期刊
JOURNAL OF CLINICAL MEDICINE
卷 11, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/jcm11071785
关键词
corneal collagen cross-linking; keratoconus; epi-on technique; epi-off technique; iontophoresis; cornea; pachymetry; thinnest point; CXL; OSDI
This study compared the effectiveness of iontophoresis epi-on and epi-off techniques in corneal collagen cross-linking (CXL) and found that both techniques are valid for mid-term corneal stabilization. The advantage of the iontophoresis epi-off technique lies in a faster imbibing time of the cornea, reducing surgical times and lowering the risk of complications.
Background: Corneal collagen cross-linking (CXL) has become the gold standard for mild and moderate stages to stop the progression of keratoconus. We analyzed some corneal topography indices to compare iontophoresis epi-on and iontophoresis epi-off techniques throughout a two-year follow-up. Methods: A total of 64 eyes of 49 patients who underwent CXL were recruited. In 30 eyes the epi-off technique was performed, whereas the remaining 34 eyes were treated with the epi-on technique. All patients underwent a complete ophthalmologic examination that included CDVA, central and thinnest corneal thickness, Schirmer test I, TBUT test, and the Ocular Surface Disease Index. Results: In both groups, a significant improvement in visual function was recorded. No statistically significant differences between Kmax, Mean K, Flat K, Steep K values were found. Statistically significant differences (p < 0.05) between the epi-on and epi-off groups' pachymetry before and after 24 months follow-up as well as between the epi-on and epi-off groups' topographically thinnest point in the immediate post-surgery and 24 months after surgery were recorded. Conclusion: Our study highlighted that both techniques are valid in mid-term corneal stabilization. The advantage of the new iontophoresis epi-off cross-linking technique could be found in a faster imbibing time of the cornea, therefore reducing surgical times, with a lower risk of complications.
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