☆ 4.6 Article

Clinical Significance of Tumor-Infiltrating Conventional and Plasmacytoid Dendritic Cells in Pancreatic Ductal Adenocarcinoma

CANCERS (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Oncology

Tumor Microenvironment Immune Response in Pancreatic Ductal Adenocarcinoma Patients Treated With Neoadjuvant Therapy

Theodoros Michelakos et al.

Summary: This study evaluated the immune response induced by neoadjuvant therapy in PDAC patients. The findings suggest that neoadjuvant FOLFIRINOX may lead to immunologically relevant changes in the tumor microenvironment, reducing HLAA defects, increasing CD8(+) cell density, and decreasing T regulatory cell and M2 macrophage density.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2021)

添加到收藏夹

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

添加到收藏夹

Article Oncology

Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma

Sachie Kiryu et al.

Summary: The density of TILs, PD-1+ cells, and Foxp3+ T cells in the TME of PDAC patients is associated with overall survival and disease-free survival. High density of TILs or PD-1+ cells is linked to better prognosis, while high levels of Foxp3+ T cells are associated with worse outcomes.

BMC CANCER (2021)

添加到收藏夹

Article Oncology

Plasmacytoid dendritic cells recruited by HIF-1α/eADO/ADORA1 signaling induce immunosuppression in hepatocellular carcinoma

Li Pang et al.

Summary: This study found that the accumulation of pDCs in HCC patients is correlated with poor prognosis. Hypoxia-induced eADO enhances pDC recruitment into tumors via ADORA1, affecting the function of immune cells.

CANCER LETTERS (2021)

添加到收藏夹

Article Oncology

Neoadjuvant FOLFIRINOX Therapy Is Associated with Increased Effector T Cells and Reduced Suppressor Cells in Patients with Pancreatic Cancer

Hui Peng et al.

Summary: The study demonstrates that FOLFIRINOX has a significant impact on the immune system of patients with PDAC, by enhancing effector T cells and downregulating suppressor cells. This suggests that neoadjuvant therapy with FOLFIRINOX may improve immune therapy and clinical outcomes in patients with PDAC.

CLINICAL CANCER RESEARCH (2021)

添加到收藏夹

Review Oncology

The Role of Stellate Cells in Pancreatic Ductal Adenocarcinoma: Targeting Perspectives

Yang Wu et al.

Summary: PDAC progression is influenced by PSCs, which through interactions with PCCs and other stroma cells, establish a tumor microenvironment that promotes tumor growth, metastasis, and chemoresistance. Targeting stroma has emerged as a promising strategy for PDAC therapy, with several novel strategies proposed to intervene in this complex crosstalk.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Review Cell Biology

Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming

Sen Yang et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy that can only be cured by surgery in its early stages, but recurrence remains a high possibility. Tumor-associated macrophages (TAMs) play a crucial role in PDAC development, promoting tumor behaviors such as tumorigenesis and metastasis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Review Immunology

The Natural Killer-Dendritic Cell Immune Axis in Anti-Cancer Immunity and Immunotherapy

Erin E. Peterson et al.

Summary: The intercellular cross-talk between NK cells and cDC1s plays a crucial role in immune responses to cancer, impacting the efficacy of certain immunotherapies and overall survival rates for patients.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Deciphering the Prognostic Implications of the Components and Signatures in the Immune Microenvironment of Pancreatic Ductal Adenocarcinoma

Rong Tang et al.

Summary: Neutrophils are associated with worse prognosis for PDAC, while CD8+ T cells, CD4+ T cells, and B cells are related to prolonged overall survival with marginal statistical significance. Furthermore, the signatures of CD8+ T cells, NKT cells, and HSC-like signature predict prolonged OS in PDAC, especially in the presence of targets for pyroptosis and ferroptosis induction.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Immunology

The Role of Plasmacytoid Dendritic Cells in Cancers

Binhui Zhou et al.

Summary: Plasmacytoid dendritic cells (pDCs) are a special subtype of dendritic cells that produce massive amounts of type I interferon (IFN-I) and play a pivotal role in antiviral immunity. However, in many types of cancer, tumor-infiltrating pDCs do not respond to Toll-like receptor (TLR) stimulation, leading to reduced IFN-alpha production and promoting tumor growth.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Oncology

Tumor-infiltrating plasmacytoid dendritic cells are associated with survival in human colon cancer

Maximilian Kiessler et al.

Summary: The study found that higher densities of tumor-infiltrating pDCs are associated with lower UICC staging, increased progression-free and overall survival in colon cancer patients. A lower number of colon cancer-infiltrating pDCs was independently linked to worse prognosis, while the colocalization of activated pDCs and T cells in tumor stroma and within TLS may contribute to the correlation between higher pDC densities and better prognosis.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

添加到收藏夹

Article Oncology

LAG-3-Expressing Tumor-Infiltrating T Cells Are Associated with Reduced Disease-Free Survival in Pancreatic Cancer

Lena Seifert et al.

Summary: In this study, the expression pattern of co-stimulatory and inhibitory receptors by tumor-infiltrating T cells in pancreatic ductal adenocarcinoma (PDAC) was investigated. The findings suggest that T cells are enriched in the stromal area of PDAC, with CD8(+) and Th1-polarized CD4(+) T cell infiltration associated with prolonged survival. Additionally, LAG-3 expression by PDAC-infiltrating T cells was correlated with reduced disease-free survival, highlighting the potential of LAG-3 as a prognostic marker and a target for immunotherapeutic strategies.

CANCERS (2021)

添加到收藏夹

Review Oncology

Non-Invasive Biomarkers for Earlier Detection of Pancreatic Cancer-A Comprehensive Review

Greta Brezgyte et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal disease, with challenges in accurately detecting it at an early stage using current biomarkers. This study systematically reviewed the literature on non-invasive biomarkers for early PDAC detection over a 10-year period, identifying promising biomarkers but highlighting the complexity in translating them to clinical use.

CANCERS (2021)

添加到收藏夹

Review Oncology

The Current Treatment Paradigm for Pancreatic Ductal Adenocarcinoma and Barriers to Therapeutic Efficacy

Daniel R. Principe et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) has poor prognosis, mainly due to late diagnosis, multi-drug resistance, and associated toxicities of chemotherapy. Current treatments are not very effective, highlighting the need to improve understanding of factors limiting efficacy in order to enhance patient survival and quality of life.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Article Oncology

Spatial distribution of B cells and lymphocyte clusters as a predictor of triple-negative breast cancer outcome

Juliana C. Wortman et al.

Summary: The study highlights the importance of spatial distribution of B cells and LCs within tumors for prognosis, showing that in good outcome tumors, B cells and LCs are more abundant and more spatially dispersed.

NPJ BREAST CANCER (2021)

添加到收藏夹

Article Immunology

Type 1 conventional dendritic cells and interferons are required for spontaneous CD4+ and CD8+ T-cell protective responses to breast cancer

Raphael Mattiuz et al.

Summary: Interferons and cDC1 are critical for breast cancer immunosurveillance. IFN-gamma plays a prominent role over IFN-I in licensing cDC1 for efficient T-cell activation. High intratumor expression of genes specific to cDC1, CTLs, CD4(+) T cells, or IFN responses is associated with a better prognosis in breast cancer patients.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Chemotherapy-induced recruitment of myeloid-derived suppressor cells abrogates efficacy of immune checkpoint blockade

Tsz Tung Kwong et al.

Summary: The study demonstrates that 5-FU can induce the accumulation of immunosuppressive MDSCs, impairing the response to PD-L1 blockade in HCC. Some chemotherapies may impair the anti-tumor efficacy of immunotherapy, warranting further investigation.

JHEP REPORTS (2021)

添加到收藏夹

Article Oncology

Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells

Carmen Mota Reyes et al.

CLINICAL CANCER RESEARCH (2020)

添加到收藏夹

Review Immunology

Tumor Immunology and Tumor Evolution: Intertwined Histories

Jerome Galon et al.

IMMUNITY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Upregulation of CD20 Positive B-Cells and B-Cell Aggregates in the Tumor Infiltration Zone is Associated with Better Survival of Patients with Pancreatic Ductal Adenocarcinoma

Maximilian Brunner et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Oncology

Current and emerging therapies for patients with advanced pancreatic ductal adenocarcinoma: a bright future

Eric S Christenson et al.

LANCET ONCOLOGY (2020)

添加到收藏夹

Article Oncology

Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

Samarth Hegde et al.

CANCER CELL (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

New Treatment Strategies for Metastatic Pancreatic Ductal Adenocarcinoma

Ritu Raj Singh et al.

DRUGS (2020)

添加到收藏夹

Review Oncology

The tumour microenvironment in pancreatic cancer - clinical challenges and opportunities

Won Jin Ho et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

添加到收藏夹

Article Immunology

IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer

Margaux Hubert et al.

SCIENCE IMMUNOLOGY (2020)

添加到收藏夹

Article Oncology

Quantitative and qualitative impairments in dendritic cell subsets of patients with ovarian or prostate cancer

Beatris Mastelic-Gavillet et al.

EUROPEAN JOURNAL OF CANCER (2020)

添加到收藏夹

Review Immunology

The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

Yuanyuan Zhang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Functional Role of Dendritic Cell Subsets in Cancer Progression and Clinical Implications

Annalisa Del Prete et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Crosstalk between Tumor and Stromal Cells in Pancreatic Ductal Adenocarcinoma

Nadine Sperb et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Multidisciplinary Sciences

The landscape of immune cell infiltration and its clinical implications of pancreatic ductal adenocarcinoma

Caiming Xu et al.

JOURNAL OF ADVANCED RESEARCH (2020)

添加到收藏夹

Article Immunology

Type 1 conventional dendritic cells are systemically dysregulated early in pancreatic carcinogenesis

Jeffrey H. Lin et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

添加到收藏夹

Article Oncology

PD-1 Expression by Lymph Node and Intratumoral Regulatory T Cells Is Associated with Lymph Node Metastasis in Pancreatic Cancer

Adrian M. Seifert et al.

CANCERS (2020)

添加到收藏夹

Article Immunology

BDCA1+ cDC2s, BDCA2+ pDCs and BDCA3+ cDC1s reveal distinct pathophysiologic features and impact on clinical outcomes in melanoma patients

Eleonora Sosa Cuevas et al.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2020)

添加到收藏夹

Review Oncology

The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy

Daniela Bruni et al.

NATURE REVIEWS CANCER (2020)

添加到收藏夹

Review Immunology

Dendritic cells in cancer immunology and immunotherapy

Stefanie K. Wculek et al.

NATURE REVIEWS IMMUNOLOGY (2020)

添加到收藏夹

Review Oncology

Cancer-Associated Fibroblasts' Functional Heterogeneity in Pancreatic Ductal Adenocarcinoma

Mohammad Awaji et al.

CANCERS (2019)

添加到收藏夹

Review Oncology

Prognostic value of tumor-associated macrophages in pancreatic cancer: a meta-analysis

Min Yu et al.

CANCER MANAGEMENT AND RESEARCH (2019)

添加到收藏夹

Review Immunology

Cytotoxic Chemotherapy as an Immune Stimulus: A Molecular Perspective on Turning Up the Immunological Heat on Cancer

James W. Opzoomer et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Immunology

Human Dendritic Cell Subsets, Ontogeny, and Impact on HIV Infection

Jake William Rhodes et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

Broadening the Impact of Immunotherapy to Pancreatic Cancer: Challenges and Opportunities

Vinod P. Balachandran et al.

GASTROENTEROLOGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

Jan P. Boettcher et al.

CELL (2018)

添加到收藏夹

Review Immunology

Human dendritic cell subsets: an update

Matthew Collin et al.

IMMUNOLOGY (2018)

添加到收藏夹

Article Immunology

Adjustment of dendritic cells to the breast-cancer microenvironment is subset specific

Paula Michea et al.

NATURE IMMUNOLOGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Understanding the tumor immune microenvironment (TIME) for effective therapy

Mikhail Binnewies et al.

NATURE MEDICINE (2018)

添加到收藏夹

Article Pathology

High immune cell score predicts improved survival in pancreatic cancer

Kyosti Tahkola et al.

VIRCHOWS ARCHIV (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance

Melissa A. Meyer et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Multiplex immunohistochemistry accurately defines the immune context of metastatic melanoma

H. Halse et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Gastroenterology & Hepatology

Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma

Ujjwal Mukund Mahajan et al.

GASTROENTEROLOGY (2018)

添加到收藏夹

Article Oncology

Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients

Iva Truxova et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

添加到收藏夹

Review Oncology

The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity

Jan P. Boettcher et al.

TRENDS IN CANCER (2018)

添加到收藏夹

Review Oncology

The immune contexture in cancer prognosis and treatment

Wolf H. Fridman et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer

Julienne L. Carstens et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Review Oncology

Functions of pancreatic stellate cell-derived soluble factors in the microenvironment of pancreatic ductal carcinoma

Qi Wu et al.

ONCOTARGET (2017)

添加到收藏夹

Article Cell Biology

Crosstalk between Regulatory T Cells and Tumor-Associated Dendritic Cells Negates Anti-tumor Immunity in Pancreatic Cancer

Jung-Eun Jang et al.

CELL REPORTS (2017)

添加到收藏夹

Article Oncology

An Immunosuppressive Dendritic Cell Subset Accumulates at Secondary Sites and Promotes Metastasis in Pancreatic Cancer

Justin A. Kenkel et al.

CANCER RESEARCH (2017)

添加到收藏夹

Article Oncology

Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma

Giovanni Francesco Castino et al.

ONCOIMMUNOLOGY (2016)

添加到收藏夹

Review Oncology

Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

Lorenzo Galluzzi et al.

CANCER CELL (2015)

添加到收藏夹

Article Oncology

Adverse Immunoregulatory Effects of 5FU and CPT11 Chemotherapy on Myeloid-Derived Suppressor Cells and Colorectal Cancer Outcomes

Julia Kanterman et al.

CANCER RESEARCH (2014)

添加到收藏夹

Article Oncology

CD1c+ and CD303+ dendritic cells in peripheral blood, lymph nodes and tumor tissue of patients with non-small cell lung cancer

Jacek Tabarkiewicz et al.

ONCOLOGY REPORTS (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Pancreatic Ductal Adenocarcinoma Contains an Effector and Regulatory Immune Cell Infiltrate that Is Altered by Multimodal Neoadjuvant Treatment

Kendall C. Shibuya et al.

PLOS ONE (2014)

添加到收藏夹

Article Oncology

IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival

Serena Lunardi et al.

ONCOTARGET (2014)

添加到收藏夹

Article Oncology

Plasmacytoid Dendritic Cells Support Melanoma Progression by Promoting Th2 and Regulatory Immunity through OX40L and ICOSL

Caroline Aspord et al.

CANCER IMMUNOLOGY RESEARCH (2013)

添加到收藏夹

Article Immunology

TRAIL+ Human Plasmacytoid Dendritic Cells Kill Tumor Cells In Vitro: Mechanisms of Imiquimod- and IFN-α-Mediated Antitumor Reactivity

Madeleine L. Kalb et al.

JOURNAL OF IMMUNOLOGY (2012)

添加到收藏夹

Article Surgery

Circulating Myeloid Dendritic Cells as Prognostic Factors in Patients with Pancreatic Cancer Who Have Undergone Surgical Resection

Tomohisa Yamamoto et al.

JOURNAL OF SURGICAL RESEARCH (2012)

添加到收藏夹

Editorial Material Oncology

Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis

Sana Intidhar Labidi-Galy et al.

ONCOIMMUNOLOGY (2012)

添加到收藏夹

Article Hematology

Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion

Bernd Jahrsdoerfer et al.

BLOOD (2010)

添加到收藏夹

Article Oncology

Pancreatic adenocarcinoma exerts systemic effects on the peripheral blood myeloid and plasmacytoid dendritic cells: an indicator of disease severity?

Vegard Tjomsland et al.

BMC CANCER (2010)

添加到收藏夹

Article Oncology

Prognostic effect of epithelial and stromal lymphocyte infiltration in non-small cell lung cancer

Khalid I. Al-Shibli et al.

CLINICAL CANCER RESEARCH (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

Calreticulin exposure dictates the immunogenicity of cancer cell death

Michel Obeid et al.

NATURE MEDICINE (2007)

添加到收藏夹

Article Oncology

Dendritic cell infiltration and prognosis of early stage breast cancer

I Treilleux et al.

CLINICAL CANCER RESEARCH (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.