Components of the Lectin Pathway of Complement in Solid Tumour Cancers

Simple Summary Cancer is a major cause of human deaths. The complement system is an important branch of the innate immune response that can be activated via three distinct pathways (classical, alternative, lectin). Complement activation may contribute to cancer prevention, but on the other hand, its over- or chronic activation can be harmful for the host. In this short review, we discuss the dual role of the lectin pathway of complement activation in human solid cancers, including those of the female reproductive system, lung, and alimentary tract, with emphasis on its cross-talk with other enzyme-dependent cascades. The complement system is an important branch of the humoral innate immune response that can be activated via three distinct pathways (classical, alternative, lectin), contributing to keeping/restoring homeostasis. It can also interact with cellular innate immunity and with components of acquired immunity. Cross-talk between the complement system and other enzyme-dependent cascades makes it a more influential defence system, but on the other hand, over- or chronic activation can be harmful. This short review is focused on the dual role of the lectin pathway of complement activation in human solid tumour cancers, including those of the female reproductive system, lung, and alimentary tract, with emphasis on the aforementioned cross-talk.

Automated summary

The complement system is a crucial branch of the innate immune response that can be activated through three distinct pathways. It plays a role in maintaining/restoring homeostasis, interacting with cellular and acquired immunity components. The cross-talk between the complement system and other enzyme-dependent cascades enhances its defensive capabilities, but excessive or chronic activation may be harmful.