期刊
CANCERS
卷 14, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/cancers14061438
关键词
matrisome; epithelial-mesenchymal transition; stem-like gastric cancer; glycosaminoglycan biosynthesis-chondroitin sulfate; extracellular matrix
类别
资金
- KHIDI - Ministry of Health and Welfare, Republic of Korea [HI14C1324]
Our study suggests a correlation between the high-matrisome group and stem-like phenotype in gastric cancer. We found that glycosaminoglycan biosynthesis-chondroitin sulfate metabolic reprogramming is associated with poor prognosis. These findings provide a possibility for precision medicine in anticancer therapies.
Simple Summary Our results suggested a correlation between the metabolic reprogramming associated with the high-matrisome group and stem-like phenotype in gastric cancer. Carbohydrate sulfotransferase 7 was found to be associated with the signaling transduction of overexpressed oncogenes and tumor suppressor genes in the high-matrisome group. The high expression of glycosaminoglycan biosynthesis-chondroitin sulfate metabolic pathway genes was associated with poor prognosis. The extracellular matrix (ECM) is an important regulator of all cellular functions, and the matrisome represents a major component of the tumor microenvironment. The matrisome is an essential component comprising genes encoding ECM glycoproteins, collagens, and proteoglycans; however, its role in cancer progression and the development of stem-like molecular subtypes in gastric cancer is unknown. We analyzed gastric cancer data from five molecular subtypes (n = 497) and found that metabolic reprograming differs based on the state of the matrisome. Approximately 95% of stem-like cancer type samples of gastric cancer were in the high-matrisome category, and energy metabolism was considerably increased in the high-matrisome group. Particularly, high glycosaminoglycan biosynthesis-chondroitin sulfate metabolic reprograming was associated with an unfavorable prognosis. Glycosaminoglycan biosynthesis-chondroitin sulfate metabolic reprograming may occur according to the matrisome status and contribute to the development of stem-like phenotypes. Our analysis suggests the possibility of precision medicine for anticancer therapies.
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