期刊
JOURNAL OF BONE AND MINERAL METABOLISM
卷 35, 期 3, 页码 255-264出版社
SPRINGER JAPAN KK
DOI: 10.1007/s00774-016-0757-8
关键词
MicroRNA; Bone fracture; Osteoblastogenesis; Wwp1
资金
- China: Specialized Research Fund for the Doctoral Program of High Education [20110162110038]
- Fundamental Research Funds for the Central Universities of Central South University [2012zzts033]
- National Natural Scientific Foundation [81371955]
MicroRNAs play important roles in regulating bone regeneration and remodeling. However, the pathophysiological roles of microRNAs in bone repair remain unclear. Here we identify a significant upregulation of miR-142-5p correlated with active osteoblastogenesis during the bone healing process. In vitro, miR-142-5p promoted osteoblast activity and matrix mineralization by targeting the gene encoding WW-domain-containing E3 ubiquitin protein ligase 1. We also found that the expression of miR-142-5p in the callus of aged mice was lower than that in the callus of young mice and directly correlated with the age-related delay in bone healing. Furthermore, treatment with agomir-142-5p in the fracture areas stimulated osteoblast activity which repaired the bone fractures in aged mice. Thus, our study revealed that miR-142-5p plays a crucial role in healing fractures by maintaining osteoblast activity, and provided a new molecular target therapeutic strategy for bone healing.
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