Effects of Higher Normal Blood Pressure on Brain Are Detectable before Middle-Age and Differ by Sex

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Interactions Between Age, Sex, Menopause, and Brain Structure at Midlife: A UK Biobank Study

Stephanie Than et al.

Summary: The study found significant interactions between age and sex or menopausal status among middle-aged women, which play an important role in explaining the MRI biomarkers of dementia.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

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Article Peripheral Vascular Disease

The Association of Age at Diagnosis of Hypertension With Brain Structure and Incident Dementia in the UK Biobank

Xianwen Shang et al.

Summary: This study found that individuals diagnosed with hypertension at younger ages had smaller brain volumes, particularly in gray matter, and were at an increased risk of developing dementia, compared to those diagnosed at older ages.

HYPERTENSION (2021)

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Article Neurosciences

Associations Between Brain Volumes and Cognitive Tests with Hypertensive Burden in UK Biobank

Danielle Newby et al.

Summary: Mid-life hypertension is associated with poorer brain and cognitive health, with the impact of duration of hypertension requiring further investigation. Multiple measures defining hypertension and analysis on hypertension duration provide valuable insights for future research, surpassing prior analyses in the UK Biobank.

JOURNAL OF ALZHEIMERS DISEASE (2021)

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Review Medicine, General & Internal

Higher Blood Pressure is Associated with Greater White Matter Lesions and Brain Atrophy: A Systematic Review with Meta-Analysis

Khawlah Alateeq et al.

Summary: The study found a positive correlation between high blood pressure and poorer brain health, with increases in systolic blood pressure associated with increases in white matter lesions and decreases in hippocampal volume.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Psychology, Biological

Age-related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review

Benjamin Zimmerman et al.

Summary: As people age, physiological changes in the cerebral vascular system can affect cognitive function, and adopting healthy lifestyle habits such as regular exercise and a balanced diet may lead to improved cognitive outcomes.

PSYCHOPHYSIOLOGY (2021)

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Article Peripheral Vascular Disease

Blood Pressure Determinants of Cerebral White Matter Hyperintensities and Microstructural Injury: UK Biobank Cohort Study

Karolina A. Wartolowska et al.

Summary: Small vessel disease, stroke, and dementia risks are associated with aging and hypertension, but it is uncertain whether pulsatile or steady blood pressure plays a more critical role in the development of brain white matter damage. This study found that both components of blood pressure were linked to white matter injury, with pulse pressure (PP) showing a stronger effect. Moreover, the synergistic interaction between PP and age intensified the impact of age on white matter damage.

HYPERTENSION (2021)

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Age, menstruation history, and the brain

Ananthan Ambikairajah et al.

Summary: This study investigated the association between measures of menstruation history and brain volume, finding that postmenopausal women had larger total brain and hippocampal volumes compared to premenopausal women. Additionally, early age of menarche, delayed age of menopause, and longer duration of reproductive stage were negatively associated with brain volume. Further research is needed to determine if the negative association between age of menopause and hippocampal volume may indicate future vulnerability to dementia.

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY (2021)

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Article Clinical Neurology

Diastolic Blood Pressure Is Associated With Regional White Matter Lesion Load The Northern Manhattan Study

Michelle R. Caunca et al.

STROKE (2020)

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Sex differences in the association of photoperiod with hippocampal subfield volumes in older adults: A cross-sectional study in the UK Biobank cohort

Naif A. Majrashi et al.

BRAIN AND BEHAVIOR (2020)

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Article Endocrinology & Metabolism

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Ananthan Ambikairajah et al.

OBESITY (2020)

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Article Clinical Neurology

Higher diastolic blood pressure aged 40‐44 is associated with declining cognition and increasing white matter lesions over 8‐12 year follow up.

Ruth Peters et al.

Alzheimers & Dementia (2020)

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Article Clinical Neurology

Association of peripheral blood pressure with gray matter volume in 19-to 40-year-old adults

H. Lina Schaare et al.

NEUROLOGY (2019)

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Review Clinical Neurology

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Luciana A. Pescatore et al.

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Review Neurosciences

Midlife Hypertension and Alzheimer's Disease: A Systematic Review and Meta-Analysis

Matthew J. Lennon et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

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Article Clinical Neurology

Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study

Christopher A. Lane et al.

LANCET NEUROLOGY (2019)

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Article Neuroimaging

Hippocampal vascularization patterns: A high-resolution 7 Tesla time-of-flight magnetic resonance angiography study

Spallazzi Marco et al.

NEUROIMAGE-CLINICAL (2019)

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Review Peripheral Vascular Disease

Could Management of Blood Pressure Prevent Dementia in the elderly?

Masaki Mogi

CLINICAL HYPERTENSION (2019)

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Article Endocrinology & Metabolism

Body mass index is associated with cortical thinning with different patterns in mid- and late-life

M. E. Shaw et al.

INTERNATIONAL JOURNAL OF OBESITY (2018)

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Article Cardiac & Cardiovascular Systems

2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/N MA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank

Fidel Alfaro-Almagro et al.

NEUROIMAGE (2018)

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Association of Cardiovascular Risk Factors With MRI Indices of Cerebrovascular Structure and Function and White Matter Hyperintensities in Young Adults

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

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NATURE NEUROSCIENCE (2016)

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Article Geriatrics & Gerontology

Prehypertension in midlife is associated with worse cognition a decade later in middle-aged and older women

Karren H. M. Chen et al.

AGE AND AGEING (2015)

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Article Endocrinology & Metabolism

Being overweight is associated with hippocampal atrophy: the PATH Through Life Study

N. Cherbuin et al.

INTERNATIONAL JOURNAL OF OBESITY (2015)

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Article Peripheral Vascular Disease

Blood Pressure, Brain Structure, and Cognition: Opposite Associations in Men and Women

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AMERICAN JOURNAL OF HYPERTENSION (2015)

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Article Clinical Neurology

Joint effect of mid- and late-life blood pressure on the brain The AGES-Reykjavik Study

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NEUROLOGY (2014)

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Cardiovascular Disease Risk Models and Longitudinal Changes in Cognition: A Systematic Review

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PLOS ONE (2014)

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Midlife Blood Pressure, Plasma β-Amyloid, and the Risk for Alzheimer Disease The Honolulu Asia Aging Study

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Dementia and Alzheimer's disease incidence in relationship to cardiovascular disease in the cardiovascular health study cohort

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A hybrid approach to the skull stripping problem in MRI

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Effects of Higher Normal Blood Pressure on Brain Are Detectable before Middle-Age and Differ by Sex

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