☆ 4.6 Review

Platelets, a Key Cell in Inflammation and Atherosclerosis Progression

CELLS (2022)

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Differential Effects of Platelet Factor 4 (CXCL4) and Its Non-Allelic Variant (CXCL4L1) on Cultured Human Vascular Smooth Muscle Cells

Dawid M. Kaczor et al.

Summary: Platelet factor 4 (CXCL4) is a chemokine stored in platelets that modulates the function of vascular smooth muscle cells (VSMCs). Variant CXCL4L1, despite minor differences, has distinct effects on VSMCs compared to CXCL4. Both CXCL4 and CXCL4L1 regulate gene expression, but only CXCL4 increases VSMC proliferation and calcification.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Chemistry, Multidisciplinary

Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising Hemostasis

Jianhua Mao et al.

Summary: Conventional antiplatelet agents inhibit both thrombosis and hemostasis, but their increased bleeding risk limits their effectiveness. Blocking outside-in signaling of integrin alpha IIb beta 3 can resolve this issue. The small molecule DCDBS84 disrupts beta 3/Src interaction and inhibits thrombosis without compromising hemostasis.

ADVANCED SCIENCE (2022)

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Review Hematology

Platelet activation and prothrombotic mediators at the nexus of inflammation and atherosclerosis: Potential role of antiplatelet agents

Ronan Lordan et al.

Summary: Platelets play a crucial role in cardiovascular diseases by modulating inflammatory pathways that impact pro-inflammatory and coagulation processes. Current antiplatelet therapies, while effective, come with an increased risk of bleeding, prompting the need for further research into safer alternative treatments.

BLOOD REVIEWS (2021)

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Article Cardiac & Cardiovascular Systems

The chemokine CXCL14 mediates platelet function and migration via direct interaction with CXCR4

Alexander Witte et al.

Summary: This study reveals that CXCL14 is a novel platelet-derived chemokine involved in thrombus formation and platelet migration, with CXCR4 identified as the principal receptor for CXCL14, promoting platelet migration.

CARDIOVASCULAR RESEARCH (2021)

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Review Hematology

Interplay between platelets and coagulation

Yaqiu Sang et al.

Summary: Haemostasis is a regulated physiological process involving interactions between endothelial cells, platelets, von Willebrand factor, and coagulation factors. Platelets and coagulation mutually influence each other to effectively stop bleeding by forming a platelet plug.

BLOOD REVIEWS (2021)

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Review Pharmacology & Pharmacy

Molecular basis and therapeutic implications of CD40/CD40L immune checkpoint

TingTing Tang et al.

Summary: The CD40 receptor and its ligand CD40L play a critical role in immune activation, with various therapeutic agents targeting this interaction showing promising clinical efficacy in treating malignancies and autoimmune diseases. The signaling pathways activated by CD40/CD40L interaction lead to immune cell activation and modulation, making it an attractive target for immunotherapy. Ongoing and completed clinical trials have demonstrated the potential of CD40/CD40L-targeted therapy in activating immune responses and treating diseases.

PHARMACOLOGY & THERAPEUTICS (2021)

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Review Cell Biology

Inflammatory Chemokines in Atherosclerosis

Selin Gencer et al.

Summary: Atherosclerosis is a chronic inflammatory disease of the vessel wall leading to occlusive lesions in large arteries. Chemokines and their receptors play a key role in the development of atherosclerotic lesions by orchestrating immune cell activation and recruitment. Recent research has focused on targeting these chemokines for potential treatment of atherosclerosis.

CELLS (2021)

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Article Cell Biology

Endothelial transmigration of platelets depends on soluble factors released by activated endothelial cells and monocytes

Ricardo Huilcaman et al.

Summary: The study found that platelets have the ability to migrate during atherosclerosis, and factors secreted by monocytes can enhance the migratory and aggregating capabilities of platelets.

PLATELETS (2021)

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Article Cell Biology

Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity

Silvia Oggero et al.

Summary: Extracellular vesicles released by mixed aggregates of monocytes and platelets have pro-inflammatory effects on endothelial cells and atherosclerotic plaques, and modulating platelet activation can alter the composition and actions of these vesicles, potentially providing therapeutic avenues for atherosclerosis treatment. Patients with coronary artery disease requiring intervention show elevated levels of specific EV subsets in plasma.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Endocrinology & Metabolism

Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFR beta and bioenergetic mechanisms

Alexandra A. C. Newman et al.

Summary: The study found that stable atherosclerotic plaques are composed of cells from various origins, including smooth muscle cells, endothelial cells, and macrophages that undergo different transitions to produce myofibroblast-like cells. Additionally, it was shown that myofibroblasts derived from endothelial-to-mesenchymal transition and macrophage-to-mesenchymal transition cannot indefinitely compensate for the loss of smooth muscle cell-derived myofibroblasts. Furthermore, the transitions from smooth muscle cells to myofibroblasts are induced by PDGF and TGF-beta, while endothelial-to-mesenchymal transition is induced by interleukin-1 beta and TGF-beta.

NATURE METABOLISM (2021)

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Article Biochemistry & Molecular Biology

Platelet Activation Is Triggered by Factors Secreted by Senescent Endothelial HMEC-1 Cells In Vitro

Whitney Venturini et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Oncology

Role of platelet biomarkers in inflammatory response

Yufei Chen et al.

BIOMARKER RESEARCH (2020)

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Article Hematology

Conformation-Specific Blockade of αIIbβ3 by a Non-RGD Peptide to Inhibit Platelet Activation without Causing Significant Bleeding and Thrombocytopenia

Chuanbin Shen et al.

THROMBOSIS AND HAEMOSTASIS (2020)

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Review Immunology

Regulation of Innate Immune Responses by Platelets

Lucas Secchim Ribeiro et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Biochemistry & Molecular Biology

Platelet-derived chemokines in inflammation and atherosclerosis

Constantinos Bakogiannis et al.

CYTOKINE (2019)

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Article Cell Biology

Platelet-endothelial cell interactions modulate smooth muscle cell phenotype in an in vitro model of type 2 diabetes mellitus

Min Zeng et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2019)

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Review Biochemistry & Molecular Biology

Oxidative pathways of arachidonic acid as targets for regulation of platelet activation

Andres Trostchansky et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2019)

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Article Medicine, Research & Experimental

Preclinical studies of RUC-4, a novel platelet αIIbβ3 antagonist, in non-human primates and with human platelets

Spandana Vootukuri et al.

JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE (2019)

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Article Hematology

Platelets kill bacteria by bridging innate and adaptive immunity via platelet factor 4 and FcγRIIA

R. Palankar et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2018)

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Review Cardiac & Cardiovascular Systems

Acetylsalicylic acid and clopidogrel hyporesponsiveness following acute coronary syndromes

Udaya S. Tantry et al.

KARDIOLOGIA POLSKA (2018)

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Review Hematology

Platelet Signaling in Primary Haemostasis and Arterial Thrombus Formation: Part 1

Ruediger E. Scharf

HAMOSTASEOLOGIE (2018)

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Review Medicine, General & Internal

The Platelet Response to Tissue Injury

Felix Eisinger et al.

FRONTIERS IN MEDICINE (2018)

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Article Pharmacology & Pharmacy

Trimucrin, an Arg-Gly-Asp containing disintegrin, attenuates myocardial ischemia-reperfusion injury in murine by inhibiting platelet function

Yu-Chun Hung et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2017)

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Review Physiology

New Concepts and Mechanisms of Platelet Activation Signaling

Brian Estevez et al.

PHYSIOLOGY (2017)

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Article Hematology

Platelet granule release is associated with reactive oxygen species generation during platelet storage: A direct link between platelet pro-inflammatory and oxidation states

Mehran Ghasemzadeh et al.

THROMBOSIS RESEARCH (2017)

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Article Biochemistry & Molecular Biology

Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria

Florian Gaertner et al.

CELL (2017)

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Article Cell Biology

Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype

Tanja Vajen et al.

JOURNAL OF EXTRACELLULAR VESICLES (2017)

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Article Hematology

Platelets and von Willebrand factor in atherogenesis

Melinda D. Wu et al.

BLOOD (2017)

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Article Hematology

Atherosclerotic Plaque Rupture: Identifying the Straw That Breaks the Camel's Back

Yung-Chih Chen et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)

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Article Hematology

Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes

Norbert Gerdes et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)

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Review Hematology

Platelet Interaction with Innate Immune Cells

Julia Barbara Kral et al.

TRANSFUSION MEDICINE AND HEMOTHERAPY (2016)

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Article Biochemistry & Molecular Biology

Platelets Guide Leukocytes to Their Sites of Extravasation

Gabriele Zuchtriegel et al.

PLOS BIOLOGY (2016)

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Article Hematology

Platelets induce apoptosis via membrane-bound FasL

Rebecca I. Schleicher et al.

BLOOD (2015)

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Article Biochemistry & Molecular Biology

The Tyrosine Kinase c-Src Specifically Binds to the Active Integrin IIb3 to Initiate Outside-in Signaling in Platelets

Yibing Wu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

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Review Medicine, General & Internal

Inflammation and plaque vulnerability

G. K. Hansson et al.

JOURNAL OF INTERNAL MEDICINE (2015)

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Article Nanoscience & Nanotechnology

Nanoparticles functionalised with an anti-platelet human antibody for in vivo detection of atherosclerotic plaque by magnetic resonance imaging

Marie-Josee Jacobin-Valat et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2015)

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Review Immunology

Breaking the mold: transcript on factors in the anucleate platelet and platelet-derived microparticles

Katie L. Lannan et al.

FRONTIERS IN IMMUNOLOGY (2015)

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Review Immunology

Are platelets cells? And if yes, are they immune cells?

Olivier Garraud et al.

FRONTIERS IN IMMUNOLOGY (2015)

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Article Hematology

Platelets Mediate Oxidized Low-Density Lipoprotein-Induced Monocyte Extravasation and Foam Cell Formation

Sigrun Badrnya et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)

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Article Cardiac & Cardiovascular Systems

Mechanisms of Plaque Formation and Rupture

Jacob Fog Bentzon et al.

CIRCULATION RESEARCH (2014)

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Article Multidisciplinary Sciences

Platelets and Smooth Muscle Cells Affecting the Differentiation of Monocytes

Michelle W. Y. Williams et al.

PLOS ONE (2014)

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Article Endocrinology & Metabolism

High Fat Diet Induces Adhesion of Platelets to Endothelium in Two Models of Dyslipidemia

Jaime Gonzalez et al.

JOURNAL OF OBESITY (2014)

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Article Hematology

Platelet factor 4 mediates vascular smooth muscle cell injury responses

Guanfang Shi et al.

BLOOD (2013)

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Review Cell Biology

The incredible journey: From megakaryocyte development to platelet formation

Kellie R. Machlus et al.

JOURNAL OF CELL BIOLOGY (2013)

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Article Cardiac & Cardiovascular Systems

Platelets enter atherosclerotic plaque via intraplaque microvascular leakage and intraplaque hemorrhage: A histopathological study in carotid plaques

Guus W. van Lammeren et al.

ATHEROSCLEROSIS (2012)

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Article Hematology

Platelets selectively enhance lymphocyte adhesion on subendothelial matrix under arterial flow conditions

Galia Spectre et al.

THROMBOSIS AND HAEMOSTASIS (2012)

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Article Hematology

Platelet CD36 surface expression levels affect functional responses to oxidized LDL and are associated with inheritance of specific genetic polymorphisms

Arunima Ghosh et al.

BLOOD (2011)

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Article Education, Scientific Disciplines

The Role of Platelets in Atherothrombosis

Zane S. Kaplan et al.

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2011)

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Article Hematology

Concept of Vulnerable/Unstable Plaque

Aloke V. Finn et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2010)

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Article Hematology

Signaling During Platelet Adhesion and Activation

Zhenyu Li et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2010)

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Article Genetics & Heredity

PI3 kinase-dependent stimulation of platelet migration by stromal cell-derived factor 1 (SDF-1)

Bjoern F. Kraemer et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2010)

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Article Hematology

Antithrombotic effects of targeting αIIbβ3 signaling in platelets

Ararat J. Ablooglu et al.

BLOOD (2009)

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Review Cardiac & Cardiovascular Systems

Biology of Platelet-activating Factor Acetylhydrolase (PAF-AH, Lipoprotein Associated Phospholipase A2)

Diana M. Stafforini

CARDIOVASCULAR DRUGS AND THERAPY (2009)

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Article Hematology

Integrins in platelet activation

B. Nieswandt et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2009)

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Article Biochemistry & Molecular Biology

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

Rory R. Koenen et al.

NATURE MEDICINE (2009)

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Review Cardiac & Cardiovascular Systems

Platelet lipoprotein interplay: trigger of foam cell formation and driver of atherosclerosis

Dorothea Siegel-Axel et al.

CARDIOVASCULAR RESEARCH (2008)

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Article Medicine, Research & Experimental

PMNs facilitate translocation of platelets across human and mouse epithelium and together alter fluid homeostasis via epithelial cell-expressed ecto-NTPDases

Thomas Weissmueller et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

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Review Cell Biology

Platelet-lymphocyte cross-talk

Nailin Li

JOURNAL OF LEUKOCYTE BIOLOGY (2008)

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Article Hematology

Transendothelial migration drives dissociation of platelet-monocyte complexes

Janine M. van Gils et al.

THROMBOSIS AND HAEMOSTASIS (2008)

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Article Hematology

PSGL-I regulates platelet P-selectin-mediated endothelial activation and shedding of P-selectin from activated platelets

Vandana S. Dole et al.

THROMBOSIS AND HAEMOSTASIS (2007)

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Article Biochemistry & Molecular Biology

Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype

Eugene A. Podrez et al.

NATURE MEDICINE (2007)

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Article Hematology

Human platelets secrete the plasma type of platelet-activating factor acetylhydrolase primarily associated with microparticles

John V. Mitsios et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)

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Review Medicine, Research & Experimental

Platelets in inflammation and atherogenesis

M Gawaz et al.

JOURNAL OF CLINICAL INVESTIGATION (2005)

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Review Hematology

Integrins: dynamic scaffolds for adhesion and signaling in platelets

SJ Shattil et al.

BLOOD (2004)

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Article Hematology

Platelet physiology and thrombosis

RK Andrews et al.

THROMBOSIS RESEARCH (2004)

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Article Hematology

αIIbβ3 antagonism vs. antiadhesive treatment to prevent platelet interactions with vascular subendothelium

E Melis et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2004)

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Review Cardiac & Cardiovascular Systems

Role of platelets in the development of atherosclerosis

YQ Huo et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2004)

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Review Food Science & Technology

Platelet activating factor - a molecular link between atherosclerosis theories

CA Demopoulos et al.

EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY (2003)

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Article Biochemistry & Molecular Biology

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E

YQ Huo et al.

NATURE MEDICINE (2003)

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Article Immunology

A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation

S Massberg et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2002)

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Article Biochemistry & Molecular Biology

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

J Takagi et al.

CELL (2002)

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Article Critical Care Medicine

The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis

GA Zimmerman et al.

CRITICAL CARE MEDICINE (2002)

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Review Biochemistry & Molecular Biology

Platelet-activating factor acetylhydrolase (PAF-AH)

H Arai et al.

JOURNAL OF BIOCHEMISTRY (2002)

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Review Cardiac & Cardiovascular Systems

The thin-cap fibroatheroma: a type of vulnerable plaque - The major precursor lesion to acute coronary syndromes

FD Kolodgie et al.

CURRENT OPINION IN CARDIOLOGY (2001)

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Article Cardiac & Cardiovascular Systems

RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium

P von Hundelshausen et al.

CIRCULATION (2001)

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Article Immunology

P-selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice

RG Collins et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2000)

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