Current and Emerging Approaches to Study Microenvironmental Interactions and Drug Activity in Classical Hodgkin Lymphoma

Article Hematology

A gene expression-based model predicts outcome in chil-dren with intermediate-risk classical Hodgkin lymphoma

Rebecca L. Johnston et al.

Summary: This study investigates the tumor microenvironment biology of pediatric cHL using gene expression profiling and develops a predictive model for pediatric cHL prognosis. It provides a risk-stratification tool for personalized therapy.

BLOOD (2022)

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Article Pathology

Gene of the month: T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)

Louisa Bolm et al.

Summary: TIGIT, an immune modulator expressed in immune cells, plays a role in cancer progression by regulating T-cell function and cancer cell recognition. Multiple studies have found an association between TIGIT expression and poor survival. Blocking TIGIT can prevent tumor progression, distant metastasis, and tumor recurrence.

JOURNAL OF CLINICAL PATHOLOGY (2022)

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Article Oncology

Classic Hodgkin Lymphoma Refractory for ABVD Treatment Is Characterized by Pathologically Activated Signal Transduction Pathways as Revealed by Proteomic Profiling

Bent Honore et al.

Summary: Patients with classic Hodgkin lymphoma (cHL) refractory to standard ABVD treatment show significant differences in protein expression, indicating potential biological distinctiveness between ABVD sensitive and refractory tumors. Further analysis of the tumor microenvironment and identification of prognostic biomarkers is crucial for improving outcomes.

CANCERS (2022)

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Article Cell Biology

Humanized CD30-Targeted Chimeric Antigen Receptor T Cells Exhibit Potent Preclinical Activity Against Hodgkin's Lymphoma Cells

Jing Guo et al.

Summary: This study demonstrates that CD30-directed CARs constructed using humanized antibody fragments show comparable efficacy to those using mouse antibodies in vitro and in a mouse model. Humanized CARs have the advantages of reducing immune rejection and improving cell persistence.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Chemistry, Analytical

AuNP Aptasensor for Hodgkin Lymphoma Monitoring

Maria Slyusarenko et al.

Summary: A nanozyme-based technique using AuNPs aptasensors was developed to quantify plasma CD30 + SEVs, allowing for monitoring of classical Hodgkin lymphoma (cHL) activity. The method showed good performance in differentiating healthy donors and cHL patients, and a significant decrease in CD30 + SEVs was observed in the plasma of cHL patients after two cycles of chemotherapy.

BIOSENSORS-BASEL (2022)

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Article Hematology

Checkpoint CD47 expression in classical Hodgkin lymphoma

Alex Reza Gholiha et al.

Summary: This study investigated the expression of CD47 in the tumor microenvironment of classical Hodgkin lymphoma and found that high CD47 expression was associated with poorer prognosis. Additionally, CD47 expression did not correlate with SIRPa+ leukocytes or PD-1, PD-L1, and PD-L2 expression.

BRITISH JOURNAL OF HAEMATOLOGY (2022)

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Article Hematology

Inhibitors of ADAM10 reduce Hodgkin lymphoma cell growth in 3D microenvironments and enhance brentuximab-vedotin effect

Roberta Pece et al.

Summary: This study investigates the combined effect of ADAM10 inhibitors and ADC drug BtxVed on lymphoma treatment. By establishing 3D culture models, the study found that ADAM10 inhibitors enhance the anti-lymphoma effect of BtxVed and provide a reliable drug testing tool that recapitulates the LN microenvironment.

HAEMATOLOGICA (2022)

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Letter Hematology

In classical Hodgkin lymphoma the combination of the CCR5 antagonist maraviroc with trabectedin synergizes, enhances DNA damage and decreases three-dimensional tumor-stroma heterospheroid viability

Naike Casagrande et al.

HAEMATOLOGICA (2022)

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Article Hematology

Whole-slide image analysis of the tumor as a predictor of adverse outcome in patients with advanced-stage classical Hodgkin lymphoma treated with BEACOPP

Ron Daniel Jachimowicz et al.

Summary: Whole-slide image analysis (WSI) was used to quantitatively assess tumor composition in patients with advanced-stage classical Hodgkin lymphoma, revealing a significant association between low B-cell count and poor prognosis. T-cell, macrophage, and Hodgkin and Reed-Sternberg cell content were not linked to progression or relapse risk in the study cohort.

HAEMATOLOGICA (2021)

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Article Oncology

Phase I Study of the CD47 Blocker TTI-621 in Patients with Relapsed or Refractory Hematologic Malignancies

Stephen M. Ansell et al.

Summary: The study evaluated the safety and activity of TTI-621 in relapsed/refractory hematologic malignancies, indicating that TTI-621 demonstrated certain therapeutic effects and good tolerability overall in patients.

CLINICAL CANCER RESEARCH (2021)

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Review Oncology

Clinical relevance of extracellular vesicles in hematological neoplasms: from liquid biopsy to cell biopsy

Stefania Trino et al.

Summary: Liquid biopsy is becoming increasingly important in oncology within the era of precision medicine, allowing for the isolation and analysis of tumor-derived biomarkers such as extracellular vesicles (EVs) in body fluids. EVs, as lipid bilayer-enclosed particles, have emerged as valuable carriers of cancer information, offering potential as novel biomarkers due to their molecular cargo mirroring parental cell characteristics. The translation of these new diagnostic tools into clinical practice has the potential to deeply revolutionize the field of cancer research.

LEUKEMIA (2021)

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Article Oncology

Trabectedin overcomes doxorubicin-resistance, counteracts tumor-immunosuppressive reprogramming of monocytes and decreases xenograft growth in Hodgkin lymphoma

Naike Casagrande et al.

Summary: Trabectedin, a novel drug candidate, demonstrates potent antitumor activity against Hodgkin Reed Sternberg cells by targeting tumor cells and the tumor microenvironment. It induces necroptosis, DNA damage, cell cycle arrest, and reduces secretion of inflammatory mediators, as well as inhibits migration. In preclinical studies, trabectedin shows promising results in inhibiting tumor growth and reducing tumor-associated macrophages and angiogenesis in Hodgkin lymphoma xenografts.

CANCER LETTERS (2021)

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Article Biochemical Research Methods

Analysis of clonogenic growth in vitro

Nikko Brix et al.

Summary: The clonogenic assay is a widely used method to measure the ability of single cells to form colonies in vitro, important for identifying and quantifying self-renewing mammalian cells. Different assay principles have been developed to accommodate various research questions and growth requirements of individual cell model systems. Mathematical analysis is essential for optimizing the determination of clonogenic growth parameters.

NATURE PROTOCOLS (2021)

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Review Biochemistry & Molecular Biology

Multicellular 3D Models to Study Tumour-Stroma Interactions

Elisabetta Colombo et al.

Summary: 2D cell cultures have been the standard in various applications, but they cannot replicate the complex and dynamic interactions of the tumor microenvironment (TME). Multicellular 3D models are important for studying the spatial dimension, cellular heterogeneity, and molecular networks of the TME.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

Molecular biology of Hodgkin lymphoma

Marc A. Weniger et al.

Summary: Classical Hodgkin lymphoma (cHL) has unique biological features such as the orchestration of a complex microenvironment by HRS cells, the major role of Epstein-Barr virus in lymphomagenesis, and the defining interplay of genetic lesions and cellular origin. These factors contribute to the constitutive activation of multiple signaling pathways in cHL.

LEUKEMIA (2021)

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Article Hematology

Brentuximab vedotin in combination with nivolumab in relapsed or refractory Hodgkin lymphoma: 3-year study results

Ranjana H. Advani et al.

Summary: This study evaluated the combination of BV and Nivo as first salvage therapy for r/r cHL patients, showing high objective response rate and progression-free survival without additional toxicity concerns. Some patients were able to directly proceed to transplant after study treatment, indicating durable efficacy and impressive outcomes.

BLOOD (2021)

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Article Oncology

Expression of the Immune Checkpoint Regulators LAG-3 and TIM-3 in Classical Hodgkin Lymphoma

Layal El Halabi et al.

Summary: In classical Hodgkin lymphoma, PD-1/PD-L1 blockade has shown great efficacy, and the study found that TIM-3 is frequently expressed in the tumor microenvironment. LAG-3 and TIM-3 may be potential therapeutic targets in the treatment of HL.

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2021)

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Review Medicine, General & Internal

Hodgkin Lymphoma: A Special Microenvironment

Giuseppina Opinto et al.

Summary: Classical Hodgkin's lymphoma is a particular lymphoma characterized by few tumor cells surrounded by an inflammatory microenvironment. The tumor cells reprogram and evade antitumor mechanisms of normal cells, while the microenvironment cells are essential for the growth and survival of the tumor cells. Recent advances in gene expression profiling analysis have been applied to study the microenvironment component in cHL, and therapies targeting both neoplastic cells and the cellular components of the background have been described.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Oncology

Next generation of immune checkpoint inhibitors and beyond

Julian A. Marin-Acevedo et al.

Summary: The immune system plays a crucial role in defending against cancer, but tumor cells can evade immune recognition. Immunotherapy enhances host immune response to combat tumors.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Review Hematology

Adoptive T-cell therapy for Hodgkin lymphoma

Carrie Ho et al.

Summary: Although CAR T-cell therapy has been approved for B-cell non-Hodgkin lymphomas, the progress for classic Hodgkin lymphoma (cHL) has been slower. Early clinical trials have shown promising clinical responses with the use of Epstein-Barr virus-specific cytotoxic T lymphocytes and CD30 CAR T cells in cHL patients, and research on CD19 and CD123 CAR T cells targeting the immunosuppressive tumor microenvironment in cHL is ongoing.

BLOOD ADVANCES (2021)

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Article Multidisciplinary Sciences

A novel scoring system for TIGIT expression in classic Hodgkin lymphoma

Ombretta Annibali et al.

Summary: Immune-checkpoint inhibitors have been effective in treating relapsed/refractory CHL. The study found a correlation between TIGIT expression in T lymphocytes and PD-1 expression, and identified a mutually exclusive expression of TIGIT and PD-L1 using a new scoring system. These results suggest new therapeutic strategies for CHL treatment.

SCIENTIFIC REPORTS (2021)

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Review Oncology

Chorioallantoic membrane vascularization. A meta-analysis

Domenico Ribatti et al.

Summary: The CAM assay is widely used for studying processes like angiogenesis, wound healing, tumor growth, and metastasis. Analyzing and comparing existing literature data on CAM growth can help in better analyzing experimental data on testing various pro-angiogenic and anti-angiogenic molecules. It also allows for a more accurate evaluation and estimation of the angiogenic response to different tumor cell lines.

EXPERIMENTAL CELL RESEARCH (2021)

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Article Oncology

Gene expression-based outcome prediction in advanced stage classical Hodgkin lymphoma treated with BEACOPP

Ron D. Jachimowicz et al.

LEUKEMIA (2021)

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Review Biochemical Research Methods

Spatial omics and multiplexed imaging to explore cancer biology

Sabrina M. Lewis et al.

Summary: Understanding intratumoral heterogeneity through single-cell analyses has revealed new biomarkers, but lacks information on cellular location within the tumor microenvironment. New technologies enabling detection of cancer subclones in their native spatial context promise to drive the next generation of cancer research, diagnosis, and therapeutic strategies.

NATURE METHODS (2021)

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Article Multidisciplinary Sciences

Subcellular localization of biomolecules and drug distribution by high-definition ion beam imaging

Xavier Rovira-Clave et al.

Summary: This study introduces a high-definition multiplex ion beam imaging technology that allows simultaneous visualization of multiple biomolecules and their ligands or small molecules in cells. The subcellular localization of the chemotherapy drug cisplatin was found to be related to chromatin regions, with surviving cells after multi-drug treatment showing selective exclusion of cisplatin from the nucleus, potentially modulating resistance to chemotherapy treatment.

NATURE COMMUNICATIONS (2021)

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Review Oncology

Hodgkin Lymphoma in People Living with HIV

Jose-Tomas Navarro et al.

Summary: HIV-infected individuals have a higher risk of developing Hodgkin lymphoma, with the presence of Epstein-Barr virus playing a crucial role in its etiology. Treatment similar to the general population, including the use of cART and chemotherapy, is recommended for optimal prognosis. Interdisciplinary collaboration between hemato-oncologists and HIV specialists is essential for the management of potential drug interactions and overlapping toxicities.

CANCERS (2021)

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Review Cell Biology

Transcending toward Advanced 3D-Cell Culture Modalities: A Review about an Emerging Paradigm in Translational Oncology

Joviana Farhat et al.

Summary: Cancer is characterized by uncontrolled cell growth and rapid spread, leading to continued experimental investigations due to its complexity and high prevalence. The importance of 3D-cell models in pharmacokinetic studies is increasingly recognized, making them a valuable tool for researchers.

CELLS (2021)

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Article Cell Biology

Extracellular vesicle miRNA predict FDG-PET status in patients with classical Hodgkin Lymphoma

Esther E. E. Drees et al.

Summary: This study showed that miRNAs associated with tumour-secreted EVs in the circulation of cHL patients can improve response assessment. The levels of EV-miRNAs are predictive of metabolic tumour activity in cHL patients, and combining them with TARC protein levels increases the accuracy for predicting PET-status.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Review Cell Biology

Tumor-Derived Extracellular Vesicles: Modulation of Cellular Functional Dynamics in Tumor Microenvironment and Its Clinical Implications

Nathalia Leal Santos et al.

Summary: Extracellular vesicles (EVs) play a crucial role in cancer progression by affecting continuous tumor growth, angiogenesis, metastasis, immune infiltrating cells, and treatment response. Understanding the mechanisms controlling EVs secretion and cargo sorting is essential to impede tumor progression.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Methods to Determine and Analyze the Cellular Spatial Distribution Extracted From Multiplex Immunofluorescence Data to Understand the Tumor Microenvironment

Edwin Roger Parra

Summary: mIF revolutionizes immunohistochemical methods by detecting different proteins in a single tissue section, providing crucial information about cell phenotypes and distribution in tumor samples. Challenges in spatial analysis include extracting meaningful information about cell distribution and understanding how spatial interaction encodes clinical information. Exploratory analysis and mathematical functions help identify key relationships between spatial analysis of cells and established patterns of cellular distribution in tumor samples, enhancing understanding of the tumor microenvironment.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Review Biochemistry & Molecular Biology

Tissue Multiplex Analyte Detection in Anatomic Pathology - Pathways to Clinical Implementation

Keith A. Wharton et al.

Summary: Multiplex tissue analysis using immunofluorescence has the potential to enhance pathologic diagnosis by providing insights into tissue-level biology and single-cell phenotypes that traditional methods cannot address. Widespread implementation will require improved detection chemistry, greater standardization of workflows and data pipelines, and integration of multichannel images into digital pathology systems, with interpretation aided by AI. Adoption will also depend on evidence justifying clinical use, regulatory pathways, and adequate budgets and reimbursement.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Medicine, General & Internal

Proteomic Exploration of Plasma Exosomes and Other Small Extracellular Vesicles in Pediatric Hodgkin Lymphoma: A Potential Source of Biomarkers for Relapse Occurrence

Ombretta Repetto et al.

Summary: The study analyzed EV proteins in plasma from pediatric Hodgkin lymphoma patients using proteomic techniques, identifying potential predictive biomarkers for relapse. Differential abundance of specific proteins was found between non-relapsed and relapsed cases, suggesting their potential role in disease progression and prognosis. Functional analysis of EV proteins revealed involvement in platelet degranulation and serine-type endopeptidase activity as significant biological processes and molecular functions.

DIAGNOSTICS (2021)

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Article Hematology

Avelumab in relapsed/refractory classical Hodgkin lymphoma: phase 1b results from the JAVELIN Hodgkins trial

Alex F. Herrera et al.

Summary: The study investigated the use of avelumab in patients with relapsed/refractory cHL and found that it was well tolerated and showed anti-tumor activity even in heavily pretreated patients. PD-L1 blockade may be sufficient for therapeutic benefit in cHL patients.

BLOOD ADVANCES (2021)

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Review Oncology

Immune Microenvironment Features and Dynamics in Hodgkin Lymphoma

Clara Bertuzzi et al.

Summary: Hodgkin lymphoma is a hematologic malignancy characterized by a unique composition of reactive cells and neoplastic cells. The microenvironment plays a significant role in shaping the pathogenesis and prognosis of classical Hodgkin's lymphoma, highlighting its potential as a therapeutic target. This review focuses on the interaction between Hodgkin cells and the microenvironment, as well as the impact on immune cell populations and their functional status.

CANCERS (2021)

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Review Oncology

3D In Vitro Model (R)evolution: Unveiling Tumor-Stroma Interactions

Joao Rodrigues et al.

Summary: Understanding the interactions between cancer cells and their surrounding tissue, known as the tumor microenvironment, is crucial for cancer progression. 3D in vitro models are valuable tools that help bridge the gap between oversimplified 2D systems and unrepresentative animal models in studying tumor-stroma interactions. By focusing on the tumor microenvironment as a key target in cancer therapy, researchers can gain deeper insights into disease progression.

TRENDS IN CANCER (2021)

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Article Oncology

Expression of CD47 antigen in Reed-Sternberg cells as a new potential biomarker for classical Hodgkin lymphoma

B. Lopez-Pereira et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2020)

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Article Oncology

A Gene Expression-based Model to Predict Metabolic Response After Two Courses of ABVD in Hodgkin Lymphoma Patients

Stefano Luminari et al.

CLINICAL CANCER RESEARCH (2020)

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Article Oncology

Mass cytometry defines distinct immune profile in germinal center B-cell lymphomas

Mikael Roussel et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

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Article Oncology

Inhibition of MDR1 Overcomes Resistance to Brentuximab Vedotin in Hodgkin Lymphoma

Robert Chen et al.

CLINICAL CANCER RESEARCH (2020)

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Article Oncology

PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma

Masaharu Kawashima et al.

LEUKEMIA (2020)

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Article Oncology

High CD206 levels in Hodgkin lymphoma-educated macrophages are linked to matrix-remodeling and lymphoma dissemination

Annekatrin Arlt et al.

MOLECULAR ONCOLOGY (2020)

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Article Oncology

Single-Cell Transcriptome Analysis Reveals Disease-Defining T-cell Subsets in the Tumor Microenvironment of Classic Hodgkin Lymphoma

Tomohiro Aoki et al.

CANCER DISCOVERY (2020)

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Review Pathology

Clinical Application of Image Analysis in Pathology

Toby C. Cornish

ADVANCES IN ANATOMIC PATHOLOGY (2020)

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Article Hematology

Hodgkin lymphoma: A 2020 update on diagnosis, risk-stratification, and management

Stephen M. Ansell

AMERICAN JOURNAL OF HEMATOLOGY (2020)

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Article Oncology

A20 and RBX1 Regulate Brentuximab Vedotin Sensitivity in Hodgkin Lymphoma Models

Wei Wei et al.

CLINICAL CANCER RESEARCH (2020)

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Review Immunology

Role of ADAM10 as a CD30 Sheddase in Classical Hodgkin Lymphoma

Hinrich P. Hansen et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Oncology

Prognostic Impact of Tumor-Associated Macrophages on Survival Is Checkpoint Dependent in Classical Hodgkin Lymphoma

Kristiina Karihtala et al.

CANCERS (2020)

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Article Biotechnology & Applied Microbiology

Multiplex digital spatial profiling of proteins and RNA in fixed tissue

Christopher R. Merritt et al.

NATURE BIOTECHNOLOGY (2020)

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Article Hematology

Rosetting T cells in Hodgkin lymphoma are activated by immunological synapse components HLA class II and CD58

Johanna Veldman et al.

BLOOD (2020)

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Article Medicine, General & Internal

Hodgkin lymphoma

Joseph M. Connors et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

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Article Oncology

Anti-CD30 CAR-T Cell Therapy in Relapsed and Refractory Hodgkin Lymphoma

Carlos A. Ramos et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Multidisciplinary Sciences

Tumor-associated macrophages in classical Hodgkin lymphoma: hormetic relationship to outcome

Laura Werner et al.

SCIENTIFIC REPORTS (2020)

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Review Pharmacology & Pharmacy

Ex vivo cultures and drug testing of primary acute myeloid leukemia samples: Current techniques and implications for experimental design and outcome

D. G. J. Cucchi et al.

DRUG RESISTANCE UPDATES (2020)

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Review Immunology

Tumor-Associated Macrophages in Tumor Immunity

Yueyun Pan et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Pharmacology & Pharmacy

Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research

Barbara Pinto et al.

PHARMACEUTICS (2020)

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Review Oncology

The role of trogocytosis in immune surveillance of Hodgkin lymphoma

Qun Zeng et al.

ONCOIMMUNOLOGY (2020)

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Article Oncology

Reverse signaling via PD-L1 supports malignant cell growth and survival in classical Hodgkin lymphoma

Shahrzad Jalali et al.

BLOOD CANCER JOURNAL (2019)

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Review Biochemistry & Molecular Biology

Formation of the Immunosuppressive Microenvironment of Classic Hodgkin Lymphoma and Therapeutic Approaches to Counter It

Donatella Aldinucci et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Hematology

An etiological role for the Epstein-Barr virus in the pathogenesis of classical Hodgkin lymphoma

Paul G. Murray et al.

BLOOD (2019)

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Article Hematology

The microenvironmental niche in classic Hodgkin lymphoma is enriched for CTLA-4-positive T cells that are PD-1-negative

Sanjay S. Patel et al.

BLOOD (2019)

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Review Multidisciplinary Sciences

A view on drug resistance in cancer

Neil Vasan et al.

NATURE (2019)

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Article Oncology

Migration Properties Distinguish Tumor Cells of Classical Hodgkin Lymphoma from Anaplastic Large Cell Lymphoma Cells

Olga Goncharova et al.

CANCERS (2019)

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Article Oncology

Fibroblasts in Nodular Sclerosing Classical Hodgkin Lymphoma Are Defined by a Specific Phenotype and Protect Tumor Cells from Brentuximab-Vedotin Induced Injury

Katrin Bankov et al.

CANCERS (2019)

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Article Hematology

High tumour plasma cell infiltration reflects an important microenvironmental component in classic Hodgkin lymphoma linked to presence of B-symptoms

Alex R. Gholiha et al.

BRITISH JOURNAL OF HAEMATOLOGY (2019)

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Article Oncology

Targeting Cancer Cells and Tumor Microenvironment in Preclinical and Clinical Models of Hodgkin Lymphoma Using the Dual PI3Kδ/γ Inhibitor RP6530

Silvia L. Locatelli et al.

CLINICAL CANCER RESEARCH (2019)

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Article Hematology

CCR5 antagonism by maraviroc inhibits Hodgkin lymphoma microenvironment interactions and xenograft growth

Naike Casagrande et al.

HAEMATOLOGICA (2019)

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Article Oncology

Co-targeting of Tiam1/Rac1 and Notch ameliorates chemoresistance against doxorubicin in a biomimetic 3D lymphoma model

Muhammad Ikram et al.

ONCOTARGET (2018)

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Article Cell Biology

Trogocytosis of ligand-receptor complex and its intracellular transport in CD30 signalling

Makoto Nakashima et al.

BIOLOGY OF THE CELL (2018)

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Article Hematology

Mass cytometry of Hodgkin lymphoma reveals a CD4+ regulatory T-cell-rich and exhausted T-effector microenvironment

Fathima Zumla Cader et al.

BLOOD (2018)

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Review Hematology

Biology of classical Hodgkin lymphoma: implications for prognosis and novel therapies

Anja Mottok et al.

BLOOD (2018)

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Article Hematology

CD83 is a new potential biomarker and therapeutic target for Hodgkin lymphoma

Ziduo Li et al.

HAEMATOLOGICA (2018)

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Article Biology

Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes

Jia-Ren Lin et al.

ELIFE (2018)

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Article Hematology

CD83 is a new potential biomarker and therapeutic target for Hodgkin lymphoma

Ziduo Li et al.

HAEMATOLOGICA (2018)

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Article Immunology

Hodgkin Lymphoma-Derived Extracellular Vesicles Change the Secretome of Fibroblasts Toward a CAF Phenotype

Bastian Doersam et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Oncology

Specific ADAM10 inhibitors localize in exosome-like vesicles released by Hodgkin lymphoma and stromal cells and prevent sheddase activity carried to bystander cells

Francesca Tosetti et al.

ONCOIMMUNOLOGY (2018)

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Article Biochemistry & Molecular Biology

Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging

Yury Goltsev et al.

CELL (2018)

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Article Oncology

Expression of the immune checkpoint receptor TIGIT in Hodgkin's lymphoma

Wenchao Li et al.

BMC CANCER (2018)

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Meeting Abstract Hematology

Characterization of Myeloid-Derived Suppressor Cells and Tumor Associated Macrophages Using MultiOmyx™ Hyperplexed Immunofluorescence Assay in Hodgkin Lymphoma

Qingyan Au et al.

BLOOD (2018)

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Review Oncology

The impact of EBV and HIV infection on the microenvironmental niche underlying Hodgkin lymphoma pathogenesis

Antonino Carbone et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

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Article Oncology

Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma

F. Linke et al.

LEUKEMIA (2017)

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Article Biochemistry & Molecular Biology

WNT5A: a motility-promoting factor in Hodgkin lymphoma

F. Linke et al.

ONCOGENE (2017)

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Review Oncology

Tumour-associated macrophages as treatment targets in oncology

Alberto Mantovani et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

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Article Oncology

Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells

Marco Ruella et al.

CANCER DISCOVERY (2017)

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Article Oncology

Complex Immune Evasion Strategies in Classical Hodgkin Lymphoma

Frederik Wein et al.

CANCER IMMUNOLOGY RESEARCH (2017)

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Article Hematology

Topological analysis reveals a PD-L1-associated microenvironmental niche for Reed-Sternberg cells in Hodgkin lymphoma

Christopher D. Carey et al.

BLOOD (2017)

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Article Hematology

Tumour-associated mast cells in classical Hodgkin's lymphoma: correlation with histological subtype, other tumour-infiltrating inflammatory cell subsets and outcome

Maja D. Andersen et al.

EUROPEAN JOURNAL OF HAEMATOLOGY (2016)

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Article Oncology

ADAM10 new selective inhibitors reduce NKG2D ligand release sensitizing Hodgkin lymphoma cells to NKG2D-mediated killing

Maria Raffaella Zocchi et al.

ONCOIMMUNOLOGY (2016)

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Review Oncology

Microenvironmental interactions in classical Hodgkin lymphoma and their role in promoting tumor growth, immune escape and drug resistance

Donatella Aldinucci et al.

CANCER LETTERS (2016)

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Article Hematology

The role of tumour-infiltrating eosinophils, mast cells and macrophages in Classical and Nodular Lymphocyte Predominant Hodgkin Lymphoma in children

Annika Englund et al.

EUROPEAN JOURNAL OF HAEMATOLOGY (2016)

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Review Hematology

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Current and Emerging Approaches to Study Microenvironmental Interactions and Drug Activity in Classical Hodgkin Lymphoma

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