期刊
JOURNAL OF CLINICAL MEDICINE
卷 11, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/jcm11082206
关键词
type 2 diabetes mellitus; bone fragility; fracture risk; bone structure; bone quality
资金
- Instituto de Salud Carlos III [CD20/00022]
- European Regional Development Fund (FEDER)
- Junta de Andalucia grant [PI-0268-2019]
Bone fragility is a common complication in subjects with type 2 diabetes mellitus. Traditional techniques for evaluating bone fragility do not perform well in this population, but new technologies and biomarkers are emerging as potential solutions.
Bone fragility is a common complication in subjects with type 2 diabetes mellitus (T2DM). However, traditional techniques for the evaluation of bone fragility, such as dual-energy X-ray absorptiometry (DXA), do not perform well in this population. Moreover, the Fracture Risk Assessment Tool (FRAX) usually underestimates fracture risk in T2DM. Importantly, novel technologies for the assessment of one microarchitecture in patients with T2DM, such as the trabecular bone score (TBS), high-resolution peripheral quantitative computed tomography (HR-pQCT), and microindentation, are emerging. Furthermore, different serum and urine bone biomarkers may also be useful for the evaluation of bone quality in T2DM. Hence, in this article, we summarize the limitations of conventional tools for the evaluation of bone fragility and review the current evidence on novel approaches for the assessment of quality and bone microstructure alterations in patients with T2DM.
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