期刊
CANCERS
卷 14, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/cancers14112756
关键词
indoleamine 2,3-dioxygenase 1; tumor microenvironment; interferon-gamma; dendritic cell; myeloid-derived suppressor cell; regulatory T cell
类别
资金
- Fundamental Research Funds for the Central Universities of Central South University [2021zzts1067]
In this article, we review the immunosuppression mechanisms mediated by the IDO1 pathway in tumor growth and discuss the challenges and current clinical research progress in using IDO1 as a new tumor immunotherapy target.
Indoleamine 2, 3-dioxygenase 1 (IDO1) is a rate-limiting enzyme that metabolizes an essential amino acid tryptophan (Trp) into kynurenine (Kyn), and it promotes the occurrence of immunosuppressive effects by regulating the consumption of Trp and the accumulation of Kyn in the tumor microenvironment (TME). Recent studies have shown that the main cellular components of TME interact with each other through this pathway to promote the formation of tumor immunosuppressive microenvironment. Here, we review the role of the immunosuppression mechanisms mediated by the IDO1 pathway in tumor growth. We discuss obstacles encountered in using IDO1 as a new tumor immunotherapy target, as well as the current clinical research progress.
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