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Cancer Stem Cells (CSCs), Circulating Tumor Cells (CTCs) and Their Interplay with Cancer Associated Fibroblasts (CAFs): A New World of Targets and Treatments

CANCERS (2022)

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Article Cell & Tissue Engineering

The Influence of Cancer Stem Cells on the Risk of Relapse in Adenocarcinoma and Squamous Cell Carcinoma of the Lung: A Prospective Cohort Study

Valentina Masciale et al.

Summary: This study assessed the relationship between cancer stem cells (CSCs) and relapse rates in patients with adenocarcinoma (ADL) and squamous cell carcinoma of the lung (SCCL). The results showed no association between CSCs and relapse rates in early-stage patients, but a positive correlation was observed in locally advanced patients.

STEM CELLS TRANSLATIONAL MEDICINE (2022)

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Article Biotechnology & Applied Microbiology

LncRNA SNHG12 in extracellular vesicles derived from carcinoma-associated fibroblasts promotes cisplatin resistance in non-small cell lung cancer cells

Deli Tan et al.

Summary: This study aimed to investigate the regulatory effect of SNHG12 carried by CAFs-EVs on DDP resistance in NSCLC cells. The results showed that SNHG12 carried by CAFs-EVs promoted DDP resistance in NSCLC cells by enhancing RNA stability and XIAP transcription through binding to HuR.

BIOENGINEERED (2022)

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Review Oncology

Dissecting Tumor Growth: The Role of Cancer Stem Cells in Drug Resistance and Recurrence

Beatrice Aramini et al.

Summary: Cancer stem cells (CSCs) play a crucial role in tumor initiation, progression, and metastasis. They share characteristics with normal stem cells, such as self-renewal and differentiation potential. CSCs establish their niche, a unique microenvironment within the tissue, which sustains their functions. The interactions between CSCs and their niches regulate their self-renewal and tumorigenesis. Understanding the primary mechanisms involved in CSC tumorigenesis is essential for developing targeted therapies. Moreover, CSCs' resistance to standard treatments and their phenotypic plasticity pose challenges in cancer therapeutics.

CANCERS (2022)

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Article Chemistry, Medicinal

Relevance of Circulating Tumor Cells as Predictive Markers for Cancer Incidence and Relapse

Chaithanya Chelakkot et al.

Summary: Shedding cancer cells from the primary site or bone marrow into the circulatory system and their subsequent formation of secondary metastatic lesions is a key feature of invasive cancers. Circulating tumor cells (CTCs), found either as single cells or clusters, carry valuable information and have the potential to predict cancer prognosis, progression, and guide tailored therapies.

PHARMACEUTICALS (2022)

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Article Biology

Identification, Culture and Targeting of Cancer Stem Cells

Alejandro Herreros-Pomares

Summary: Chemoresistance, tumor progression, and metastasis are common features in cancer that are associated with cancer stem cells (CSCs), which are promising targets for future cancer therapy. However, CSCs still remain largely unknown. Further research is needed to explore the deregulation of pathways in non-tumorigenic stem cells (SCs) and identify new therapeutic targets. Additionally, the search for specific CSC markers is still under development.

LIFE-BASEL (2022)

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Article Oncology

Sulfonylurea receptor 1-expressing cancer cells induce cancer-associated fibroblasts to promote non-small cell lung cancer progression

Hongling Chen et al.

Summary: SUR1-expressing cancer cells induce the transformation of normal fibroblasts into cancer-associated fibroblasts (CAFs) in the tumor microenvironment and promote the progression of non-small cell lung carcinoma (NSCLC) by transferring less exosomal let-7a-5p. Glibenclamide targeting SUR1 is a promising anti-cancer drug, and the level of plasma exosomal let-7a-5p serves as a potential diagnostic biomarker for NSCLC patients.

CANCER LETTERS (2022)

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Review Oncology

The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment

Asieh Emami Nejad et al.

Summary: Tumor hypoxia, caused by rapid tumor growth and abnormal blood vessel formation, can activate angiogenesis, increase tumor survival, suppress immunity, and requires management through mechanisms such as altering gene expression. The potential use of cancer stem cells in tumor treatment has been highlighted.

CANCER CELL INTERNATIONAL (2021)

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Article Biology

In silico methods and tools for drug discovery

Bilal Shaker et al.

Summary: Traditional drug discovery strategies have long development times and high costs; recently, computational methods have attracted attention for their potential to accelerate drug discovery and successfully develop new drugs; this review introduces computational drug discovery strategies, tools, and successful examples.

COMPUTERS IN BIOLOGY AND MEDICINE (2021)

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Review Oncology

Cancer Stem Cells-Key Players in Tumor Relapse

Monica Marzagalli et al.

Summary: Cancer stem cells (CSCs) are a subset of cancer cells with tumor-initiating and self-renewal capacity, as well as high adaptive abilities, contributing to treatment failure and tumor progression/relapse. Understanding the molecular mechanisms associated with stemness-driven resistance is crucial for developing more effective drugs and durable responses. Explored mechanisms by CSCs to overcome different therapeutic strategies highlight their plasticity as an insidious trait responsible for their adaptation/escape, with novel CSC-specific approaches showing promising preclinical and clinical applications.

CANCERS (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Biochemistry & Molecular Biology

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Xiaoqi Mao et al.

Summary: CAFs, as a crucial component of TME, play significant roles in promoting tumor growth, invasion, and metastasis. The interaction between CAFs and tumor cells, as well as immune cells in TIME, is critical for tumor progression.

MOLECULAR CANCER (2021)

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Cancer stem cells and macrophages: molecular connections and future perspectives against cancer

Beatrice Aramini et al.

Oncotarget (2021)

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Review Genetics & Heredity

Somatic mutations provide important and unique insights into the biology of complex diseases

Sigurgeir Olafsson et al.

Summary: The evolution of somatic cells in the body can lead to both cancer and non-neoplastic diseases. Expanding research from healthy tissues to diseased conditions could provide insights into the causes and consequences of common complex diseases by studying the interaction between somatic mutations and non-neoplastic diseases.

TRENDS IN GENETICS (2021)

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Review Oncology

Targeting Tumor-Associated Macrophages in Cancer Immunotherapy

Amy J. Petty et al.

Summary: Tumor-associated macrophages (TAMs) are the most abundant leukocyte population in most solid tumors and play a significant role in promoting tumor growth and metastasis. They are influenced by the tumor microenvironment and interact with other cell populations within the tumor milieu, leading to poor outcomes in multiple tumors. Therapeutic strategies targeting TAMs in cancer treatments focus on reducing monocyte recruitment, depleting or reprogramming TAMs, and targeting inhibitory molecules to enhance TAM-mediated phagocytosis.

CANCERS (2021)

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Review Oncology

Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications

Michela Saviana et al.

Summary: Extracellular vesicles serve as crucial mediators for cell communication through bioactive molecules, offering valuable insights into tumor biology. They play roles not only in physiological and pathological processes, but also as potential tumor biomarkers.

CANCERS (2021)

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Review Pharmacology & Pharmacy

Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design

Zdenek Kejik et al.

Summary: Designing optimal adjuvant therapy is crucial in treating non-small-cell lung carcinoma. Standard methods may not be effective in cases with high level of CTCs, thus alternative therapeutic strategies like low-toxicity natural agents may be considered when standard methods fail. This review discusses NSCLC therapy strategies and potential options for treatment beyond standard methods.

PHARMACEUTICS (2021)

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Review Engineering, Biomedical

Small extracellular vesicles in cancer

Komal Abhange et al.

Summary: Extracellular vesicles (EVs) are lipid-bilayer enclosed vesicles released from cells, carrying various molecules and playing crucial roles in tumors. EVs exhibit expression patterns similar to parental cells, aiding in early cancer diagnosis and treatment monitoring. In addition to research and diagnostics, EVs are utilized as drug delivery nanocarriers and therapeutic targets.

BIOACTIVE MATERIALS (2021)

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Article Biology

Cancer-Associated Fibroblasts Regulate the Plasticity of Breast Cancer Stemness through the Production of Leukemia Inhibitory Factor

Nazanin Vaziri et al.

Summary: In this study, a coculture system of breast cancer cells and fibroblasts was used to investigate the impact of leukemia inhibitory factor (LIF) on breast cancer stem cell properties. The results showed that CAF cells in the cocultivation system produced LIF, which promoted stemness by activating the LIFR signaling pathway in breast cancer cells. This suggests that targeting LIF/LIFR signaling could be an effective therapeutic strategy for breast cancer and preventing tumor recurrence.

LIFE-BASEL (2021)

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Article Medicine, General & Internal

Aneuploid Circulating Tumor Cells as a Predictor of Response to Neoadjuvant Chemotherapy in Non-Small Cell Lung Cancer

Miao Huang et al.

Summary: The study revealed the correlation between changes in CTC numbers and the efficacy of NAC in NSCLC patients. Aneuploid CTCs were associated with both radiological and pathological responses, serving as a surrogate marker for disease monitoring in NSCLC.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2021)

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Article Multidisciplinary Sciences

Real-world outcomes versus clinical trial results of immunotherapy in stage IV non-small cell lung cancer (NSCLC) in the Netherlands

Christine M. Cramer-van der Welle et al.

Summary: This study assesses the clinical outcomes of immunotherapy in real-world settings versus clinical trials for NSCLC patients. The findings suggest that there is no efficacy-effectiveness gap for PFS from immunotherapy, but there is a gap in OS for 1L pembrolizumab. Fewer patients proceeding to subsequent lines of treatment in real-world may partly explain this difference.

SCIENTIFIC REPORTS (2021)

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Review Pharmacology & Pharmacy

The Role of Tumor Inflammatory Microenvironment in Lung Cancer

Zhaofeng Tan et al.

Summary: Lung cancer is the most common and fatal malignant tumor globally, with inflammation playing a crucial role in its occurrence and development. Inflammatory cells and factors in the tumor microenvironment promote lung cancer by activating inflammatory pathways and mechanisms like immune escape, angiogenesis, and apoptosis. Understanding the relationship between inflammation and lung cancer through the tumor microenvironment can lead to the discovery of new therapeutic targets for the disease.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Oncology

New Perspectives in Different Gene Expression Profiles for Early and Locally Advanced Non-Small Cell Lung Cancer Stem Cells

Valentina Masciale et al.

Summary: This study aimed to evaluate whether cancer stem cells (CSC) in patients with early and locally advanced stages of non-small cell lung cancer (NSCLC) display overexpression of a pool of genes associated with recurrence. The results showed that 16 (51.6%) out of 31 recurrence-related genes were significantly overexpressed in ALDH(high) cells in early-stage patients.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

Cancer-Associated Fibroblasts and Tumor-Associated Macrophages in Cancer and Cancer Immunotherapy

Hans Raskov et al.

Summary: Understanding the tumor microenvironment is crucial for innovating new therapeutic approaches in cancer treatment, especially the cell-cell communication within the TME. Cancer-associated fibroblasts (CAF) and tumor-associated macrophages (TAM) are major cell populations in solid tumors with potential as therapeutic targets. Further research and innovation are needed to fully comprehend the roles of CAF and TAM in cancer and improve targeted treatment strategies.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Original Research Clinical outcomes of non-small cell lung cancer patients with leptomeningeal metastases after immune checkpoint inhibitor treatments

Mei-Mei Zheng et al.

Summary: This study aimed to investigate the effect of immune checkpoint inhibitors (ICIs) on the survival of non-small cell lung cancer (NSCLC) patients with leptomeningeal metastases (LM). The results showed that NSCLC patients receiving ICIs treatment after LM diagnosis achieved certain efficacy, especially for patients with good ECOG-PS scores.

EUROPEAN JOURNAL OF CANCER (2021)

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Review Immunology

Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance

Khalil Khalaf et al.

Summary: The tumor microenvironment (TME) is a complex and dynamic tissue containing various components such as blood supply, immune cells, and extracellular matrix, which together create an environment conducive to tumor cell growth and proliferation. Cellular crosstalk, cell-to-ECM communication, exosomes, and specific metabolic patterns play crucial roles in immune evasion and therapy resistance in the TME. In addition, characteristics like hypoxia, metabolic abnormalities, and mechanical forces further contribute to treatment resistance.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

Subpopulations of Circulating Cells with Morphological Features of Malignancy Are Preoperatively Detected and Have Differential Prognostic Significance in Non-Small Cell Lung Cancer

Emanuela Fina et al.

Summary: Lung cancer is the leading cause of cancer-related deaths globally. This study focused on analyzing circulating tumor cells in patients with non-small cell lung cancer to develop a blood-based diagnostic test and identify those at risk of disease recurrence. Detection of circulating tumor cells was found to predict the risk of disease recurrence, highlighting the potential of cell-based tests for screening programs.

CANCERS (2021)

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Review Cell & Tissue Engineering

Alternative models of cancer stem cells: The stemness phenotype model, 10 years later

Vivek Kaushik et al.

Summary: The traditional cancer stem cell theory suggests the existence of a rare but constant subpopulation of CSCs, but this hierarchical model has been challenged by experimental data. The SPM proposes a non-hierarchical model of cancer biology, highlighting the high plasticity of cancer cells in terms of stemness and the ability for CSCs and non-CSCs to interconvert. Experimental evidence in the past decade supports the extreme plasticity of cancer cells, allowing for interconversion into cells with different stemness phenotypes.

WORLD JOURNAL OF STEM CELLS (2021)

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Review Biochemistry & Molecular Biology

Circulating tumor cells: biology and clinical significance

Danfeng Lin et al.

Summary: CTCs, tumor cells that have sloughed off the primary tumor and circulate in the blood, have potential for identifying targets against cancer metastasis. Detecting these rare CTCs in the massive pool of blood cells is challenging, but emerging detection technologies have deepened our understanding of their biology and clinical applications. Molecular markers, such as epithelial cell adhesion molecule, play a key role in CTC detection, with properties like epithelial-to-mesenchymal transition and stemness indicating increased metastatic capacity.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Medicine, General & Internal

Breast cancer recurrence prediction with ensemble methods and cost-sensitive learning

Pei-Tse Yang et al.

Summary: This study proposed a prediction model for breast cancer recurrence based on clinical features. By processing data, selecting features, resampling, and building classifiers, the model achieved high accuracy and sensitivity, providing a supporting tool for early intervention and reducing cancer mortality.

OPEN MEDICINE (2021)

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Review Oncology

The Role of the Microenvironment and Immune System in Regulating Stem Cell Fate in Cancer

L. Paige Ferguson et al.

Summary: Despite increased knowledge of the intrinsic signals involved in cancer progression, effective clinical management of cancer remains challenging. Drug resistance and relapse, primarily driven by the exploitation of stem cell programs by aggressive cancer cell subpopulations, are major barriers in cancer care. Understanding the niche and signals that sustain cancer stem cells may lead to new strategies in targeting them by disrupting the microenvironmental support.

TRENDS IN CANCER (2021)

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Review Biochemistry & Molecular Biology

The key roles of cancer stem cell-derived extracellular vesicles

Chaoyue Su et al.

Summary: Cancer stem cells (CSCs)-derived extracellular vesicles (EVs) play a significant role in tumor progression, including promoting tumor resistance, metastasis, angiogenesis, as well as maintaining stemness phenotype and tumor immunosuppression microenvironment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Biochemistry & Molecular Biology

Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents

He-Ming Zhou et al.

Summary: Understanding the key characteristics and resistance mechanisms of CSCs may improve patient outcomes and reduce relapse. Targeting the mechanisms and pathways of CSCs described in this review could lead to further drug discovery and therapy development.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Gastroenterology & Hepatology

Recent developments in cancer research: Expectations for a new remedy

Koji Ando et al.

Summary: Cancer research has made significant progress, with new discoveries in immune checkpoint inhibition mechanisms leading to the development of immune checkpoint inhibitors. Areas such as exosomes, microbiome, immunotherapy, and organoids are emerging as important fields in cancer research, potentially yielding new treatments in the future.

ANNALS OF GASTROENTEROLOGICAL SURGERY (2021)

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Review Oncology

A snapshot of the PD-1/PD-L1 pathway

Chinmoy Ghosh et al.

Summary: Immune checkpoint blockade is a promising strategy for treating cancer by reactivating anti-tumor immunity, but the response rates and resistance towards current anti-PD-1/PD-L1 therapies remain challenges. New perspectives are needed to overcome these hurdles for successful cancer treatment.

JOURNAL OF CANCER (2021)

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Review Genetics & Heredity

Clinical implications of intratumor heterogeneity: challenges and opportunities

Santiago Ramon y Cajal et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2020)

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Article Multidisciplinary Sciences

Estimating growth patterns and driver effects in tumor evolution from individual samples

Leonidas Salichos et al.

NATURE COMMUNICATIONS (2020)

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Review Cell Biology

Tumor microenvironment complexity and therapeutic implications at a glance

Roghayyeh Baghba et al.

CELL COMMUNICATION AND SIGNALING (2020)

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Review Cell Biology

The future of cancer immunotherapy: microenvironment-targeting combinations

Yonina R. Murciano-Goroff et al.

CELL RESEARCH (2020)

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Article Cell Biology

Lung CSC-derived exosomal miR-210-3p contributes to a pro-metastatic phenotype in lung cancer by targeting FGFRL1

Wang Li et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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CD44+/EPCAM+ cells detect a subpopulation of ALDHhigh cells in human non-small cell lung cancer: A chance for targeting cancer stem cells?

Valentina Masciale et al.

Oncotarget (2020)

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Article Oncology

PD-L1 expression and T cells infiltration in patients with uncommon EGFR-mutant non-small cell lung cancer and the response to immunotherapy

Kaiyan Chen et al.

LUNG CANCER (2020)

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Review Oncology

Pancreatic Cancer Associated Fibroblasts (CAF): Under-Explored Target for Pancreatic Cancer Treatment

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CANCERS (2020)

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Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

Ayuko Hoshino et al.

CELL (2020)

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Review Immunology

The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

Yuanyuan Zhang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Cancer Stem Cells-Origins and Biomarkers: Perspectives for Targeted Personalized Therapies

Lia Walcher et al.

FRONTIERS IN IMMUNOLOGY (2020)

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EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis

Anthony Genna et al.

CANCERS (2020)

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Review Biochemistry & Molecular Biology

New Insights Into the Role of Phenotypic Plasticity and EMT in Driving Cancer Progression

Sugandha Bhatia et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

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Multi-Institutional Prospective Validation of Prognostic mRNA Signatures in Early Stage Squamous Lung Cancer (Alliance)

Raphael Bueno et al.

JOURNAL OF THORACIC ONCOLOGY (2020)

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Review Oncology

Epithelial-Mesenchymal Transition in Cancer: A Historical Overview

Domenico Ribatti et al.

TRANSLATIONAL ONCOLOGY (2020)

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Concepts of extracellular matrix remodelling in tumour progression and metastasis

Juliane Winkler et al.

NATURE COMMUNICATIONS (2020)

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Immunoregulatory Roles of Extracellular Vesicles and Associated Therapeutic Applications in Lung Cancer

Zhengrong Yin et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Tuning Cancer Fate: Tumor Microenvironment's Role in Cancer Stem Cell Quiescence and Reawakening

Antonella Sistigu et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Oncology

Dangerous Liaisons: Circulating Tumor Cells (CTCs) and Cancer-Associated Fibroblasts (CAFs)

Pablo Hurtado et al.

CANCERS (2020)

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Cancer-Associated Fibroblasts: Versatile Players in the Tumor Microenvironment

Debolina Ganguly et al.

CANCERS (2020)

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Cancer-Associated Fibroblasts: Understanding Their Heterogeneity

Kevin Louault et al.

CANCERS (2020)

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Review Oncology

Future of immune checkpoint inhibitors: focus on tumor immune microenvironment

Yunlong Jia et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

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Review Cell & Tissue Engineering

Differences and similarities between cancer and somatic stem cells: therapeutic implications

Fiorella Rossi et al.

STEM CELL RESEARCH & THERAPY (2020)

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A review of cancer immunotherapy: from the past, to the present, to the future

K. Esfahani et al.

CURRENT ONCOLOGY (2020)

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Article Oncology

Hypoxia, partial EMT and collective migration: Emerging culprits in metastasis

Kritika Saxena et al.

TRANSLATIONAL ONCOLOGY (2020)

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Review Oncology

The evolving translational potential of small extracellular vesicles in cancer

Andreas Moller et al.

NATURE REVIEWS CANCER (2020)

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Review Biochemistry & Molecular Biology

The updated landscape of tumor microenvironment and drug repurposing

Ming-Zhu Jin et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Review Immunology

A guide to cancer immunotherapy: from T cell basic science to clinical practice

Alex D. Waldman et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Molecular principles of metastasis: a hallmark of cancer revisited

Jawad Fares et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Review Biochemistry & Molecular Biology

Targeting cancer stem cell pathways for cancer therapy

Liqun Yang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Oncology

PRRX1 Regulates Cellular Phenotype Plasticity and Dormancy of Head and Neck Squamous Cell Carcinoma Through miR-642b-3p

Jian Jiang et al.

NEOPLASIA (2019)

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Review Oncology

Heterogeneity in Circulating Tumor Cells: The Relevance of the Stem-Cell Subset

Chiara Agnoletto et al.

CANCERS (2019)

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Article Oncology

The Order of Cancer: A Theory of Malignant Progression by Inverse Morphogenesis

Michael Hoeckel et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Oncology

Evaluating the prognostic significance of tumor-infiltrating lymphocytes in solid tumor: practice of a standardized method from the International Immuno-Oncology Biomarkers Working Group

Jiu-Yang Liu et al.

CANCER MANAGEMENT AND RESEARCH (2019)

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Article Oncology

Progress in cancer survival, mortality, and incidence in seven high-income countries 1995-2014 (ICBP SURVMARK-2): a population-based study

Melina Arnold et al.

LANCET ONCOLOGY (2019)

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CTCs 2020: Great Expectations or Unreasonable Dreams

Elisabetta Rossi et al.

CELLS (2019)

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Bringing radiomics into a multi-omics framework for a comprehensive genotype-phenotype characterization of oncological diseases

Mario Zanfardino et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

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Review Oncology

The clinical role of the TME in solid cancer

Nicolas A. Giraldo et al.

BRITISH JOURNAL OF CANCER (2019)

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Review Cell & Tissue Engineering

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Briana C. Prager et al.

CELL STEM CELL (2019)

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Article Multidisciplinary Sciences

Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity

Michela Capello et al.

NATURE COMMUNICATIONS (2019)

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Article Oncology

Isolation and Identification of Cancer Stem-Like Cells in Adenocarcinoma and Squamous Cell Carcinoma of the Lung: A Pilot Study

Valentina Masciale et al.

FRONTIERS IN ONCOLOGY (2019)

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Marco Romano et al.

FRONTIERS IN IMMUNOLOGY (2019)

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CANCER JOURNAL (2018)

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Zhen Sun et al.

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The viable circulating tumor cells with cancer stem cells feature, where is the way out?

Y. T. Luo et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

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Article Cell Biology

MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer

Sylwia Gawrzak et al.

NATURE CELL BIOLOGY (2018)

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Extracellular vesicles in cancer - implications for future improvements in cancer care

Rong Xu et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Article Oncology

Novel triple-positive markers identified in human non-small cell lung cancer cell line with chemotherapy-resistant and putative cancer stem cell characteristics

Nazilah Abdul Satar et al.

ONCOLOGY REPORTS (2018)

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Review Immunology

Immunotherapies: Exploiting the Immune System for Cancer Treatment

Jeffrey Koury et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2018)

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The crucial role of multiomic approach in cancer research and clinically relevant outcomes

Miaolong Lu et al.

EPMA JOURNAL (2018)

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Editorial Material Oncology

Cancer-Associated Fibroblasts in Pancreatic Cancer: Should They Be Deleted or Reeducated?

Chao Qu et al.

INTEGRATIVE CANCER THERAPIES (2018)

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Article Multidisciplinary Sciences

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

Gang Chen et al.

NATURE (2018)

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Article Oncology

A scoring system to predict recurrence in breast cancer patients

Esther Paredes-Aracil et al.

SURGICAL ONCOLOGY-OXFORD (2018)

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Article Oncology

Local Cancer Recurrence: The Realities, Challenges, and Opportunities for New Therapies

David A. Mahvi et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

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Review Cell Biology

Roles of the immune system in cancer: from tumor initiation to metastatic progression

Hugo Gonzalez et al.

GENES & DEVELOPMENT (2018)

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Review Immunology

Dendritic Cells and CD8 T Cell Immunity in Tumor Microenvironment

Chunmei Fu et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Cell Biology

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Thery et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Oncology

Inflammatory cytokine IL-8/CXCL8 promotes tumour escape from hepatocyte-induced dormancy

Ahmad S. Khazali et al.

BRITISH JOURNAL OF CANCER (2018)

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Review Cell Biology

Cancer stem cells as key drivers of tumour progression

Ain Zubaidah Ayob et al.

JOURNAL OF BIOMEDICAL SCIENCE (2018)

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Article Oncology

Clinical Significance of PD-L1+ Exosomes in Plasma of Head and Neck Cancer Patients

Marie-Nicole Theodoraki et al.

CLINICAL CANCER RESEARCH (2018)

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Article Oncology

Coactivation of Estrogen Receptor and IKK beta Induces a Dormant Metastatic Phenotype in ER-Positive Breast Cancer

Lamiaa El-Shennawy et al.

CANCER RESEARCH (2018)

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Review Cell Biology

Dendritic cell-based immunotherapy

Rachel L. Sabado et al.

CELL RESEARCH (2017)

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Article Medicine, Research & Experimental

CSCs and pluripotent/multipotent stem cells

LABORATORY INVESTIGATION (2017)

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Review Biochemistry & Molecular Biology

Factors involved in cancer metastasis: a better understanding to seed and soil hypothesis

Qiang Liu et al.

MOLECULAR CANCER (2017)

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Review Biochemistry & Molecular Biology

The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer

Pingting Zhou et al.

MOLECULAR CANCER (2017)

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Review Oncology

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

Tsukasa Shibue et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

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Editorial Material Medicine, General & Internal

Tragedy, Perseverance, and Chance - The Story of CAR-T Therapy

Lisa Rosenbaum

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Review Cell Biology

Extracellular vesicles in lung cancer-From bench to bedside

Tsukasa Kadota et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2017)

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Article Cell Biology

Blocking Surgically Induced Lysyl Oxidase Activity Reduces the Risk of Lung Metastases

Chen Rachman-Tzemah et al.

CELL REPORTS (2017)

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Article Immunology

Reprogramming of Tumor-Associated Macrophages with Anticancer Therapies: Radiotherapy versus Chemo- and immunotherapies

Geraldine Genard et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Oncology

PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer

Benjamin A. Kansy et al.

CANCER RESEARCH (2017)

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Article Biochemistry & Molecular Biology

Rationally combining immunotherapies to improve efficacy of immune checkpoint blockade in solid tumors

Floris Dammeijer et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2017)

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Review Oncology

Clinical utility of circulating tumor cells in patients with non-small-cell lung cancer

Marianna Gallo et al.

TRANSLATIONAL LUNG CANCER RESEARCH (2017)

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Review Biochemistry & Molecular Biology

Cancer stem cell surface markers on normal stem cells

Won-Tae Kim et al.

BMB REPORTS (2017)

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Review Biochemistry & Molecular Biology

Emerging Biological Principles of Metastasis

Arthur W. Lambert et al.

CELL (2017)

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Article Oncology

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

Annette Becker et al.

CANCER CELL (2016)

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Article Oncology

Prediction of distant recurrence in resected stage I and II lung adenocarcinoma

Beatrice Aramini et al.

LUNG CANCER (2016)

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Review Oncology

Clinical and biological significance of circulating tumor cells in cancer

Takaaki Masuda et al.

MOLECULAR ONCOLOGY (2016)

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Article Oncology

Prognostic and predictive value of tumor-infiltrating lymphocytes for clinical therapeutic research in patients with non-small cell lung cancer

Dong-Qiang Zeng et al.

ONCOTARGET (2016)

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Article Cell & Tissue Engineering

Cancer Stem Cell Plasticity as Tumor Growth Promoter and Catalyst of Population Collapse

Jan Poleszczuk et al.

STEM CELLS INTERNATIONAL (2016)

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Review Oncology

Circulating tumor cells versus circulating tumor DNA in lung cancer-which one will win?

Silvia Calabuig-Farinas et al.

TRANSLATIONAL LUNG CANCER RESEARCH (2016)

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Article Management

The revolution re-visited: Clinical and genetics research paradigms and the productivity paradox in drug discovery

Michelle Gittelman

RESEARCH POLICY (2016)

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Article Biology

Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study

Mikolaj P. Zaborowski et al.

BIOSCIENCE (2015)

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Article Oncology

Validation of a Molecular and Pathological Model for Five-Year Mortality Risk in Patients with Early Stage Lung Adenocarcinoma

Raphael Bueno et al.

JOURNAL OF THORACIC ONCOLOGY (2015)

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Article Oncology

Non-Small-Cell Lung Cancer Role of the Immune System and Potential for Immunotherapy

David P. Carbone et al.

JOURNAL OF THORACIC ONCOLOGY (2015)

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Letter Oncology

Precision medicine: lessons learned from the SHIVA trial

Apostolia M. Tsimberidou et al.

LANCET ONCOLOGY (2015)

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Review Oncology

Cancer stem cells, cancer cell plasticity and radiation therapy

Erina Vlashi et al.

SEMINARS IN CANCER BIOLOGY (2015)

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Article Multidisciplinary Sciences

NR2F1 controls tumour cell dormancy via SOX9-and RAR beta-driven quiescence programmes

Maria Soledad Sosa et al.

NATURE COMMUNICATIONS (2015)

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Review Oncology

EMT, CTCs and CSCs in tumor relapse and drug-resistance

Abhisek Mitra et al.

ONCOTARGET (2015)

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Review Oncology

A brief history of cancer: Age-old milestones underlying our current knowledge database

Guy B. Faguet

INTERNATIONAL JOURNAL OF CANCER (2015)

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Article Multidisciplinary Sciences

Downregulation of CXCR4 in Metastasized Breast Cancer Cells and Implication in Their Dormancy

Kentaro Nobutani et al.

PLOS ONE (2015)

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Article Multidisciplinary Sciences

Cellular Adhesion Promotes Prostate Cancer Cells Escape from Dormancy

Nazanin Ruppender et al.

PLOS ONE (2015)

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Editorial Material Oncology

A Note From History: Landmarks in History of Cancer, Part 6

Steven I. Hajdu et al.

CANCER (2013)

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Article Oncology

Plastin3 Is a Novel Marker for Circulating Tumor Cells Undergoing the Epithelial-Mesenchymal Transition and Is Associated with Colorectal Cancer Prognosis

Takehiko Yokobori et al.

CANCER RESEARCH (2013)

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Article Oncology

LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis (Publication with Expression of Concern. See vol. 79, pg. 5124, 2019)

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CANCER RESEARCH (2013)

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Article Oncology

Lack of Estrogen Receptor-α Is Associated with Epithelial-Mesenchymal Transition and PI3K Alterations in Endometrial Carcinoma

Elisabeth Wik et al.

CLINICAL CANCER RESEARCH (2013)

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Review Biochemistry & Molecular Biology

Cancer stem cells in solid tumors: an overview and new approaches for their isolation and characterization

Virginia Tirino et al.

FASEB JOURNAL (2013)

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Article Oncology

IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer

Puja Kachroo et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2013)

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Article Endocrinology & Metabolism

Inhibitor of differentiation 1 (Id1) and Id3 proteins play different roles in TGF effects on cell proliferation and migration in prostate cancer cells

Nicole Strong et al.

PROSTATE (2013)

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Article Multidisciplinary Sciences

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

Min Yu et al.

SCIENCE (2013)

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Article Cell Biology

Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance

L. Chang et al.

CELL DEATH & DISEASE (2013)

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Article Cell Biology

TGF-β1 exposure induces epithelial to mesenchymal transition both in CSCs and non-CSCs of the A549 cell line, leading to an increase of migration ability in the CD133+ A549 cell fraction

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CELL DEATH & DISEASE (2013)

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Article Biochemistry & Molecular Biology

The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites

Hua Gao et al.

CELL (2012)

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Article Gastroenterology & Hepatology

Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma

Naoki Oishi et al.

HEPATOLOGY (2012)

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Article Biochemistry & Molecular Biology

Cancer stem cells

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INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)

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Article Oncology

Expression of epithelial-mesenchymal transition-inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy

Michal Mego et al.

INTERNATIONAL JOURNAL OF CANCER (2012)

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Article Oncology

Epithelial-Mesenchymal Transition and Stem Cell Markers in Patients with HER2-Positive Metastatic Breast Cancer

Antonio Giordano et al.

MOLECULAR CANCER THERAPEUTICS (2012)

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Editorial Material Multidisciplinary Sciences

CANCER Solving an age-old problem

Barbara Dunn

NATURE (2012)

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Article Oncology

Prognostic significance of CTCs and CSCs of tumor drainage vein blood in Dukes' stage B and C colorectal cancer patients

Ryu Shimada et al.

ONCOLOGY REPORTS (2012)

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Review Oncology

Combining immunotherapy and targeted therapies in cancer treatment

Matthew Vanneman et al.

NATURE REVIEWS CANCER (2012)

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Review Oncology

Antibody therapy of cancer

Andrew M. Scott et al.

NATURE REVIEWS CANCER (2012)

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Review Immunology

Coordinated regulation of myeloid cells by tumours

Dmitry I. Gabrilovich et al.

NATURE REVIEWS IMMUNOLOGY (2012)

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Article Oncology

A Note From History: Landmarks in History of Cancer, Part 1

Steven I. Haidu

CANCER (2011)

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Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

CELL (2011)

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Article Oncology

The seed and soil hypothesis revisited-The role of tumor-stroma interactions in metastasis to different organs

Robert R. Langley et al.

INTERNATIONAL JOURNAL OF CANCER (2011)

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Article Oncology

Evaluation and Prognostic Significance of Circulating Tumor Cells in Patients With Non-Small-Cell Lung Cancer

Matthew G. Krebs et al.

JOURNAL OF CLINICAL ONCOLOGY (2011)

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Article Oncology

TTF-1 mRNA-positive circulating tumor cells in the peripheral blood predict poor prognosis in surgically resected non-small cell lung cancer patients

Sun Och Yoon et al.

LUNG CANCER (2011)

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Article Multidisciplinary Sciences

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

Bin-Zhi Qian et al.

NATURE (2011)

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Review Oncology

Quiescent, Slow-Cycling StemCell Populations in Cancer: A Review of the Evidence and Discussion of Significance

Nathan Moore et al.

JOURNAL OF ONCOLOGY (2011)

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Article Oncology

Epithelial to mesenchymal transition markers expressed in circulating tumour cells of early and metastatic breast cancer patients

Galatea Kallergi et al.

BREAST CANCER RESEARCH (2011)

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Article Oncology

Metastatic Growth from Dormant Cells Induced by a Col-I-Enriched Fibrotic Environment

Dalit Barkan et al.

CANCER RESEARCH (2010)

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Review Immunology

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

Subhra K. Biswas et al.

NATURE IMMUNOLOGY (2010)

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Article Multidisciplinary Sciences

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

Joseph H. Taube et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Review Pharmacology & Pharmacy

Nanoparticle-assisted combination therapies for effective cancer treatment

Che-Ming Jack Hu et al.

THERAPEUTIC DELIVERY (2010)

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Article Oncology

Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion

Yadi Wu et al.

CANCER CELL (2009)

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Article Oncology

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: N1 versus N2 TAN

Zvi G. Fridlender et al.

CANCER CELL (2009)

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Article Oncology

Computational Identification of a p38SAPK-Regulated Transcription Factor Network Required for Tumor Cell Quiescence

Alejandro P. Adam et al.

CANCER RESEARCH (2009)

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Article Biochemistry & Molecular Biology

Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells

N. J. Sullivan et al.

ONCOGENE (2009)

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Review Immunology

Myeloid-derived suppressor cells as regulators of the immune system

Dmitry I. Gabrilovich et al.

NATURE REVIEWS IMMUNOLOGY (2009)

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Article Oncology

Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton

Dalit Barkan et al.

CANCER RESEARCH (2008)

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Article Multidisciplinary Sciences

Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response

Alexander Swarbrick et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Article Cell Biology

Stemming Cancer: Functional Genomics of Cancer Stem Cells in Solid Tumors

C. R. A. Regenbrecht et al.

STEM CELL REVIEWS (2008)

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Article Multidisciplinary Sciences

ID genes mediate tumor reinitiation during breast cancer lung metastasis

Gaorav P. Gupta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Oncology

Requirement of KISS1 secretion for multiple organ metastasis suppression and maintenance of tumor dormancy

Kevin T. Nash et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2007)

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Review Pharmacology & Pharmacy

In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling

S. Ekins et al.

BRITISH JOURNAL OF PHARMACOLOGY (2007)

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Article Oncology

Tie2 identifies a hematopoietic monocytes required for tumor lineage of proangiogenic vessel formation and a mesenchymal population of pericyte progenitors

M De Palma et al.

CANCER CELL (2005)

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Review Medicine, General & Internal

Tyrosine kinases as targets for cancer therapy

DS Krause et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

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Article Oncology

KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha

Y Jiang et al.

CLINICAL & EXPERIMENTAL METASTASIS (2005)

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Article Oncology

Timeline - Chemotherapy and the war on cancer

BA Chabner et al.

NATURE REVIEWS CANCER (2005)

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Article Cardiac & Cardiovascular Systems

Tumour cells in the tumour draining vein of patients with non-small cell lung cancer: detection rate and clinical significance

W Sienel et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2003)

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Article Cell Biology

Urokinase receptor and fibronectin regulate the ERKMAPK to p38MAPK activity ratios that determine carcinoma cell proliferation or dormancy in vivo

JA Aguirre-Ghiso et al.

MOLECULAR BIOLOGY OF THE CELL (2001)

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