期刊
JOURNAL OF CLINICAL MEDICINE
卷 11, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/jcm11102876
关键词
body mass index; the residual method; chronic kidney disease; estimated glomerular filtration rate; obesity; waist circumference; waist-to-hip ratio; waist-to-height ratio; waist-to-height(0.5) ratio
资金
- Korea Centers for Disease Control and Prevention [2004-E71004-00, 2005-E71013-00, 2006-E71002-00, 2007-E71002-00, 2007-E71013-00, 2008-E71004-00, 2009-E71006-00, 2010-E71003-00, 2011-E71002-00, 2012-E71007-00, 2013-E71008-00]
This study investigated the associations between waist circumference-related obesity metrics and estimated glomerular filtration rates. The results showed significant associations between most obesity metrics and estimated glomerular filtration rates, especially in women.
Studies that have assessed the associations between obesity and the estimated glomerular filtration rate (eGFR) have reported inconsistent results. This cross-sectional study was performed to investigate the associations between three waist circumference (WC)-related obesity metrics (waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), and waist-to-height(0.5) ratio (WHt.5R)) and eGFRs. This study included 2133 men and 3443 women who were older than 40 years with eGFRs similar to 60 mL/min/1.73 m(2) from the Korean Multi-Rural Communities Cohort. We calculated the residual body mass index (BMI) to reduce multicollinearity among the obesity metrics and performed multiple linear regression. For both sexes, among the adjusted models, most of the general obesity metrics were significantly associated with eGFRs. Particularly for women, the WC-related and general obesity metrics had a stronger effect on eGFRs in the quartile models that included the BMI and the residual BMI, respectively. When WC-related obesity metrics had a stronger effect than the general obesity metric, for both sexes, WHtR showed a significant impact than WHt.5R and WHR on eGFRs. Reducing multicollinearity had an important role in assessing the obesity metrics' association with eGFRs. Overall, applying the residual method in further studies might help with evaluating the obesity paradox on renal function.
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