☆ 4.6 Review

Cytokines: Can Cancer Get the Message?

CANCERS (2022)

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Article Oncology

Prognostic value of hepatocyte growth factor for muscle-invasive bladder cancer

Satoshi Katayama et al.

Summary: The study assessed the clinical utility of plasma HGF level as a prognostic biomarker in patients with MIBC. The findings indicated that higher HGF levels were associated with worse disease outcomes and could be used to predict prognosis in MIBC patients. However, the absolute magnitude of the effect remained limited.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2022)

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Article Medicine, General & Internal

Magnolol inhibits cancer stemness and IL-6/ Stat3 signaling in oral carcinomas

Chih-Yu Peng et al.

Summary: The study demonstrated that magnolol showed high cytotoxicity against oral squamous cell carcinoma stem cells (OSCC-CSCs) and reduced their cancer stemness features, including self-renewal ability and migration and invasion capacities. Additionally, magnolol enhanced the therapeutic effects of cisplatin.

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION (2022)

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Article Multidisciplinary Sciences

CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory

Yujiro Kidani et al.

Summary: Specific removal of clonally expanding Tregs in tumor tissues for a limited period by cell-depleting anti-CCR8 mAb treatment can generate potent tumor immunity without causing deleterious autoimmunity. This approach can induce memory-type tumor-specific effector T cells while avoiding severe autoimmune diseases, resulting in long-lasting tumor immunity.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Pharmacology & Pharmacy

Nicotine stimulates IL-8 expression via ROS/NF-κB and ROS/MAPK/AP-1 axis in human gastric cancer cells

Sen Lian et al.

Summary: This study found that nicotine induces IL-8 expression via the ROS/NF-kappa B and ROS/MAPK (Erk1/2, p38)/AP-1 axis in gastric cancer cells, thus stimulating endothelial cell proliferation and angiogenesis in the tumor microenvironment.

TOXICOLOGY (2022)

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Review Oncology

Hallmarks of Cancer: New Dimensions

Douglas Hanahan

Summary: The concept of the hallmarks of cancer is a tool for simplifying the complexity of cancer phenotypes and genotypes into basic principles. This article proposes phenotypic plasticity and disrupted differentiation as distinct hallmark capabilities, and discusses nonmutational epigenetic reprogramming and polymorphic microbiomes as enabling characteristics. Additionally, the importance of senescent cells in the tumor microenvironment is highlighted. The integrative concept of the hallmarks of cancer helps in understanding the mechanisms of cancer development and applying that knowledge to cancer medicine.

CANCER DISCOVERY (2022)

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Review Oncology

Tumor-associated macrophages: An important player in breast cancer progression

Xinqun Huang et al.

Summary: In breast cancer, tumor-associated macrophages (TAMs) play a crucial role in promoting tumor growth through various mechanisms, but can promote tumor regression by repolarizing into M1 macrophages. TAMs are established as effective targets for breast cancer treatment.

THORACIC CANCER (2022)

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Article Oncology

PFKFB4 promotes angiogenesis via IL-6/STAT5A/P-STAT5 signaling in breast cancer

Dan Li et al.

Summary: Breast cancer is a major global health concern, and the process of angiogenesis and metastasis plays a crucial role in its progression. This study investigates the role of PFKFB4 in breast cancer angiogenesis and provides evidence that PFKFB4 regulates IL-6 expression and lactate secretion to promote angiogenesis. Furthermore, a specific PFKFB4 inhibitor, 5-MPN, is found to suppress angiogenesis, suggesting its potential as a therapeutic strategy for breast cancer patients.

JOURNAL OF CANCER (2022)

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Article Biotechnology & Applied Microbiology

Angiopoietin-like 3 (ANGPTL3) drives cell proliferation, migration and angiogenesis in cervical cancer via binding to integrin alpha v beta 3

Lijun Zhong et al.

Summary: It has been discovered that ANGPTL3 plays an oncogenic role in several types of human malignancies. This study found that ANGPTL3 is highly expressed in cervical cancer cells and silencing ANGPTL3 can inhibit cell proliferation, migration, invasion, and angiogenesis. The inhibitory effect of ANGPTL3 can be offset by upregulating the expression of alpha v beta 3, which also promotes blood vessel formation and the secretion of VEGF and VEGFR2 in cervical cancer cells.

BIOENGINEERED (2022)

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Review Oncology

The Emerging Role of c-Met in Carcinogenesis and Clinical Implications as a Possible Therapeutic Target

Antonio Faiella et al.

Summary: The translation provides an overview of the importance and therapeutic applications of c-MET in tumors. c-MET has potential roles in tumor treatment and may become a new strategy for targeted therapy.

JOURNAL OF ONCOLOGY (2022)

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Review Oncology

Targeting interleukin-1β and inflammation in lung cancer

Jun Zhang et al.

Summary: Inflammation is a process that protects organs and enables repair, but dysregulated inflammation leads to diseases like cancer. Cancer-related inflammation modulates the tumor microenvironment, an important factor in tumor progression, and targeting its immune component is the basis of immunotherapy. Blocking interleukin-1 beta has shown promise in reducing the incidence of lung cancer, opening up a new avenue for lung cancer therapy.

BIOMARKER RESEARCH (2022)

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Article Medicine, General & Internal

Efficiency of anti-VEGF therapy in central nervous system AML relapse: A case report and literature review

Han-Yu Cao et al.

Summary: There is limited research on the treatment of central nervous system acute myeloid leukemia relapse. This case study suggests that combining bevacizumab with intrathecal chemotherapy as maintenance therapy may be a viable treatment option for CNS leukemia patients.

CLINICAL CASE REPORTS (2022)

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Article Oncology

Breast cancer metastasis: immune profiling of lymph nodes reveals exhaustion of effector T cells and immunosuppression

Inga Hansine Rye et al.

Summary: This study found that metastatic lymph nodes had a significantly increased frequency of CD8 T cells, indicating an ongoing immune response, and also suggested exhaustion of effector T cells. Additionally, there was an increased frequency of regulatory T cells (Tregs) with an activated phenotype in metastatic lymph nodes.

MOLECULAR ONCOLOGY (2022)

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Review Oncology

IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment

Sara G. Manore et al.

Summary: Breast cancer, the most commonly diagnosed cancer in women, often metastasizes due to the IL-6-mediated signaling pathway. Abnormal activation of this pathway promotes breast cancer metastasis while suppressing the anti-tumor immune response. Components of the IL-6 pathway are potential targets for cancer therapeutics.

FRONTIERS IN ONCOLOGY (2022)

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Review Urology & Nephrology

VEGF inhibition in urothelial cancer: the past, present and future

Sanaz Ghafouri et al.

Summary: Anti-angiogenic agents have shown promise in treating locally advanced or metastatic urothelial cancer, but further research is needed to determine ideal treatment combinations in order to maximize benefits for selected patient populations.

WORLD JOURNAL OF UROLOGY (2021)

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Review Pharmacology & Pharmacy

Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression

Kristen Fousek et al.

Summary: IL-8 plays a significant role in the tumor microenvironment by affecting tumor cell proliferation, invasiveness, drug resistance, and immune cell killing capacity, thereby impacting the efficacy of immunotherapy.

PHARMACOLOGY & THERAPEUTICS (2021)

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Review Immunology

Cytokine Regulation and Function in T Cells

Chen Dong

Summary: T lymphocytes play a key role in cellular immunity, with significant heterogeneity in CD4(+) T cells leading to the identification of various subsets with unique roles in immunity and pathology. Understanding cytokine regulation and function has provided innovative treatment options for many human diseases.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 39 (2021)

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Article Oncology

M2 macrophages secrete CXCL13 to promote renal cell carcinoma migration, invasion, and EMT

Yingwei Xie et al.

Summary: This study found that M2 macrophages in clear cell renal cell carcinoma are associated with poor prognosis, potentially promoting tumor proliferation, migration, and invasion through the secretion of chemokine CXCL13.

CANCER CELL INTERNATIONAL (2021)

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Review Chemistry, Medicinal

Inhibitors of gelatinases (MMP-2 and MMP-9) for the management of hematological malignancies

Sanjib Das et al.

Summary: Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) play significant roles in solid tumor invasion, metastasis, and angiogenesis, while their role in hematological malignancies is less understood. Recent studies have shown correlations between gelatinases and hematological malignancies, leading to the development of potential inhibitors for these conditions.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Review Oncology

3D tumor angiogenesis models: recent advances and challenges

Sharath M. Bhat et al.

Summary: Angiogenesis is a complex process that plays a crucial role in tumor growth and metastasis. Various independent mechanisms inducing angiogenesis in tumors have been identified, including HIF-1/VEGF mediated paracrine interactions and recruitment of endothelial cells. However, existing angiogenesis models often rely on normal endothelial cells, which differ significantly from tumor endothelial cells, highlighting the need for improved models in personalized medicine.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2021)

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Article Engineering, Biomedical

Diagnostic and prognostic value of placental growth factor serum concentration in clear cell renal cell carcinoma

Marcela Cechova et al.

Summary: PlGF serum concentration is significantly higher in patients with ccRCC, indicating its potential diagnostic and prognostic value. PlGF concentration is associated with the risk and relapse of ccRCC, with lower levels potentially linked to higher cancer-specific survival rates.

BIOMEDICAL PAPERS-OLOMOUC (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Biochemistry & Molecular Biology

A Structural Overview of Vascular Endothelial Growth Factors Pharmacological Ligands: From Macromolecules to Designed Peptidomimetics

Xiaoqing Ye et al.

Summary: The VEGF family of growth factors plays a crucial role in vasculogenesis and angiogenesis, with blocking ligands developed to study their activities and potential therapeutic applications in cancer and age-related macular degeneration. There is a trend towards developing smaller ligands like nanobodies and peptides with improved properties such as serum stability and greater affinity, but there is still a scarcity of small molecular entities and a lack of small organic molecule ligands targeting VEGF members other than VEGF-A. Future developments in this area are expected in the coming years.

MOLECULES (2021)

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Article Biochemistry & Molecular Biology

Nano formulated Resveratrol inhibits metastasis and angiogenesis by reducing inflammatory cytokines in oral cancer cells by targeting tumor associated macrophages

Rajalaxmi Pradhan et al.

Summary: Tumor associated macrophages in the tumor microenvironment secrete cytokines that regulate cancer cells growth, while Resveratrol nanoparticles reduce the properties of cancer stem like cells. By decreasing cytokine levels, Res-NP inhibits invasion, proliferation, and growth of CSCs in vitro, in vivo, and ex vivo systems.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

IL-6 and IL-8, secreted by myofibroblasts in the tumor microenvironment, activate HES1 to expand the cancer stem cell population in early colorectal tumor

Bun Kim et al.

Summary: The study found that factors released from myofibroblasts may increase CSCs through IL-6/IL-8-induced HES1 activation in the tumor microenvironment, which might be mediated via the Notch/HES1 and STAT3 signaling pathways.

MOLECULAR CARCINOGENESIS (2021)

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Article Oncology

Escin inhibits angiogenesis by suppressing interleukin-8 and vascular endothelial growth factor production by blocking nuclear factor-κB activation in pancreatic cancer cell lines

Kan Omi et al.

Summary: The study confirmed that escin inhibits angiogenesis in pancreatic cancer by reducing the secretion of IL-8 and VEGF through blocking NF-kappa B activity. This suggests that escin could be a novel molecular therapy for pancreatic cancer.

ONCOLOGY REPORTS (2021)

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Review Ophthalmology

VEGFR1 signaling in retinal angiogenesis and microinflammation

Akiyoshi Uemura et al.

Summary: VEGFR1 and its ligands play important roles in angiogenesis and microinflammatory cascades within the retina, but the mechanisms of their actions remain unclear, the competition for receptor binding and heterodimerization complicates the understanding of their relative contributions.

PROGRESS IN RETINAL AND EYE RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Propofol inhibits tumor angiogenesis through targeting VEGF/VEGFR and mTOR/eIF4E signaling

Zhibao Wang et al.

Summary: Propofol inhibits tubular structure formation and various biological functions of tumor-associated endothelial cells, including migration, adhesion, proliferation, and survival, by suppressing the expression and secretion of multiple pro-angiogenic factors and specific signaling pathways. These findings provide preclinical evidence for the anti-cancer properties of propofol and its potential mechanisms in inhibiting tumor growth and metastasis.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Hematology

Assessment of endothelial progenitor cells, VEGF-A and SDF-1α in Hodgkin's lymphoma

Jan Filipiak et al.

Summary: The study assesses the number of endothelial progenitor cells (EPCs) and selected cytokines in Hodgkin's lymphoma patients, showing significantly higher EPCs number and VEGF-A concentration compared to healthy individuals, with a positive correlation between EPCs and VEGF-A. This suggests a potential stimulation of new blood vessel formation in Hodgkin's lymphoma patients before the first treatment, contributing to tumor growth and metastasis.

BLOOD COAGULATION & FIBRINOLYSIS (2021)

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Article Oncology

Deregulation of angiopoietin-like 4 slows ovarian cancer progression through vascular endothelial growth factor receptor 2 phosphorylation

Yuxian Wu et al.

Summary: The study showed that upregulation of ANGPTL4 in ovarian cancer cells led to increased tumor angiogenesis, growth, and metastasis inhibition. Inactivation of VEGFR2 Y949 phosphorylation eliminated the tumor-suppressive effects of ANGPTL4 inhibition in spontaneous ovarian carcinoma.

CANCER CELL INTERNATIONAL (2021)

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Article Immunology

CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function

Sarah K. Whiteside et al.

Summary: CCR8 function is not essential for Treg cell accumulation and immunosuppressive function within tumors, suggesting that depletion of CCR8(+) Treg cells rather than blockade of CCR8 function may be a more promising avenue for selective immunotherapy.

IMMUNOLOGY (2021)

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Article Hematology

Risk stratification model based on VEGF and International Prognostic Index accurately identifies low-risk diffuse large B-cell lymphoma patients in the rituximab era

Wei Sang et al.

Summary: The study demonstrated that VEGF predicts therapeutic response in DLBCL and the V-IPI model based on VEGF and IPI accurately predicts the PFS rate of low-risk DLBCL in the era of rituximab.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2021)

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Review Biochemistry & Molecular Biology

Metalloproteinases in Ovarian Cancer

Preston Carey et al.

Summary: Proteases, particularly those of the matrix metalloproteinase family, play a crucial role in ovarian cancer progression and metastasis by enhancing migratory ability, ECM breakdown, and tumor support system development. Upregulation of certain proteases influences angiogenesis for tumor growth and development of metastatic implants.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

IL-6/STAT3 Is a Promising Therapeutic Target for Hepatocellular Carcinoma

Junnv Xu et al.

Summary: IL-6 plays a crucial role in the occurrence and development of hepatocellular carcinoma (HCC), and targeting the IL-6/STAT3 signaling pathway is essential for therapy. Several inhibitors of IL-6/STAT3 have been developed for cancer treatment.

FRONTIERS IN ONCOLOGY (2021)

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Review Immunology

Differentiation and Regulation of TH Cells: A Balancing Act for Cancer Immunotherapy

Amrita Basu et al.

Summary: This review highlights the importance of T-H cells in cancer immunotherapy, discussing the regulation of different subtypes by various immune cells and the impact of contradictory signals on treatment outcomes. Understanding the complexities of CD4(+) T-H cells and balancing anti- vs pro-tumorigenic subtypes is crucial for designing effective immunotherapies.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Oncology

The Role of Macrophages in Cancer Development and Therapy

Ewa Cendrowicz et al.

Summary: Tumor-Associated Macrophages (TAMs) play a crucial role in tumor development and are potential targets for cancer therapy due to their influence on immunity and tumor microenvironment.

CANCERS (2021)

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Review Biochemistry & Molecular Biology

Regulation of Cancer Metastasis by TRAIL/Death Receptor Signaling

You-Take Oh et al.

Summary: The involvement of the TRAIL/death receptor signaling pathway in the regulation of cancer invasion and metastasis is complex, with both positive and negative roles reported. The underlying molecular mechanisms are even more complicated. This review focuses on discussing the current understanding of how TRAIL/death receptor-mediated signaling regulates cancer cell invasion and metastasis.

BIOMOLECULES (2021)

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Article Oncology

E-Cadherin and Angiopoietin-2 as Potential Biomarkers for Colorectal Cancer With Peritoneal Carcinomatosis

Hee Kyung Kim et al.

Summary: This study found significantly increased levels of soluble E-Cadherin and ANGPT2 in plasma and malignant ascites of colorectal cancer (CRC) patients with peritoneal carcinomatosis (PC), which were negatively associated with overall survival. These findings suggest that soluble E-Cadherin and ANGPT2 may serve as surrogate biomarkers for clinical outcome in CRC patients with PC.

ANTICANCER RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Macrophage Polarization States in the Tumor Microenvironment

Ava J. Boutilier et al.

Summary: The M1/M2 macrophage paradigm is crucial in tumor progression, where M1 macrophages have anti-tumor effects and M2 macrophages contribute to tumor development through various mechanisms. The tumor microenvironment plays a role in influencing macrophage polarization and activation, which is essential for understanding the pro-tumor effects of tumor-associated macrophages.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Interleukin-1β Induces Tissue Factor Expression in A549 Cells via EGFR-Dependent and -Independent Mechanisms

Tobias Mechelke et al.

Summary: The study found that IL-1 beta induces TF expression in lung cancer cells through multiple signaling pathways, including EGFR and MAPK pathways. Inhibition of EGFR can reduce TF expression and suppress the activation of p42/44 MAPK and EGFR.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Chemistry, Medicinal

Research progress of phenolic compounds regulating IL-6 to exert antitumor effects

Tingting Xia et al.

Summary: Cytokine therapy, focusing on the regulation of IL-6, shows potential as a novel approach in cancer treatment, but more high-quality clinical studies are needed to validate its efficacy.

PHYTOTHERAPY RESEARCH (2021)

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Article Multidisciplinary Sciences

Genetics of PlGF plasma levels highlights a role of its receptors and supports the link between angiogenesis and immunity

Daniela Ruggiero et al.

Summary: The study measured PlGF plasma levels in 2085 adults from three isolated populations in South Italy. A significant signal associated with PlGF levels was found in the NRP1 gene, with additional signals identified in the FLT1 and RAPGEF5 genes. Pathway and TWAS analyses supported the link between angiogenesis, immune response, and PlGF regulation.

SCIENTIFIC REPORTS (2021)

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Article Oncology

Curcumin in Combination With Omacetaxine Suppress Lymphoma Cell Growth, Migration, Invasion, and Angiogenesis via Inhibition of VEGF/Akt Signaling Pathway

Yu Zhang et al.

Summary: The combination of HHT and curcumin showed significant inhibitory effects on the proliferation, migration, and invasion of lymphoma cells, as well as the secretion of VEGF. Additionally, the combination treatment inhibited the VEGF/Akt signaling pathway, affecting the growth and angiogenesis of lymphoma cells and endothelial cells. These results suggest that HHT combined with curcumin may be a promising therapeutic approach for lymphoma treatment.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

Linking Tumor Microenvironment to Plasticity of Cancer Stem Cells: Mechanisms and Application in Cancer Therapy

Xiaobo Zheng et al.

Summary: Cancer stem cells (CSCs) are a subset of cancer cells that drive tumor initiation, progression, and drug resistance. They exhibit plasticity, altering their phenotype and function, contributing to tumor relapse and metastasis. The tumor microenvironment (TME) plays a crucial role in regulating CSC plasticity, impacting cancer progression and drug resistance.

FRONTIERS IN ONCOLOGY (2021)

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Review Medicine, General & Internal

Update Overview of the Role of Angiopoietins in Lung Cancer

Dimitris Tsakogiannis et al.

Summary: Angiopoietins play a crucial role in the development and progression of non-small-cell lung carcinomas (NSCLC), affecting tumor angiogenesis, lymphangiogenesis, metastasis, and prognosis. Their levels can be valuable in determining the most suitable therapeutic strategy for lung cancer patients. Further investigation is needed to understand the roles of Angiopoietin-1 and Angiopoietin-4 in NSCLC development.

MEDICINA-LITHUANIA (2021)

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Article Biochemistry & Molecular Biology

TNF-α augments CXCL10/CXCR3 axis activity to induce Epithelial-Mesenchymal Transition in colon cancer cell

Zhengcheng Wang et al.

Summary: Chronic inflammation-induced metastases in cancer have been a significant obstacle in treatment. Recent studies have shown that TNF-alpha activates PI3K/Akt and p38 MAPK pathways to enhance CXCL10 transcription, promoting metastases in colon cancer cells. CXCL10, in turn, regulates EMT in colon cancer cells via the PI3K/Akt pathway, offering a new potential target for inhibiting colon cancer metastases.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Chemistry, Medicinal

Clinical Application of Cytokines in Cancer Immunotherapy

Yi Qiu et al.

Summary: Cytokines play crucial roles in the immune response to cancer and hold promise for precise cancer treatment. Clinical studies have shown progress in the use of cytokine-based drugs for cancer therapy, focusing on improving delivery efficiency, stability, biocompatibility, and availability.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

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Review Oncology

Interleukins in cancer: from biology to therapy

Dania Briukhovetska et al.

Summary: This article provides an update on the role of interleukins in tumor biology, highlighting their significance in cancer development, progression, and immunotherapy. Interleukins can both promote cancer growth and enhance tumor-directed immune responses, making them a valuable target for improving treatment effectiveness and reducing side effects.

NATURE REVIEWS CANCER (2021)

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Review Biochemistry & Molecular Biology

Dysregulation of Type II Transmembrane Serine Proteases and Ligand-Dependent Activation of MET in Urological Cancers

Shoichiro Mukai et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis

Timothy O. Adekoya et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Multidisciplinary Sciences

Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients

Nicolas Gonzalo Nunez et al.

NATURE COMMUNICATIONS (2020)

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Article Biochemistry & Molecular Biology

Development of a Recombinant Monospecific Anti-PLGF Bivalent Nanobody and Evaluation of it in Angiogenesis Modulation

Abolfazl Nikooharf et al.

MOLECULAR BIOTECHNOLOGY (2020)

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Article Oncology

Roles of Fibroblast Activation Protein and Hepatocyte Growth Factor Expressions in Angiogenesis and Metastasis of Gastric Cancer

Li-Ming Gao et al.

PATHOLOGY & ONCOLOGY RESEARCH (2019)

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Review Oncology

Regulatory T cells in cancer immunosuppression - implications for anticancer therapy

Yosuke Togashi et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

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Review Oncology

Cancer-associated fibroblast regulation of tumor neo-angiogenesis as a therapeutic target in cancer

Fang-Tao Wang et al.

ONCOLOGY LETTERS (2019)

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Article Gastroenterology & Hepatology

Propofol inhibits pancreatic cancer progress under hypoxia via ADAM8

Yutong Gao et al.

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES (2019)

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Review Immunology

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

Florian R. Greten et al.

IMMUNITY (2019)

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Article Multidisciplinary Sciences

Immune evasion before tumour invasion in early lung squamous carcinogenesis

Celine Mascaux et al.

NATURE (2019)

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Article Multidisciplinary Sciences

A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours

Rong Fu et al.

NATURE COMMUNICATIONS (2019)

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Review Medical Laboratory Technology

HGF/MET pathway aberrations as diagnostic, prognostic, and predictive biomarkers in human cancers

Fatemeh Moosavi et al.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2019)

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Review Oncology

Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy

Maria Teresa Masucci et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Biochemistry & Molecular Biology

Breast Cancer Metastasis: Are Cytokines Important Players During Its Development and Progression?

Lucia Angelica Mendez-Garcia et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2019)

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Review Immunology

Th17 Cells Paradoxical Roles in Melanoma and Potential Application in Immunotherapy

Chen Chen et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Biotechnology & Applied Microbiology

Tumor-associated macrophage-derived cytokines enhance cancer stem-like characteristics through epithelial-mesenchymal transition

Yongxu Chen et al.

ONCOTARGETS AND THERAPY (2018)

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Article Oncology

Cancer cell plasticity: Impact on tumor progression and therapy response

Victoria da Silva-Diz et al.

SEMINARS IN CANCER BIOLOGY (2018)

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Review Cardiac & Cardiovascular Systems

Tumor Necrosis Factor- in Heart Failure: an Updated Review

Sarah M. Schumacher et al.

CURRENT CARDIOLOGY REPORTS (2018)

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Article Biochemistry & Molecular Biology

Epidermal growth factor-induced ANGPTL4 enhances anoikis resistance and tumour metastasis in head and neck squamous cell carcinoma

Y-H Liao et al.

ONCOGENE (2017)

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Review Biochemistry & Molecular Biology

Crosstalk between DNA Damage and Inflammation in the Multiple Steps of Carcinogenesis

Shosuke Kawanishi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Immunology

An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition

Helen L. Young et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Article Medicine, General & Internal

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

P. M. Ridker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Oncology

Exposure to TNF-α combined with TGF-β induces carcinogenesis in vitro via NF-κB/Twist axis

Weilei Dong et al.

ONCOLOGY REPORTS (2017)

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Article Pharmacology & Pharmacy

Colon cancer-derived myofibroblasts increase endothelial cell migration by glucocorticoid-sensitive secretion of a pro-migratory factor

Zuzanna Drebert et al.

VASCULAR PHARMACOLOGY (2017)

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Article Oncology

Clinical impact of high serum hepatocyte growth factor in advanced non-small cell lung cancer

Takahiro Tsuji et al.

ONCOTARGET (2017)

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Review Oncology

TAMeless traitors: macrophages in cancer progression and metastasis

Shweta Aras et al.

BRITISH JOURNAL OF CANCER (2017)

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Article Pharmacology & Pharmacy

Cancer cell and macrophage cross-talk in the tumor microenvironment

Nathalie Dehnel et al.

CURRENT OPINION IN PHARMACOLOGY (2017)

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Article Immunology

Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer

George Plitas et al.

IMMUNITY (2016)

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Review Oncology

Tumor angiogenesis-characteristics of tumor endothelial cells

Kyoko Hida et al.

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2016)

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Identification and characterization of a novel nanobody against human placental growth factor to modulate angiogenesis

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MOLECULAR IMMUNOLOGY (2016)

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Review Oncology

Hypoxia: Signaling the Metastatic Cascade

Erinn B. Rankin et al.

TRENDS IN CANCER (2016)

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Review Oncology

Tumor-associated macrophages: unwitting accomplices in breast cancer malignancy

Carly Bess Williams et al.

NPJ BREAST CANCER (2016)

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The 3 major types of innate and adaptive cell-mediated effector immunity

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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

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Review Oncology

New Findings on Breast Cancer Stem Cells: A Review

Azam Bozorgi et al.

JOURNAL OF BREAST CANCER (2015)

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Letter Dermatology

Real-time imaging of interaction between macrophages and lymphatic vessels in an in vitro model to study inflammatory resolution

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JOURNAL OF DERMATOLOGICAL SCIENCE (2015)

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Article Medicine, Research & Experimental

Propofol-enhanced autophagy increases motility and angiogenic capacity of cultured human umbilical vascular endothelial cells

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LIFE SCIENCES (2015)

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Review Biotechnology & Applied Microbiology

Th17 Cell Plasticity and Functions in Cancer Immunity

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BIOMED RESEARCH INTERNATIONAL (2015)

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Article Gastroenterology & Hepatology

Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells

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GASTROENTEROLOGY (2014)

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Article Oncology

A Macrophage-Dominant PI3K Isoform Controls Hypoxia-Induced HIF1α and HIF2α Stability and Tumor Growth, Angiogenesis, and Metastasis

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MOLECULAR CANCER RESEARCH (2014)

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Review Immunology

The two faces of IL-6 in the tumor microenvironment

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SEMINARS IN IMMUNOLOGY (2014)

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IL-10: Master Switch from Tumor-Promoting Inflammation to Antitumor Immunity

Martin Oft

CANCER IMMUNOLOGY RESEARCH (2014)

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Role of tumor assocaited macrophages in tumor angiogenesis and lymphangiogenesis

Vladimir Riabov et al.

FRONTIERS IN PHYSIOLOGY (2014)

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A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency

Benedicte Neven et al.

BLOOD (2013)

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Sustained Exposure to Cytokines and Hypoxia Enhances Excitability of Oxygen-Sensitive Type I Cells in Rat Carotid Body: Correlation with the Expression of HIF-1α Protein and Adrenomedullin

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HIGH ALTITUDE MEDICINE & BIOLOGY (2013)

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Review Immunology

Oncology Meets Immunology: The Cancer-Immunity Cycle

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IMMUNITY (2013)

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Control of inflammation by integration of environmental cues by regulatory T cells

Ashutosh Chaudhry et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

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Article Immunology

The Role of IL-1β in the Early Tumor Cell-Induced Angiogenic Response

Yaron Carmi et al.

JOURNAL OF IMMUNOLOGY (2013)

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Article Oncology

Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis

Y. S. Lee et al.

BRITISH JOURNAL OF CANCER (2012)

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Article Oncology

A phase I, dose-escalation study of TB-403, a monoclonal antibody directed against PlGF, in patients with advanced solid tumours

U. Lassen et al.

BRITISH JOURNAL OF CANCER (2012)

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Review Oncology

Anoikis: an emerging hallmark in health and diseases

M. L. Taddei et al.

JOURNAL OF PATHOLOGY (2012)

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Merkel cell carcinoma induces lymphatic microvessel formation

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JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2012)

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Inflammation and Cancer: A Comparative View

Wallace B. Morrison

JOURNAL OF VETERINARY INTERNAL MEDICINE (2012)

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TNF-α Induces Epithelial-Mesenchymal Transition of Renal Cell Carcinoma Cells via a GSK3β-Dependent Mechanism

Ming-Yi Ho et al.

MOLECULAR CANCER RESEARCH (2012)

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Glioblastoma Cell-Secreted Interleukin-8 Induces Brain Endothelial Cell Permeability via CXCR2

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PLOS ONE (2012)

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Article Oncology

Inflammatory mediators in breast cancer: Coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition

Gali Soria et al.

BMC CANCER (2011)

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Article Oncology

CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3

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CANCER CELL (2011)

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Review Oncology

The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by Tumor-Vascular Disrupting Agents

Dietmar W. Siemann

CANCER TREATMENT REVIEWS (2011)

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NOTCH Signaling Is Required for Formation and Self-Renewal of Tumor-Initiating Cells and for Repression of Secretory Cell Differentiation in Colon Cancer

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CANCER RESEARCH (2010)

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MMP-2 alters VEGF expression via αVβ3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells

Chandramu Chetty et al.

INTERNATIONAL JOURNAL OF CANCER (2010)

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TNFalpha Up-Regulates SLUG Via the NF-kappaB/HIF1alpha Axis, Which Imparts Breast Cancer Cells With a Stem Cell-Like Phenotype

Gianluca Storci et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2010)

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Review Immunology

IL-17 and Th17 Cells

Thomas Korn et al.

ANNUAL REVIEW OF IMMUNOLOGY (2009)

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Review Biochemistry & Molecular Biology

Metastasis mechanisms

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BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2009)

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Serum hepatocyte growth factor as a prognostic marker for stage II or III colorectal cancer patients

Yuji Toiyama et al.

INTERNATIONAL JOURNAL OF CANCER (2009)

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Review Immunology

Structure and signalling in the IL-17 receptor family

Sarah L. Gaffen

NATURE REVIEWS IMMUNOLOGY (2009)

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Review Oncology

Tumour necrosis factor and cancer

Frances Balkwill

NATURE REVIEWS CANCER (2009)

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Review Oncology

The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages

Paola Allavena et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2008)

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Article Immunology

Re-educating tumor-associated macrophages by targeting NF-κB

Thorsten Hagemann et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

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Review Multidisciplinary Sciences

Cancer-related inflammation

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NATURE (2008)

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Article Oncology

Transforming growth factor-β and the immune response:: Implications for anticancer therapy

Stephen H. Wrzesinski et al.

CLINICAL CANCER RESEARCH (2007)

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Cytokines, Inflammation, and Pain

Jun-Ming Zhang et al.

INTERNATIONAL ANESTHESIOLOGY CLINICS (2007)

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Article Gastroenterology & Hepatology

Elevated level of interleukin-6 predicts organ failure and severe disease in patients with acute pancreatitis

Garipati Sathyanarayan et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2007)

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Article Oncology

Inhibitor of apoptosis proteins are regulated by tumour necrosis factor-alpha in malignant pleural mesothelioma

G. J. Gordon et al.

JOURNAL OF PATHOLOGY (2007)

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Review Hematology

Understanding the biology of angiogenesis: Review of the most important molecular mechanisms

Zaher K. Otrock et al.

BLOOD CELLS MOLECULES AND DISEASES (2007)

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Article Biochemistry & Molecular Biology

The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells

Ivaylo I. Ivanov et al.

CELL (2006)

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Review Oncology

Inflammation, a key event in cancer development

HT Lu et al.

MOLECULAR CANCER RESEARCH (2006)

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Review Oncology

Pro-angiogenic cytokines and their role in tumor angiogenesis

Gera Neufeld et al.

CANCER AND METASTASIS REVIEWS (2006)

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Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion

Somchai Pinlaor et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2005)

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Article Multidisciplinary Sciences

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivoi

ML Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Biological characterization of angiopoietin-3 and angiopoietin-4

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FASEB JOURNAL (2004)

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Chemical basis of inflammation-induced carcinogenesis

H Ohshima et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2003)

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Interleukin-10 therapy - Review of a new approach

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PHARMACOLOGICAL REVIEWS (2003)

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IL-1 is required for tumor invasiveness and angiogenesis

E Voronov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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3D microvascular architecture of pre-cancerous lesions and invasive carcinomas of the colon

MA Konerding et al.

BRITISH JOURNAL OF CANCER (2001)

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Response of psoriasis to interleukin-10 is associated with suppression of cutaneous type 1 inflammation, downregulation of the epidermal interleukin-8/CXCR2 pathway and normalization of keratinocyte maturation

K Reich et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2001)

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Article Multidisciplinary Sciences

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

ZJ Zhou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

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Article Multidisciplinary Sciences

Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model

JM Fang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

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