4.6 Article

Regulation of Let-7a-5p and miR-199a-5p Expression by Akt1 Modulates Prostate Cancer Epithelial-to-Mesenchymal Transition via the Transforming Growth Factor-beta Pathway

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Review Oncology

Regulatory effects of lncRNAs and miRNAs on the crosstalk between autophagy and EMT in cancer: a new era for cancer treatment

Lihui Si et al.

Summary: Autophagy and EMT are two critical biological processes during cancer development. The crosstalk between autophagy and EMT is complex and plays a crucial role in cancer. Recent research has shown that lncRNAs and miRNAs are involved in the regulation of autophagy, EMT, and their interactions. Understanding the regulatory mechanisms of lncRNAs and miRNAs in cancer is important for diagnosis, prognosis, and therapy.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2022)

Article Biochemistry & Molecular Biology

Bioinformatics Prediction and Analysis of MicroRNAs and Their Targets as Biomarkers for Prostate Cancer: A Preliminary Study

Chipampe Patricia Lombe et al.

Summary: Prostate cancer is the second most common cancer in men globally, with heterogeneous presentations requiring the identification of core biomarkers for more precise early detection and treatment. The study suggests that CDKN1A, FOXC1, and BIRC2 may be core genes for prostate cancer.

MOLECULAR BIOTECHNOLOGY (2022)

Review Andrology

Beyond Prostate Specific Antigen: New Prostate Cancer Screening Options

Tushar Aditya Narain et al.

Summary: PSA is a well-known biomarker used for screening, diagnosis, and follow-up of prostate cancer patients. Due to its limitations, newer blood and urinary biomarkers have been evaluated to improve detection and risk stratification. A combination of these markers, clinical risk factors, and advances in imaging offer the potential for better diagnostic performance and clearer risk stratification to guide therapeutics.

WORLD JOURNAL OF MENS HEALTH (2022)

Review Cell Biology

The amoeboid state as part of the epithelial-to-mesenchymal transition programme

Vittoria Graziani et al.

Summary: This review focuses on the role of amoeboid behavior in cancer cell invasion and metastasis, as well as the molecular biomarkers and physicochemical triggers associated with it. The authors suggest that targeting these characteristics could lead to therapeutic opportunities for cancer treatment.

TRENDS IN CELL BIOLOGY (2022)

Article Genetics & Heredity

Genetic factors associated with prostate cancer conversion from active surveillance to treatment

Yu Jiang et al.

Summary: Men diagnosed with low-risk prostate cancer who initially choose active surveillance may eventually convert to active treatment due to genetic factors that predispose to aggressive tumors. This study identified genetic variants associated with conversion from active surveillance to active treatment, suggesting that germline genetics may help individualize management decisions for low-risk prostate cancer.

HUMAN GENETICS AND GENOMICS ADVANCES (2022)

Review Pharmacology & Pharmacy

Targeting Akt-associated microRNAs for cancer therapeutics

Mir S. Adil et al.

Summary: miRNAs, a subset of non-coding RNAs, play crucial roles in regulating gene expression in various cellular processes, particularly in cell differentiation, proliferation, apoptosis, and tumorigenesis. They can be modulated using techniques such as miRNA mimics or antagonists and hold potential applications in cancer therapy and early diagnosis. Recent evidence suggests that miRNA-mediated gene regulation intersects with the Akt pathway, forming a regulatory network that may greatly impact cancer therapy.

BIOCHEMICAL PHARMACOLOGY (2021)

Review Biochemistry & Molecular Biology

The Role of TGF-β in Bone Metastases

Trupti Trivedi et al.

Summary: This article discusses the significant role of TGF-beta in cancer progression and bone metastases, as well as current perspectives on the therapeutic potential of targeting TGF-beta pathways.

BIOMOLECULES (2021)

Article Oncology

Regulation of Nuclear Factor-KappaB (NF-kB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?

Sepideh Mirzaei et al.

Summary: The NF-xB signaling pathway is a potential therapeutic target in cancer therapy, with its dysregulation impacting cancer cell proliferation, metastasis, and resistance to radiotherapy and chemotherapy. Non-coding RNAs, such as miRNAs, lncRNAs, and circRNAs, play a crucial role in modulating NF-xB signaling and may affect cancer progression by regulating miRNAs targeting NF-xB activation.

CANCER LETTERS (2021)

Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Review Pharmacology & Pharmacy

The unconventional role of Akt1 in the advanced cancers and in diabetes-promoted carcinogenesis

Abdulrahman Alwhaibi et al.

PHARMACOLOGICAL RESEARCH (2019)

Review Cell Biology

The role of microRNAs in prostate cancer migration, invasion, and metastasis

Shirin Golabi Aghdam et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Review Urology & Nephrology

The incidence, mortality, and risk factors of prostate cancer in Asian men

Byung Ha Chung et al.

PROSTATE INTERNATIONAL (2019)

Review Biochemistry & Molecular Biology

MicroRNA Control of TGF-β Signaling

Hiroshi I. Suzuki

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Cell Biology

Isoform-specific effects of transforming growth factor on endothelial-to-mesenchymal transition

Harika Sabbineni et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Review Pharmacology & Pharmacy

EMT: Mechanisms and therapeutic implications

Mohini Singh et al.

PHARMACOLOGY & THERAPEUTICS (2018)

Review Endocrinology & Metabolism

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

Jacob O'Brien et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Review Oncology

Targeting TGF-β Signaling in Cancer

Selcuk Colak et al.

TRENDS IN CANCER (2017)

Review Medicine, General & Internal

Genetic predisposition to prostate cancer

S. Benafif et al.

BRITISH MEDICAL BULLETIN (2016)

Review Biochemistry & Molecular Biology

MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions

Caterina Catalanotto et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Review Multidisciplinary Sciences

Metastasis as an evolutionary process

Samra Turajlic et al.

SCIENCE (2016)

Review Oncology

MicroRNAs and epithelial-mesenchymal transition in prostate cancer

Kirandeep Sekhon et al.

ONCOTARGET (2016)

Review Pharmacology & Pharmacy

An overview of microRNAs

Scott M. Hammond

ADVANCED DRUG DELIVERY REVIEWS (2015)

Article Biochemistry & Molecular Biology

P21 activated kinase-1 mediates transforming growth factor β1-induced prostate cancer cell epithelial to mesenchymal transition

Ahmad Al-Azayzih et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2015)

Review Pharmacology & Pharmacy

Cancer metastases: challenges and opportunities

Xiangming Guan

ACTA PHARMACEUTICA SINICA B (2015)

Article Cell Biology

FOXO1 regulates expression of a microRNA cluster on X chromosome

Ruchi Singhal et al.

AGING-US (2013)

Review Oncology

Regulatory networks defining EMT during cancer initiation and progression

Bram De Craene et al.

NATURE REVIEWS CANCER (2013)

Article Biochemistry & Molecular Biology

TGFβ1 induces apoptosis in invasive prostate cancer and bladder cancer cells via Akt-independent, p38 MAPK and JNK/SAPK-mediated activation of caspases

Ahmad Al-Azayzih et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

Article Oncology

Integrative Genomic Profiling of Human Prostate Cancer

Barry S. Taylor et al.

CANCER CELL (2010)

Review Oncology

Mechanisms of the epithelial-mesenchymal transition by TGF-beta

Michael K. Wendt et al.

FUTURE ONCOLOGY (2009)

Article Biochemistry & Molecular Biology

MicroRNAs Differentially Regulated by Akt Isoforms Control EMT and Stem Cell Renewal in Cancer Cells

Dimitrios Iliopoulos et al.

SCIENCE SIGNALING (2009)

Review Oncology

MicroRNAs - the micro steering wheel of tumour metastases

Milena S. Nicoloso et al.

NATURE REVIEWS CANCER (2009)

Review Biochemistry & Molecular Biology

TGFβ in cancer

Joan Massague

Article Oncology

MicroRNA expression profiling in prostate cancer

Kati P. Porkka et al.

CANCER RESEARCH (2007)

Article Cell Biology

The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice

Mei-Ling Chen et al.

GENES & DEVELOPMENT (2006)