期刊
JOURNAL OF CLINICAL MEDICINE
卷 11, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/jcm11113173
关键词
urinary galactose-deficient IgA1; KM55; IgA nephropathy
资金
- JSPS KAKENHI [15K09274, 18K08252]
- Practical Research Project for Renal Diseases from the Japan Agency for Medical Research and Development, AMED
- Grants-in-Aid for Scientific Research [15K09274, 18K08252] Funding Source: KAKEN
In patients with IgA nephropathy (IgAN), urinary Gd-IgA1 levels are higher and correlated with disease severity. Urinary Gd-IgA1 can also be detected in early stages of the disease. Therefore, urinary Gd-IgA1 may serve as a useful disease-specific biomarker.
In patients with IgA nephropathy (IgAN), circulatory IgA1 and IgA1 in the mesangial deposits contain galactose-deficient IgA1 (Gd-IgA1). Some of the Gd-IgA1 from the glomerular deposits is excreted in the urine and thus urinary Gd-IgA1 may represent a disease-specific marker. We recruited 338 Japanese biopsy-proven IgAN patients and 120 patients with other renal diseases (disease controls). Urine samples collected at the time of renal biopsy were used to measure Gd-IgA1 levels using a specific monoclonal antibody (KM55 mAb). Urinary Gd-IgA1 levels were significantly higher in patients with IgAN than in disease controls. Moreover, urinary Gd-IgA1 was significantly correlated with the severity of the histopathological parameters in IgAN patients. Next, we validated the use of urinary Gd-IgA1 levels in the other Asian cohorts. In the Korean cohort, urinary Gd-IgA1 levels were also higher in patients with IgAN than in disease controls. Even in Japanese patients with IgAN and trace proteinuria (less than 0.3 g/gCr), urinary Gd-IgA1 was detected. Thus, urinary Gd-IgA1 may be an early disease-specific biomarker useful for determining the disease activity of IgAN.
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