4.6 Review

Vitamin D and Hypoxia: Points of Interplay in Cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

An update on vitamin D signaling and cancer

Carsten Carlberg et al.

Summary: A low vitamin D status is associated with an increased risk of various cancers. The biologically active form of vitamin D, 1,25(OH)2D3, influences the epigenome and transcriptome of healthy and neoplastic cells, affecting their growth and differentiation.

SEMINARS IN CANCER BIOLOGY (2022)

Editorial Material Oncology

Hypoxia-Inducible Factors in Cancer

Laura C. Kim et al.

CANCER RESEARCH (2022)

Review Biochemistry & Molecular Biology

ERp57/PDIA3: new insight

Silvia Chichiarelli et al.

Summary: The ERp57/PDIA3 protein, a member of the PDIs family, is found in various subcellular locations and is involved in multiple physiological and pathological processes. This review presents new insights into its functions and summarizes PDIA3-specific inhibitors.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2022)

Article Biochemistry & Molecular Biology

USP33 deubiquitinates and stabilizes HIF-2alpha to promote hypoxia response in glioma stem cells

Aili Zhang et al.

Summary: In this study, USP33 was identified as an essential deubiquitinase that stabilizes HIF-2alpha protein in an ERK1/2-dependent manner to promote hypoxia response in cancer cells. Our findings highlight the role of USP33 as a regulator of hypoxia response in cancer stem cells, indicating its potential as a therapeutic target for brain tumor treatment.

EMBO JOURNAL (2022)

Article Biology

Calcitriol Suppresses Warburg Effect and Cell Growth in Human Colorectal Cancer Cells

Chun-Yin Huang et al.

Summary: The biologically active form of vitamin D, calcitriol, has been found to suppress cancer progression by reducing cell proliferation, increasing cell differentiation, and inhibiting angiogenesis. Research indicates that calcitriol can suppress glycolysis and cell growth in human colorectal cancer cells, leading to smaller tumors.

LIFE-BASEL (2021)

Article Biochemistry & Molecular Biology

Hypoxia as a modulator of cytochromes P450: Overexpression of the cytochromes CYP2S1 and CYP24A1 in human liver cancer cells in hypoxia

Alfredo Cabrera-Cano et al.

Summary: The study revealed that in liver cancer, the expression of CYP2S1 and CYP24A1 is induced under hypoxic conditions. This may have implications for cancer progression and drug resistance.

CELL BIOCHEMISTRY AND FUNCTION (2021)

Article Oncology

Celastrol in cancer therapy: Recent developments, challenges and prospects

Hannah Ying Lim et al.

Summary: The review summarizes the potential and mechanisms of celastrol in cancer treatment, discusses the obstacles hindering its use in humans, and provides insights into future directions for research and development.

CANCER LETTERS (2021)

Review Biochemistry & Molecular Biology

The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity

Adam Albanese et al.

Summary: The hypoxia signaling pathway allows cells to adapt to decreased oxygen availability, with HIF transcription factors playing a crucial role in inducing the expression of hypoxia-regulated genes. In addition to hydroxylation, other post-translational modifications of HIF also play a crucial role in altering its localization, stability, and activity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Oncology

Specific Inhibition of HIF Activity: Can Peptides Lead the Way?

Ilias Mylonis et al.

Summary: Hypoxia inducible transcription factors (HIFs) play a critical role in enabling cancer cells to thrive in low oxygen conditions. Inhibiting HIFs can prevent cancer cell growth and metastasis, with peptide HIF inhibitors showing potential as highly selective therapeutic agents. This review highlights the importance of targeting HIFs in cancer treatment and the promising development of peptide inhibitors.

CANCERS (2021)

Review Genetics & Heredity

Heritable disorders of oxygen sensing

Gregg L. Semenza

Summary: Hypoxia-inducible factors (HIFs) activate gene transcription in response to low oxygen levels, playing critical roles in development, physiology, and disease pathogenesis. Mutations causing dysregulated HIF activity are responsible for tumor susceptibility in von Hippel-Lindau syndrome and excessive red blood cell production in hereditary erythrocytosis.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2021)

Article Biochemistry & Molecular Biology

Inhibition of calcitriol inactivating enzyme CYP24A1 gene expression by flavonoids in hepatocellular carcinoma cells under normoxia and hypoxia

Antonia Eugenia Angeli-Terzidou et al.

Summary: The active form of vitamin D, calcitriol, shows potential as an anticancer agent, but overexpressed CYP24A1 hydroxylase in cancer cells may counteract this effect. Isoflavones, particularly genistein, have been found to effectively suppress the expression of the CYP24A1 gene induced by calcitriol in hypoxic conditions, which are characteristic of solid tumors.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021)

Article Biochemistry & Molecular Biology

Novel HIF-2α interaction with Reptin52 impairs HIF-2 transcriptional activity and EPO secretion

Ioanna Maria Gkotinakou et al.

Summary: Hypoxia-inducible factor 2 (HIF-2) plays a crucial role in cellular response to low oxygen levels and interacts with Reptin52 to affect cellular functions, primarily in the cytoplasm. This interaction can modulate HIF-2 transcriptional activity, leading to changes in EPO secretion and impacting physiological activities in the body.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Oncology

Resveratrol for cancer therapy: Challenges and future perspectives

Boxu Ren et al.

Summary: Despite its potential anticancer effects, resveratrol faces obstacles in clinical translation due to poor pharmacokinetics, low potency, and nephrotoxicity in certain patients. New strategies to enhance its bioavailability and develop more potent analogues are proposed to overcome these challenges and advance resveratrol in cancer therapy.

CANCER LETTERS (2021)

Article Oncology

ERK signaling controls productive HIF-1 binding to chromatin and cancer cell adaptation to hypoxia through HIF-1 alpha interaction with NPM1

Kreon Koukoulas et al.

Summary: ERK-mediated phosphorylation of HIF-1 alpha enhances its interaction with NPM1, which influences the transcriptional activation of HIF-1 target genes. NPM1 and HIF-1 co-regulate genes enriched in different cancer types, and their expression correlates with hypoxic tumor status and patient prognosis.

MOLECULAR ONCOLOGY (2021)

Review Urology & Nephrology

Dietary and circulating vitamin D and risk of renal cell carcinoma: a meta-analysis of observational studies

Jing Wu et al.

Summary: This meta-analysis found that higher circulating and dietary intake of vitamin D were associated with a reduced risk of renal cell carcinoma. Furthermore, subgroup analyses revealed significant gender differences in the results, with associations being stronger in studies involving women participants and case-control studies. Additional high-quality randomized controlled trials are needed to confirm these findings in the future.

INTERNATIONAL BRAZ J UROL (2021)

Review Genetics & Heredity

The Genomics and Genetics of Oxygen Homeostasis

Gregg L. Semenza

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 21, 2020 (2020)

Review Oncology

Wnt and Vitamin D at the Crossroads in Solid Cancer

Jose Manuel Gonzalez-Sancho et al.

CANCERS (2020)

Review Integrative & Complementary Medicine

Natural products as potent inhibitors of hypoxia-inducible factor-1α in cancer therapy

Zhong Jin-Cheng et al.

CHINESE JOURNAL OF NATURAL MEDICINES (2020)

Article Urology & Nephrology

Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience

Neil S. Sanghani et al.

ADVANCES IN CHRONIC KIDNEY DISEASE (2019)

Review Pharmacology & Pharmacy

Pharmacologic Targeting of Hypoxia-Inducible Factors

Gregg L. Semenza

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59 (2019)

Article Biochemistry & Molecular Biology

Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin

James A. Smythies et al.

EMBO REPORTS (2019)

Article Biochemistry & Molecular Biology

Vitamin D Switches BAF Complexes to Protect β Cells

Zong Wei et al.

Review Cell Biology

Advances in Hypoxia-Inducible Factor Biology

Hani Choudhry et al.

CELL METABOLISM (2018)

Article Biochemistry & Molecular Biology

On the role of classical and novel forms of vitamin D in melanoma progression and management

Andrzej T. Slominski et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2018)

Review Cell Biology

Eukaryotic core promoters and the functional basis of transcription initiation

Vanja Haberle et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Identification of a functional antioxidant response element at the HIF1A locus

Sarah E. Lacher et al.

REDOX BIOLOGY (2018)

Article Oncology

Gene expression profiles of CYP24A1 and CYP27B1 in malignant and normal breast tissues

Naghmeh Zhalehjoo et al.

MOLECULAR MEDICINE REPORTS (2017)

Review Biochemistry & Molecular Biology

Vitamin D as a Novel Regulator of Tumor Metabolism: Insights on Potential Mechanisms and Implications for Anti-Cancer Therapy

Mohamed A. Abu el Maaty et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Geriatrics & Gerontology

Vitamin D and Chronic Diseases

Hanmin Wang et al.

AGING AND DISEASE (2017)

Review Biochemistry & Molecular Biology

NF-κB and HIF crosstalk in immune responses

Laura D'Ignazio et al.

FEBS JOURNAL (2016)

Article Biochemistry & Molecular Biology

Epigenome-wide effects of vitamin D and their impact on the transcriptome of human monocytes involve CTCF

Sabine Seuter et al.

NUCLEIC ACIDS RESEARCH (2016)

Review Cell Biology

Extraskeletal actions of vitamin D

Daniel D. Bikle

MARROW 2016, VOL 1376 (2016)

Article Multidisciplinary Sciences

Targeting renal cell carcinoma with a HIF-2 antagonist

Wenfang Chen et al.

NATURE (2016)

Article Multidisciplinary Sciences

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

Hyejin Cho et al.

NATURE (2016)

Article Biochemistry & Molecular Biology

Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1

John W. Bullen et al.

SCIENCE SIGNALING (2016)

Article Multidisciplinary Sciences

Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth

Michael S. Nakazawa et al.

NATURE COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1

John W. Bullen et al.

SCIENCE SIGNALING (2016)

Review Cell Biology

Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and Transactivity

Thomas Kietzmann et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)

Article Physiology

PTH and Vitamin D

Syed Jalal Khundmiri et al.

COMPREHENSIVE PHYSIOLOGY (2016)

Review Oncology

Hypoxia-Inducible Factors: Master Regulators of Cancer Progression

Luana Schito et al.

TRENDS IN CANCER (2016)

Review Toxicology

NF-κB in cancer therapy

Feng Li et al.

ARCHIVES OF TOXICOLOGY (2015)

Article Cell Biology

Cezanne regulates E2F1-dependent HIF2α expressiond

Sonia Moniz et al.

JOURNAL OF CELL SCIENCE (2015)

Article Biochemistry & Molecular Biology

The 1,25D3-MARRS Receptor/PDIA3/ERp57 and Lifespan

Ilka Nemere et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2015)

Review Biochemistry & Molecular Biology

Membrane-mediated actions of 1,25-dihydroxy vitamin D3: A review of the roles of phospholipase A2 activating protein and Ca2+/calmodulin-dependent protein kinase II

Maryam Doroudi et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2015)

Review Biochemistry & Molecular Biology

CYP11A1 in skin: An alternative route to photoprotection by vitamin D compounds

Wannit Tongkao-on et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2015)

Review Plant Sciences

Vitamin D in cancer chemoprevention

Marco Giammanco et al.

PHARMACEUTICAL BIOLOGY (2015)

Article Oncology

Cytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways

Andrzej T. Slominski et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2014)

Review Biochemistry & Molecular Biology

Vitamin D Metabolism, Mechanism of Action, and Clinical Applications

Daniel D. Bikle

CHEMISTRY & BIOLOGY (2014)

Review Biochemistry & Molecular Biology

Transcriptional regulation by hypoxia inducible factors

Veronica L. Dengler et al.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2014)

Review Biochemistry & Molecular Biology

Thematic Review Series: Fat-Soluble Vitamins: Vitamin D Cytochrome P450-mediated metabolism of vitamin D

Glenville Jones et al.

JOURNAL OF LIPID RESEARCH (2014)

Review Biochemistry & Molecular Biology

Fundamentals of vitamin D hormone-regulated gene expression

J. Wesley Pike et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2014)

Review Biotechnology & Applied Microbiology

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

Holger K. Eltzschig et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Multidisciplinary Sciences

Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression

Maimon E. Hubbi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Oncology

The role of vitamin D in reducing cancer risk and progression

David Feldman et al.

NATURE REVIEWS CANCER (2014)

Article Oncology

The Anti-cancer Actions of Vitamin D

Kun-Chun Chiang et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2013)

Article Endocrinology & Metabolism

Molecular Mechanisms of Vitamin D Action

Mark R. Haussler et al.

CALCIFIED TISSUE INTERNATIONAL (2013)

Review Oncology

Vitamin D and breast cancer: Emerging concepts

Rajendra G. Mehta et al.

CANCER LETTERS (2013)

Article Cell Biology

Plasma membrane Pdia3 and VDR interact to elicit rapid responses to 1α,25(OH)2D3

Jiaxuan Chen et al.

CELLULAR SIGNALLING (2013)

Article Biochemistry & Molecular Biology

Vitamin D Receptor Inhibits Nuclear Factor κB Activation by Interacting with IκB Kinase β Protein

Yunzi Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Role of VDR in 1α,25-dihydroxyvitamin D3-dependent non-genomic activation of MAPKs, Src and Akt in skeletal muscle cells

Claudia Buitrago et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2013)

Review Biochemistry & Molecular Biology

Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses

Joanna Obacz et al.

MOLECULAR CANCER (2013)

Review Plant Sciences

Vitamin D in plants: a review of occurrence, analysis, and biosynthesis

Rie B. Japelt et al.

FRONTIERS IN PLANT SCIENCE (2013)

Article Endocrinology & Metabolism

Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies

Rong Ma et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2012)

Review Biochemistry & Molecular Biology

25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D

Glenville Jones et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2012)

Review Biochemistry & Molecular Biology

Vitamin D and cancer: a review of molecular mechanisms

James C. Fleet et al.

BIOCHEMICAL JOURNAL (2012)

Review Immunology

NF-κB and the link between inflammation and cancer

Joseph A. DiDonato et al.

IMMUNOLOGICAL REVIEWS (2012)

Article Medicine, General & Internal

Suppressive Effect of 19-nor-1α-25-Dihydroxyvitamin D2 on Gastric Cancer Cells and Peritoneal Metastasis Model

Mi Ra Park et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2012)

Article Oncology

Vitamin D in combination cancer treatment

Yingyu Ma et al.

Journal of Cancer (2012)

Review Pharmacology & Pharmacy

Mechanisms of the Anti-Cancer and Anti-Inflammatory Actions of Vitamin D

Aruna V. Krishnan et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 51, 2011 (2011)

Article Endocrinology & Metabolism

Vitamin D receptor (VDR)-mediated actions of 1α,25(OH)2vitarnin D3: Genomic and non-genomic mechanisms

Mark R. Haussler et al.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2011)

Review Biochemistry & Molecular Biology

Cytochromes P450 are essential players in the vitamin D signaling system

Inge Schuster

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2011)

Article Biochemistry & Molecular Biology

KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells

Fabio Pereira et al.

HUMAN MOLECULAR GENETICS (2011)

Article Biochemistry & Molecular Biology

TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1

H-O Jin et al.

ONCOGENE (2011)

Article Biochemistry & Molecular Biology

The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions

Ilias Mylonis et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Article Oncology

Serum 25(OH) Vitamin D and Risk of Breast Cancer: A Nested Case-Control Study from the French E3N Cohort

Pierre Engel et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2010)

Article Oncology

ApcMIN modulation of vitamin D secosteroid growth control

Haibo Xu et al.

CARCINOGENESIS (2010)

Article Biochemistry & Molecular Biology

Plk3 Functions as an Essential Component of the Hypoxia Regulatory Pathway by Direct Phosphorylation of HIF-1α

Dazhong Xu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Cell Biology

Casein kinase 1 regulates human hypoxia-inducible factor HIF-1

Alkmini Kalousi et al.

JOURNAL OF CELL SCIENCE (2010)

Review Nutrition & Dietetics

Vitamin D in health and disease: Current perspectives

Ran Zhang et al.

NUTRITION JOURNAL (2010)

Review Biochemistry & Molecular Biology

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

G. L. Semenza

ONCOGENE (2010)

Article Biochemistry & Molecular Biology

SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity

A. Barbachano et al.

ONCOGENE (2010)

Article Multidisciplinary Sciences

Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis

Peter Horak et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Gastroenterology & Hepatology

Hypoxia: A Link between Fibrogenesis, Angiogenesis, and Carcinogenesis in Liver Disease

Olivier Rosmorduc et al.

SEMINARS IN LIVER DISEASE (2010)

Article Oncology

Association between serum 25(OH) D and death from prostate cancer

S. Tretli et al.

BRITISH JOURNAL OF CANCER (2009)

Review Endocrinology & Metabolism

Nonclassic Actions of Vitamin D

Daniel Bikle

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)

Article Biochemistry & Molecular Biology

Regulation of hypoxia-inducible factor-1α by NF-κB

Patrick van Uden et al.

BIOCHEMICAL JOURNAL (2008)

Review Biochemistry & Molecular Biology

The role of hypoxia-inducible factors in tumorigenesis

E. B. Rankin et al.

CELL DEATH AND DIFFERENTIATION (2008)

Article Urology & Nephrology

Vitamin D in health and disease

Robert P. Heaney

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)

Review Cell Biology

Pathways connecting inflammation and cancer

Paola Allavena et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2008)

Review Endocrinology & Metabolism

Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice

Roger Bouillon et al.

ENDOCRINE REVIEWS (2008)

Article Biochemistry & Molecular Biology

Flavonoids induce HIF-1α but impair its nuclear accumulation and activity

Anastasia Triantafyllou et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Article Biochemistry & Molecular Biology

Differential Dependence of Hypoxia-inducible Factors 1α and 2α on mTORC1 and mTORC2

Alfredo Toschi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1α by MAPK

Ilias Mylonis et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Review Medicine, General & Internal

Vitamin D deficiency

Michael F. Holick

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Review Oncology

Defining the role of mTOR in cancer

David A. Guertin et al.

CANCER CELL (2007)

Article Gastroenterology & Hepatology

The canonical Wnt signalling pathway and its APC partner in colon cancer development

Jean Schneikert et al.

Article Biochemistry & Molecular Biology

The Vitamin D analogue TX 527 blocks NF-kappa B activation in peripheral blood mononuclear cells of patients with Crohn's disease

Maria Stio et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Vitamin D and cancer

Roger Bouillon et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1α

Ilias Mylonis et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Endocrinology & Metabolism

Increased NF-κB activity in fibroblasts lacking the vitamin D receptor

Jun Sun et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2006)

Article Biochemistry & Molecular Biology

Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-κB

Stilla Frede et al.

BIOCHEMICAL JOURNAL (2006)

Article Oncology

Prospective study of predictors of vitamin D status and cancer incidence and mortality in men

E Giovannucci et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2006)

Review Oncology

Promise of vitamin D analogues in the treatment of hyperproliferative conditions

S Masuda et al.

MOLECULAR CANCER THERAPEUTICS (2006)

Article Biochemistry & Molecular Biology

The molecular basis of vitamin D receptor and β-catenin crossregulation

S Shah et al.

MOLECULAR CELL (2006)

Article Biochemistry & Molecular Biology

The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism

A Slominski et al.

FEBS JOURNAL (2005)

Review Biochemistry & Molecular Biology

Negative and positive regulation of HIF-1:: A complex network

JI Bárdos et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2005)

Review Genetics & Heredity

Genetics and biology of vitamin D receptor polymorphisms

AG Uitterlinden et al.

Article Oncology

High-dose calcitriol and carboplatin in metastatic androgen-independent prostate cancer

TM Beer et al.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2004)

Article Biochemistry & Molecular Biology

Molecular activity of 1,25-dihydroxyvitamin D3 in primary cultures of human prostatic epithelial cells revealed by cDNA microarray analysis

DM Peehl et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Identification and characterization of 1,25D3-membrane-associated rapid response, steroid (1,25D3-MARRS) binding protein

K Nemere et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2004)

Review Biochemistry & Molecular Biology

The pleiotropic actions of vitamin D

R Lin et al.

BIOESSAYS (2004)

Review Biotechnology & Applied Microbiology

HIF-1 as a target for drug development

A Giaccia et al.

NATURE REVIEWS DRUG DISCOVERY (2003)

Article Biochemistry & Molecular Biology

The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine

K Gradin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Review Oncology

NF-κB in cancer:: From innocent bystander to major culprit

M Karin et al.

NATURE REVIEWS CANCER (2002)

Article Multidisciplinary Sciences

Parathyroid hormone regulates 25-hydroxyvitamin D3-24-hydroxylase mRNA by altering its stability

C Zierold et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

ERK activation upon hypoxia: involvement in HIF-1 activation

E Minet et al.

FEBS LETTERS (2000)