4.7 Article

Waning immune responses against SARS-CoV-2 variants of concern among vaccinees in Hong Kong

期刊

EBIOMEDICINE
卷 77, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.ebiom.2022.103904

关键词

SARS-CoV-2; mRNA vaccine; Inactivated vaccine; Cellular immune response; Humoral immune response

资金

  1. Hong Kong Research Grants Council Collaborative Research Fund [C715620GF, C1134-20GF]
  2. Wellcome Trust [P86433]
  3. National Program on Key Research Project of China [2020YFC0860600, 2020YFA0707500, 2020YFA0707504]
  4. Shenzhen Science and Technology Program [JSGG20200225151410198, JCYJ20210324131610027]
  5. HKU Development Fund
  6. LKS Faculty of Medicine Matching Fund
  7. Hong Kong Innovation and Technology Fund
  8. Theme-Based Research Scheme [T11-706/18-N]
  9. Innovation and Technology Commission

向作者/读者索取更多资源

This study compares the immunogenicity and durability of BNT162b2-mRNA and CoronaVac-inactivated vaccines in fully vaccinated individuals in Hong Kong. The results show that both vaccines induce neutralizing antibodies and spike-specific CD4 T cell responses, but CoronaVac vaccine induces lower immune responses compared to BNT162b2 vaccine. Against SARS-CoV-2 variants of concern, CoronaVac vaccine shows weaker neutralizing antibody responses compared to BNT162b2 vaccine. Three months after vaccination, neutralizing antibody levels to variants of concern decrease, along with waning memory T cell responses, especially among CoronaVac vaccine recipients.
Background Nearly 4 billion doses of the BNT162b2-mRNA and CoronaVac-inactivated vaccines have been administrated globally, yet different vaccine-induced immunity against SARS-CoV-2 variants of concern (VOCs) remain incompletely investigated.& nbsp;Methods We compare the immunogenicity and durability of these two vaccines among fully vaccinated Hong Kong people.& nbsp;Findings Standard BNT162b2 and CoronaVac vaccinations were tolerated and induced neutralizing antibody (NAb) (100% and 85.7%) and spike-specific CD4 T cell responses (96.7% and 82.1%), respectively. The geometric mean NAb IC50 and median frequencies of reactive CD4 subsets were consistently lower among CoronaVac-vaccinees than BNT162b2-vaccinees. CoronaVac did not induce measurable levels of nucleocapsid protein-specific IFN-(+)(gamma) CD4+ T or IFN-(+)(gamma) CD8(+) T cells compared with unvaccinated. Against VOCs, NAb response rates and geometric mean IC50 titers against B.1.617.2 (Delta) and B.1.1.529 (Omicron) were significantly lower for CoronaVac (50%, 23.2 and 7.1%, < 20) than BNT162b2 (94.1%, 131 and 58.8%, 35.0), respectively. Three months after vaccinations, NAbs to VOCs dropped near to detection limit, along with waning memory T cell responses, mainly among CoronaVac-vaccinees.& nbsp;Interpretation Our results indicate that vaccinees especially CoronaVac-vaccinees with significantly reduced NAbs may probably face higher risk to pandemic VOCs breakthrough infection. Copyright (C)& nbsp;2022 The Authors. Published by Elsevier B.V.

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