Visualizing Organelle Contact Sites in Yeast and Human Cells

Shinya Tashiro et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Multidisciplinary Sciences

Coming together to define membrane contact sites

Luca Scorrano et al.

NATURE COMMUNICATIONS (2019)

Article Biophysics

Split Green Fluorescent Proteins: Scope, Limitations, and Outlook

Matthew G. Romei et al.

Annual Review of Biophysics (2019)

Review Biochemistry & Molecular Biology

Intracellular second messengers mediate stress inducible hormesis and Programmed Cell Death: A review

David R. Zhou et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2019)

Article Multidisciplinary Sciences

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

D. Hoglinger et al.

NATURE COMMUNICATIONS (2019)

Article Medicine, General & Internal

Variants in Miro1 Cause Alterations of ER-Mitochondria Contact Sites in Fibroblasts from Parkinson's Disease Patients

Clara Berenguer-Escuder et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Article Cell Biology

A novel fluorescent reporter detects plastic remodeling of mitochondria-ER contact sites

Zhaoying Yang et al.

JOURNAL OF CELL SCIENCE (2018)

Article Biochemistry & Molecular Biology

Tau localises within mitochondrial sub-compartments and its caspase cleavage affects ER-mitochondria interactions and cellular Ca2+ handling

Domenico Cieri et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Article Biochemistry & Molecular Biology

TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer

Riccardo Filadi et al.

CURRENT BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Lysosomal acid lipase and lipid metabolism: new mechanisms, new questions, and new therapies

Hanrui Zhang

CURRENT OPINION IN LIPIDOLOGY (2018)

Review Biochemistry & Molecular Biology

Cholesterol transfer at endosomal-organelle membrane contact sites

Neale D. Ridgway et al.

CURRENT OPINION IN LIPIDOLOGY (2018)

Article Biochemistry & Molecular Biology

Ultrastructural localisation of protein interactions using conditionally stable nanobodies

Nicholas Ariotti et al.

PLOS BIOLOGY (2018)

Article Biochemistry & Molecular Biology

SPLICS: a split green fluorescent protein-based contact site sensor for narrow and wide heterotypic organelle juxtaposition

Domenico Cieri et al.

CELL DEATH AND DIFFERENTIATION (2018)

Review Cell Biology

Emerging Roles for the Lysosome in Lipid Metabolism

Ashley M. Thelen et al.

TRENDS IN CELL BIOLOGY (2017)

Review Cell Biology

Structure and function of ER membrane contact sites with other organelles

Melissa J. Phillips et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

FATE1 antagonizes calcium- and drug-induced apoptosis by uncoupling ER and mitochondria

Mabrouka Doghman-Bouguerra et al.

EMBO REPORTS (2016)

Article Biochemistry & Molecular Biology

Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts

Bei-Bei Chu et al.

Review Cell Biology

Membrane lipids: where they are and how they behave

Gerrit van Meer et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)