4.7 Review

General Purpose Pharmacokinetic-Pharmacodynamic Models for Target-Controlled Infusion of Anaesthetic Drugs: A Narrative Review

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Review Anesthesiology

Allometric Scaling in Pharmacokinetic Studies in Anesthesiology

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Summary: This article presents a clinical review of basic allometric scaling theory and its application to pharmacokinetic models in anesthesia and other fields in the biologic sciences.

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Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics

Ricardo Alvarez-Jimenez et al.

Summary: This study developed a nonlinear three-compartment pharmacokinetic model that accurately described dexmedetomidine plasma concentrations. Simulations showed that currently approved dosing regimens in the intensive care unit may potentially lead to higher-than-expected dexmedetomidine plasma concentrations.

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Prospective clinical validation of the Eleveld propofol pharmacokinetic-pharmacodynamic model in general anaesthesia

Remco Vellinga et al.

Summary: The Eleveld propofol PK-PD model was prospectively validated in children, adults, older subjects, and obese adults undergoing general anaesthesia. The results showed high predictive precision and low bias in arterial plasma concentrations and BIS predictions when used in TCI in clinical anaesthesia practice.

BRITISH JOURNAL OF ANAESTHESIA (2021)

Editorial Material Medicine, General & Internal

Comment on Morse et al. A Universal Pharmacokinetic Model for Dexmedetomidine in Children and Adults. J. Clin. Med. 2020, 9, 3480

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Target-controlled-infusion models for remifentanil dosing consistent with approved recommendations

Douglas J. Eleveld et al.

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Article Medicine, General & Internal

A Universal Pharmacokinetic Model for Dexmedetomidine in Children and Adults

James D. Morse et al.

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Dexmedetomidine metabolic clearance is not affected by fat mass in obese patients

A. Rolle et al.

BRITISH JOURNAL OF ANAESTHESIA (2018)

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Pharmacokinetic-pharmacodynamic model for propofol for broad application in anaesthesia and sedation

D. J. Eleveld et al.

BRITISH JOURNAL OF ANAESTHESIA (2018)

Article Pharmacology & Pharmacy

Pharmacokinetics and pharmacodynamics of dexmedetomidine-induced vasoconstriction in healthy volunteers

Pekka Talke et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2018)

Article Anesthesiology

Dexmedetomidine pharmacodynamics in healthy volunteers: 2. Haemodynamic profile

P. J. Colin et al.

BRITISH JOURNAL OF ANAESTHESIA (2017)

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An Allometric Model of Remifentanil Pharmacokinetics and Pharmacodynamics

Douglas J. Eleveld et al.

ANESTHESIOLOGY (2017)

Review Anesthesiology

Target-Controlled Infusion: A Mature Technology

Anthony R. Absalom et al.

ANESTHESIA AND ANALGESIA (2016)

Review Anesthesiology

The Safety of Target-Controlled Infusions

Thomas W. Schnider et al.

ANESTHESIA AND ANALGESIA (2016)

Review Anesthesiology

The History of Target-Controlled Infusion

Michel M. R. F. Struys et al.

ANESTHESIA AND ANALGESIA (2016)

Review Anesthesiology

Model-based drug administration: current status of target-controlled infusion and closed-loop control

Merel H. Kuizenga et al.

CURRENT OPINION IN ANESTHESIOLOGY (2016)

Article Pharmacology & Pharmacy

Dexmedetomidine pharmacokinetics in the obese

Luis I. Cortinez et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2015)

Article Anesthesiology

A General Purpose Pharmacokinetic Model for Propofol

Douglas J. Eleveld et al.

ANESTHESIA AND ANALGESIA (2014)

Article Anesthesiology

Performance evaluation of paediatric propofol pharmacokinetic models in healthy young children

P. Sepulveda et al.

BRITISH JOURNAL OF ANAESTHESIA (2011)

Article Anesthesiology

Influence of obesity on propofol pharmacokinetics: derivation of a pharmacokinetic model

L. I. Cortinez et al.

BRITISH JOURNAL OF ANAESTHESIA (2010)

Review Anesthesiology

Pharmacokinetic models for propofol-defining and illuminating the devil in the detail

A. R. Absalom et al.

BRITISH JOURNAL OF ANAESTHESIA (2009)

Review Anesthesiology

Data sharing for pharmacokinetic studies

Brian J. Anderson et al.

PEDIATRIC ANESTHESIA (2009)

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Dexmedetomidine disposition in children: a population analysis

Amanda L. Potts et al.

PEDIATRIC ANESTHESIA (2008)

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'Paedfusor' pharmacokinetic data set

A Absalom et al.

BRITISH JOURNAL OF ANAESTHESIA (2005)

Article Anesthesiology

Using front-end kinetics to optimize target-controlled drug infusions

MJ Avram et al.

ANESTHESIOLOGY (2003)