期刊
CELLS
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/cells11091560
关键词
silencers; chromatin interactions; phase separation
类别
资金
- RNA Biology Center at the Cancer Science Institute of Singapore, NUS, under the Singapore Ministry of Education Academic Research Fund [MOE2014-T3-1-006]
- Singapore Ministry of Education Academic Research Fund Tier 3 grant [MOE2014-T3-1-006]
- NRF Singapore
- Singapore Ministry of Education under its Research Centres of Excellence initiative
- Singapore Ministry of Education Academic Research Fund Tier 2 grant [MOET2EP30120-0009]
This review provides an overview of the current knowledge on human silencers, with a focus on the roles of chromatin interactions and phase separation. The review also proposes future directions for research on human silencers.
Three-dimensional genome organization represents an additional layer in the epigenetic regulation of gene expression. Active transcription controlled by enhancers or super-enhancers has been extensively studied. Enhancers or super-enhancers can recruit activators or co-activators to activate target gene expression through long-range chromatin interactions. Chromatin interactions and phase separation play important roles in terms of enhancer or super-enhancer functioning. Silencers are another major type of cis-regulatory element that can mediate gene regulation by turning off or reducing gene expression. However, compared to active transcription, silencer studies are still in their infancy. This review covers the current knowledge of human silencers, especially the roles of chromatin interactions and phase separation in silencers. This review also proposes future directions for human silencer studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据