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Therapeutic Strategies Focused on Cancer-Associated Hypercoagulation for Ovarian Clear Cell Carcinoma

CANCERS (2022)

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Summary: We identified an immune subtype of ovarian clear cell carcinoma with poor survival and enrichment of PD-1 and PI3K-AKT-mTOR signaling. We constructed and validated a robust prognostic immune signature for patients with ovarian clear cell carcinoma.

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Summary: The study examined the expression of PDPN in ovarian cancer and its role in tumor progression and venous thrombosis. The findings demonstrated that PDPN expression in ovarian cancer cells promotes tumor growth and is associated with thrombosis.

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Ryuta Miyake et al.

Summary: This study assessed the diagnostic performance of tissue factor pathway inhibitor 2 (TFPI2) in patients with epithelial ovarian cancer (EOC) and positive D-dimer results for venous thromboembolism (VTE). The results showed that serum TFPI2 levels were significantly higher in patients with VTE compared to those without VTE. TFPI2 may serve as a diagnostic marker for VTE in patients with EOC and positive D-dimer results.

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A pan-cancer analysis of the human tumor coagulome and its link to the tumor immune microenvironment

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Metformin Is Associated with Reduced Tissue Factor Procoagulant Activity in Patients with Poorly Controlled Diabetes

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Cost-Effectiveness of Venous Thromboembolism Prophylaxis During Neoadjuvant Chemotherapy for ovarian Cancer

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Summary: Clear cell carcinoma of the ovary has unique biological features and clinical manifestations. There are significant differences in incidence based on geography and race, with younger patients often presenting at early stages and having tumors associated with endometriosis. Specific gene mutations, such as ARID1A and PIK3CA, are common in this type of carcinoma.

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The timing of venous thromboembolism in ovarian cancer patients: A nationwide Danish cohort study

Henriette Strom Kahr et al.

Summary: The study found that patients with epithelial ovarian cancer are at high risk of VTE, especially within the first year after diagnosis. Major pelvic surgery and chemotherapy were strongly associated with VTE risk, while person-related risk factors included increasing age and previous VTE. These findings support the indication for thrombosis prophylaxis during chemotherapy.

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Lu Ye et al.

Summary: This study revealed that the prevalence of chemotherapy-related VTE in ovarian cancer patients was approximately 9%. Significant risk factors for chemotherapy-related VTE were identified, which may contribute to targeting potentially preventative measures for VTE in ovarian cancer. The prognostic value of VTE in ovarian cancer patients receiving chemotherapy remains inconclusive and further research is needed.

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Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy

Eric H. Bent et al.

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NATURE COMMUNICATIONS (2021)

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Venous thromboembolism in cancer patients: a population-based cohort study

F. Mulder et al.

Summary: Over the past decade, the incidence of venous thromboembolism (VTE) in cancer patients may have changed due to novel cancer therapies, improved survival, and high-resolution imaging. The risk of VTE in cancer patients is steadily increasing and is ninefold higher than in the general population.

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Etsuko Miyagi et al.

Summary: TFPI2 is a novel serum biomarker that shows high specificity for preoperative detection of ovarian clear cell carcinoma (CCC). It performs well in discriminating CCC from other ovarian tumors and benign lesions, and combined with CA125 can improve diagnostic sensitivity. TFPI2 and CA125 may contribute substantially to precise prediction of intractable CCC.

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Maximilian Haist et al.

Summary: The study provides clinical evidence that the clinical application of FXa inhibitors may enhance the efficacy of ICI therapy by restoring anti-tumor immunity, while patients who received FXa inhibitors were not more likely to experience bleeding complications.

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Xin Wang et al.

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Summary: The study evaluated the addition of the humanized monoclonal antiprogrammed death ligand-1 (PD-L1) antibody atezolizumab to platinum-based chemotherapy and bevacizumab in newly diagnosed stage III or IV ovarian cancer, showing a significant progression-free survival advantage in the PD-L1-positive population. However, no significant overall survival benefit was observed from atezolizumab in the interim analysis. The most common grade 3 or 4 adverse events were neutropenia, hypertension, and anemia.

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High prevalence of pulmonary embolism prior to cancer therapies in patients with ovarian and endometrial cancers detected by contrast-enhanced CT using D-dimer as an index

Yuji Habu et al.

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Summary: This study evaluated the efficacy and safety of tisotumab vedotin in women with recurrent or metastatic cervical cancer. The drug showed clinically meaningful and durable antitumour activity with a manageable and tolerable safety profile in this patient population. Tisotumab vedotin could represent a new treatment option for women with recurrent or metastatic cervical cancer.

LANCET ONCOLOGY (2021)

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Luyi Li et al.

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Toshiyuki Seki et al.

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Ken Yamaguchi et al.

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CANCERS (2021)

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Treatment Strategies for ARID1A-Deficient Ovarian Clear Cell Carcinoma

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Summary: Ovarian clear cell carcinoma (OCCC) is a histological subtype of ovarian cancer prevalent in Asian countries, with deleterious mutations in SWI/SNF chromatin remodeling genes like ARID1A being common. Therapeutic strategies based on SWI/SNF deficiency, such as gemcitabine-based chemotherapy, synthetic lethal therapy, and immune checkpoint blockade therapy, have the potential to improve patient prognosis by targeting vulnerabilities unique to OCCC.

CANCERS (2021)

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Sequential Phase II clinical trials evaluating CRLX101 as monotherapy and in combination with bevacizumab in recurrent ovarian cancer

Carolyn N. Krasner et al.

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Ryo Tamura et al.

Summary: The study found that ovarian clear cell carcinoma (CCC) is often associated with a hypercoagulable state leading to higher incidence of thromboembolism, and elevated D-dimer levels are correlated with poor prognosis in CCC patients. CCC with high D-dimer levels exhibit distinct molecular characteristics involving inflammatory and immune-suppressive pathways.

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CANCER SCIENCE (2018)

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Review Cell Biology

Prognostic Role of Pretreatment Plasma D-Dimer in Patients with Solid Tumors: a Systematic Review and Meta-Analysis

Wenhan Li et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Article Oncology

Genomic landscape of ovarian clear cell carcinoma via whole exome sequencing

Se Ik Kim et al.

GYNECOLOGIC ONCOLOGY (2018)

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Article Oncology

A phase II evaluation of sunitinib in the treatment of persistent or recurrent clear cell ovarian carcinoma: An NRG Oncology/Gynecologic Oncology Group Study (GOG-254)

John K. Chan et al.

GYNECOLOGIC ONCOLOGY (2018)

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Article Oncology

Phase II study of single-agent cabozantinib in patients with recurrent clear cell ovarian, primary peritoneal or fallopian tube cancer (NRG-GY001)

Panagiotis A. Konstantinopoulos et al.

GYNECOLOGIC ONCOLOGY (2018)

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Article Hematology

Impact of interleukin 6 promoter polymorphisms (-174 G > C,-572 G > C and-597 G > A) on plasma IL-6 levels and their influence on the development of DVT: a study from India

Amit Sharma et al.

HEMATOLOGY (2018)

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Article Oncology

Clinical associations of Trousseau's syndrome associated with cerebral infarction and ovarian cancer

Hirokuni Takano et al.

JOURNAL OF GYNECOLOGIC ONCOLOGY (2018)

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Article Hematology

Combination of isocitrate dehydrogenase 1 (IDH1) mutation and podoplanin expression in brain tumors identifies patients at high or low risk of venous thromboembolism

P. Mir Seyed Nazari et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2018)

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Article Medicine, General & Internal

Risk factors for deep venous thrombosis in women with ovarian cancer

Yasuhiko Ebina et al.

MEDICINE (2018)

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Review Immunology

Role of C-Reactive Protein at Sites of Inflammation and Infection

Nicola R. Sproston et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Oncology

Treating Tissue Factor-Positive Cancers with Antibody-Drug Conjugates That Do Not Affect Blood Clotting

Jan-Willem Theunissen et al.

MOLECULAR CANCER THERAPEUTICS (2018)

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Letter Obstetrics & Gynecology

Further Evidence for Hypercoagulability in Women With Ovarian Endometriomas

Ding Ding et al.

REPRODUCTIVE SCIENCES (2018)

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Article Cell Biology

Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium

Kazuaki Suda et al.

CELL REPORTS (2018)

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Review Medical Laboratory Technology

D-dimer: Preanalytical, analytical, postanalytical variables, and clinical applications

Julien Favresse et al.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2018)

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Review Oncology

Impacts of Cancer on Platelet Production, Activation and Education and Mechanisms of Cancer-Associated Thrombosis

Lea Plantureux et al.

CANCERS (2018)

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Review Oncology

Cancer-Associated Thrombosis: An Overview of Mechanisms, Risk Factors, and Treatment

Norbaini Binti Abdol Razak et al.

CANCERS (2018)

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Article Obstetrics & Gynecology

Aspirin use correlates with survival in women with clear cell ovarian cancer

Alyssa M. Wield et al.

GYNECOLOGIC ONCOLOGY REPORTS (2018)

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Article Oncology

An evaluation of progression free survival and overall survival of ovarian cancer patients with clear cell carcinoma versus serous carcinoma treated with platinum therapy: An NRG Oncology/Gynecologic Oncology Group experience

Kate E. Oliver et al.

GYNECOLOGIC ONCOLOGY (2017)

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Article Oncology

Evaluation of venous thrombosis and tissue factor in epithelial ovarian cancer

Joshua G. Cohen et al.

GYNECOLOGIC ONCOLOGY (2017)

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Article Cardiac & Cardiovascular Systems

Risk of Arterial Thromboembolism in Patients With Cancer

Babak B. Navi et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

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Review Hematology

Tissue factor-bearing microparticles and inflammation: a potential mechanism for the development of venous thromboembolism in cancer

K. Date et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2017)

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Article Medicine, General & Internal

Cancer-Associated Mutations in Endometriosis without Cancer

M. S. Anglesio et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Obstetrics & Gynecology

Incidence and Timing of Thromboembolic Events in Patients With Ovarian Cancer Undergoing Neoadjuvant Chemotherapy

Patricia S. Greco et al.

OBSTETRICS AND GYNECOLOGY (2017)

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Article

Heparin antagonizes cisplatin resistance of A2780 ovarian cancer cells by affecting the Wnt signaling pathway

Daniel Bastian Pfankuchen et al.

Oncotarget (2017)

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Article Oncology

Plasminogen activator inhibitor-1 is an independent prognostic factor of ovarian cancer and IMD-4482, a novel plasminogen activator inhibitor-1 inhibitor, inhibits ovarian cancer peritoneal dissemination

Erika Nakatsuka et al.

ONCOTARGET (2017)

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Review Immunology

Resolution of Cancer-Promoting inflammation: A New Approach for Anticancer Therapy

Qi Zhang et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Pathology

Exome Sequencing Landscape Analysis in Ovarian Clear Cell Carcinoma Shed Light on Key Chromosomal Regions and Mutation Gene Networks

Ryusuke Murakami et al.

AMERICAN JOURNAL OF PATHOLOGY (2017)

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Review Hematology

Cancer-associated pathways and biomarkers of venous thrombosis

Yohei Hisada et al.

BLOOD (2017)

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Article Oncology

Whole-genome sequencing revealed novel prognostic biomarkers and promising targets for therapy of ovarian clear cell carcinoma

Hiroaki Itamochi et al.

BRITISH JOURNAL OF CANCER (2017)

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Meeting Abstract Oncology

Phase II clinical and molecular trial of oral ENMD-2076 in clear cell ovarian cancer (CCOC): A study of the Princess Margaret phase II consortium.

Stephanie Lheureux et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

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Article Oncology

ALK-Rearranged Non-Small-Cell Lung Cancer Is Associated With a High Rate of Venous Thromboembolism

Alona Zer et al.

CLINICAL LUNG CANCER (2017)

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Article Endocrinology & Metabolism

Effects of the hypoxia-inducible factor-1 inhibitor echinomycin on vascular endothelial growth factor production and apoptosis in human ectopic endometriotic stromal cells

Tomoko Tsuzuki et al.

GYNECOLOGICAL ENDOCRINOLOGY (2016)

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Article Clinical Neurology

Mutant IDH1 and thrombosis in gliomas

Dusten Unruh et al.

ACTA NEUROPATHOLOGICA (2016)

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Review Pathology

The Dualistic Model of Ovarian Carcinogenesis Revisited, Revised, and Expanded

Robert J. Kurman et al.

AMERICAN JOURNAL OF PATHOLOGY (2016)

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Article Oncology

Clear-cell carcinoma of the ovary

K. Fujiwara et al.

ANNALS OF ONCOLOGY (2016)

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Review Biochemistry & Molecular Biology

Hypoxia-inducible factor-1 alpha: A promising therapeutic target in endometriosis

Lei Zhan et al.

BIOCHIMIE (2016)

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Article Oncology

Ovarian Cancer Risk Factors by Histologic Subtype: An Analysis From the Ovarian Cancer Cohort Consortium

Nicolas Wentzensen et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

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Review Oncology

Clear cell carcinoma of the ovary: molecular insights and future therapeutic perspectives

Seiji Mabuchi et al.

JOURNAL OF GYNECOLOGIC ONCOLOGY (2016)

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Article Multidisciplinary Sciences

Clinical Significance of Tissue Factor Pathway Inhibitor 2, a Serum Biomarker Candidate for Ovarian Clear Cell Carcinoma

Noriaki Arakawa et al.

PLOS ONE (2016)

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Article Cardiac & Cardiovascular Systems

Tissue factor as a link between inflammation and coagulation

Marco Witkowski et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2016)

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Meeting Abstract Oncology

A phase II evaluation of temsirolimus in combination with carboplatin and paclitaxel followed by temsirolimus consolidation as first-line therapy in the treatment of stage III-IV clear cell carcinoma of the ovary.

John H. Farley et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

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Review Medicine, General & Internal

Blood biomarkers for the non-invasive diagnosis of endometriosis

Vicki Nisenblat et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2016)

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Review Pharmacology & Pharmacy

Pharmacology of Heparin and Related Drugs

Barbara Mulloy et al.

PHARMACOLOGICAL REVIEWS (2016)

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Article Oncology

A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer

E. M. Dijkgraaf et al.

ANNALS OF ONCOLOGY (2015)

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Article Pharmacology & Pharmacy

Low molecular weight heparin tinzaparin antagonizes cisplatin resistance of ovarian cancer cells

Daniel Bastian Pfankuchen et al.

BIOCHEMICAL PHARMACOLOGY (2015)

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Article Oncology

Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer

Satsuki Mashiko et al.

CANCER BIOLOGY & THERAPY (2015)

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Review Oncology

Plasminogen Activator Inhibitor-1 in Cancer: Rationale and Insight for Future Therapeutic Testing

Veronica R. Placencio et al.

CANCER RESEARCH (2015)

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Article Oncology

Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma

Koji Matsuo et al.

EUROPEAN JOURNAL OF CANCER (2015)

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Article Oncology

High Pretreatment Plasma D-dimer Levels Are Associated With Poor Prognosis in Patients With Ovarian Cancer Independently of Venous Thromboembolism and Tumor Extension

Manabu Sakurai et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2015)

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Article Oncology

Pretreatment Plasma D-Dimer, Fibrinogen, and Platelet Levels Significantly Impact Prognosis in Patients With Epithelial Ovarian Cancer Independently of Venous Thromboembolism

Ya-Nan Man et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2015)

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Article Oncology

Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden

Michael S. Anglesio et al.

JOURNAL OF PATHOLOGY (2015)

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Article Hematology

Tumor oncogene (KRAS) status and risk of venous thrombosis in patients with metastatic colorectal cancer

S. Ades et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2015)

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Article Multidisciplinary Sciences

Increased Levels of NF-κB-Dependent Markers in Cancer-Associated Deep Venous Thrombosis

Grazia Malaponte et al.

PLOS ONE (2015)

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Article Obstetrics & Gynecology

Evidence for a Hypercoagulable State in Women With Ovarian Endometriomas

Qinjiao Wu et al.

REPRODUCTIVE SCIENCES (2015)

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Article Hematology

Incidence of Ct scan-detected pulmonary embolism in patients with oncogene-addicted, advanced lung adenocarcinoma

Melina Verso et al.

THROMBOSIS RESEARCH (2015)

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Article Multidisciplinary Sciences

Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling

Ronald L. Chandler et al.

NATURE COMMUNICATIONS (2015)

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Article Oncology

A Phase I/II, Multiple-Dose, Dose-Escalation Study of Siltuximab, an Anti-Interleukin-6 Monoclonal Antibody, in Patients with Advanced Solid Tumors

Eric Angevin et al.

CLINICAL CANCER RESEARCH (2014)

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Review Oncology

Gynecologic Cancer InterGroup (GCIG) Consensus Review for Clear Cell Carcinoma of the Ovary

Aikou Okamoto et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2014)

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Article Immunology

PD-L1 is a novel direct target of HIF-1α., and its blockade under hypoxia enhanced MDSC-mediated T cell activation

Muhammad Zaeem Noman et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

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Article Hematology

Mutations in NSCLC and their link with lung cancer-associated thrombosis: A case-control study

Luis Corrales-Rodriguez et al.

THROMBOSIS RESEARCH (2014)

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Article Hematology

Oncogenes and the coagulation system - forces that modulate dormant and aggressive states in cancer

Nathalie Magnus et al.

THROMBOSIS RESEARCH (2014)

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Article Obstetrics & Gynecology

Venous thromboembolism in ovarian cancer: incidence, risk factors and impact on survival

Feras Abu Saadeh et al.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2013)

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Article Obstetrics & Gynecology

Eutopic and ectopic stromal cells from patients with endometriosis exhibit differential invasive, adhesive, and proliferative behavior

Ali-Akbar Delbandi et al.

FERTILITY AND STERILITY (2013)

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Article Oncology

Venous thromboembolism during primary treatment of ovarian clear cell carcinoma is associated with decreased survival

Elena S. Diaz et al.

GYNECOLOGIC ONCOLOGY (2013)

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Article Biochemical Research Methods

Secretome-Based Identification of TFPI2, A Novel Serum Biomarker for Detection of Ovarian Clear Cell Adenocarcinoma

Noriaki Arakawa et al.

JOURNAL OF PROTEOME RESEARCH (2013)

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Article Multidisciplinary Sciences

Integrative Bioinformatics Links HNF1B with Clear Cell Carcinoma and Tumor-Associated Thrombosis

Justin Cuff et al.

PLOS ONE (2013)

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Article Oncology

Elevated preoperative plasma D-dimer levels and the incidence of venous thromboembolism in Japanese females with gynecological cancer

Junichi Kodama et al.

ONCOLOGY LETTERS (2013)

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Review Oncology

Clear cell carcinoma of the ovary: A review of the literature

Marcela G. del Carmen et al.

GYNECOLOGIC ONCOLOGY (2012)

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Article Hematology

High D-dimer levels are associated with poor prognosis in cancer patients

Cihan Ay et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2012)

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Article Oncology

Cytokine gene expression signature in ovarian clear cell carcinoma

Nozomu Yanaihara et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2012)

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Article Oncology

Cut-off value of D-dimer for prediction of deep venous thrombosis before treatment in ovarian cancer

Ryuji Kawaguchi et al.

JOURNAL OF GYNECOLOGIC ONCOLOGY (2012)

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Article Oncology

Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies

Celeste Leigh Pearce et al.

LANCET ONCOLOGY (2012)

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Article Medicine, General & Internal

Paraneoplastic Thrombocytosis in Ovarian Cancer

Rebecca L. Stone et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

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Review Medicine, General & Internal

Risk of Venous Thromboembolism in Patients with Cancer: A Systematic Review and Meta-Analysis

Freesia Horsted et al.

PLOS MEDICINE (2012)

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Article Hematology

Long-term use of vitamin K antagonists and incidence of cancer: a population-based study

Vittorio Pengo et al.

BLOOD (2011)

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Review Oncology

Aspirin and cancer: has aspirin been overlooked as an adjuvant therapy?

R. E. Langley et al.

BRITISH JOURNAL OF CANCER (2011)

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Article Oncology

IL6-STAT3-HIF Signaling and Therapeutic Response to the Angiogenesis Inhibitor Sunitinib in Ovarian Clear Cell Cancer

Michael S. Anglesio et al.

CLINICAL CANCER RESEARCH (2011)

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Article Oncology

Prognosis of ovarian clear cell carcinoma compared to other histological subtypes: A meta-analysis

Yoo-Young Lee et al.

GYNECOLOGIC ONCOLOGY (2011)

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Article Medicine, General & Internal

Incorporation of Bevacizumab in the Primary Treatment of Ovarian Cancer

Robert A. Burger et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Article Medicine, General & Internal

A Phase 3 Trial of Bevacizumab in Ovarian Cancer

Timothy J. Perren et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Editorial Material Medicine, General & Internal

Statins to Prevent Venous Thromboembolism in Patients with Cancer?

James E. Dalen

AMERICAN JOURNAL OF MEDICINE (2010)

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Article Oncology

When 'never-events' occur despite adherence to clinical guidelines: The case of venous thromboembolism in clear cell cancer of the ovary compared with other epithelial histologic subtypes

Linda R. Duska et al.

GYNECOLOGIC ONCOLOGY (2010)

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Article Obstetrics & Gynecology

Expression of Podoplanin in Epithelial Ovarian Carcinomas and its Potential as a Marker for Clear Cell Adenocarcinoma

Shuko Oe et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY (2010)

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Article Oncology

Tissue factor mediates the HGF/Met-induced anti-apoptotic pathway in DAOY medulloblastoma cells

Mathieu Provencal et al.

JOURNAL OF NEURO-ONCOLOGY (2010)

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Article Oncology

Vascular Endothelial Growth Factor Is a Promising Therapeutic Target for the Treatment of Clear Cell Carcinoma of the Ovary

Seiji Mabuchi et al.

MOLECULAR CANCER THERAPEUTICS (2010)

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Article Biochemistry & Molecular Biology

Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes

K. Yamaguchi et al.

ONCOGENE (2010)

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Article Oncology

Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells

N. Yokota et al.

BRITISH JOURNAL OF CANCER (2009)

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Article Oncology

Activity of 2 methoxyestradiol (Panzem® NCD) in advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: A Hoosier Oncology Group trial

Daniela Matei et al.

GYNECOLOGIC ONCOLOGY (2009)

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Article Oncology

Risk of bleeding with vascular endothelial growth factor receptor tyrosine-kinase inhibitors sunitinib and sorafenib: a systematic review and meta-analysis of clinical trials

Youjin Je et al.

LANCET ONCOLOGY (2009)

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Article Endocrinology & Metabolism

Endometriosis and tissue factor

Graciela Krikun et al.

ASSESSMENT OF HUMAN REPRODUCTIVE FUNCTION (2008)

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Article Hematology

Development and validation of a predictive model for chemotherapy-associated thrombosis

Alok A. Khorana et al.

BLOOD (2008)

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Article Oncology

Potential benefit of Sunitinib in recurrent and refractory ovarian clear cell adenocarcinoma

J. A. Rauh-Hain et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2008)

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Article Oncology

Incidence of venous thromboembolism in patients with ovarian cancer undergoing Platinum/Paclitaxel containing first-line chemotherapy: An exploratory analysis by the arbeitsgemeinschaft gynaekologische onkologie ovarian cancer study group

Christina Fotopoulou et al.

JOURNAL OF CLINICAL ONCOLOGY (2008)

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Letter Hematology

Plasma tissue factor may be predictive of venous thromboembolism in pancreatic cancer

A. A. Khorana et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2008)

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Review Hematology

Trousseau's syndrome: Multiple definitions and multiple mechanisms

Ajit Varki

BLOOD (2007)

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Article Oncology

Prognostic factors for stage III epithelial ovarian cancer: A Gynecologic Oncology Group Study

William E. Winter et al.

JOURNAL OF CLINICAL ONCOLOGY (2007)

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Article Oncology

Thromboembolic complications in patients with clear cell carcinoma of the ovary

Yusuke Matsuura et al.

GYNECOLOGIC ONCOLOGY (2007)

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Review Pharmacology & Pharmacy

Plasminogen activator inhibitor-1 in vascular thrombosis

Randal J. Westrick et al.

CURRENT DRUG TARGETS (2007)

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Review Oncology

Oncogenes, Trousseau syndrome, and cancer-related changes in the coagulome of mice and humans

Janusz Rak et al.

CANCER RESEARCH (2006)

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Article Oncology

Clear cell carcinoma of the ovary: a retrospective multicentre experience of 254 patients with complete surgical staging

M. Takano et al.

BRITISH JOURNAL OF CANCER (2006)

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Review Oncology

Anti-angiogenic and anti-inflammatory effects of statins:: Relevance to anti-cancer therapy

J Dulak et al.

CURRENT CANCER DRUG TARGETS (2005)

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Article Multidisciplinary Sciences

The MET oncogene drives a genetic programme linking cancer to haemostasis

C Boccaccio et al.

NATURE (2005)

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Article Hematology

Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis

JL Yu et al.

BLOOD (2005)

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Article Medicine, Research & Experimental

Role of AMP-activated protein kinase in mechanism of metformin action

GC Zhou et al.

JOURNAL OF CLINICAL INVESTIGATION (2001)

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Article Hematology

FXa-induced responses in vascular wall cells are PAR-mediated and inhibited by ZK-807834

K McLean et al.

THROMBOSIS RESEARCH (2001)

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