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Enhancer RNAs (eRNAs) in Cancer: The Jacks of All Trades

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Summary: Evidence supports the significant involvement of long non-coding RNAs (lncRNAs) in human cancer development, with attention now turning to the role of Enhancer RNAs (eRNAs) in carcinogenesis. In colon adenocarcinoma, LINC02257 emerges as a key eRNA with strong associations to unfavorable prognosis, particularly through its impact on extracellular matrix organization via the PI3K-Akt signaling pathway. Additionally, LINC02257 shows potential as an independent prognostic biomarker and an immunotherapy-related eRNA in various cancers.

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