期刊
EBIOMEDICINE
卷 78, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ebiom.2022.103978
关键词
Telomeres; T-cells; COVID-19; SARS-CoV-2; Ageing; Vaccines
资金
- NIH [RF1AG046860, 5U24AG066528, 1R56AG073226-01, U01AG066529]
- Research Council of Norway [262700]
The decline in T-cell clonal expansion capacity is closely related to the increase in COVID-19 mortality with age. Older adults and younger individuals with inherently short HCTL are more vulnerable to COVID-19 T-cell lymphopenia and severe disease.
Background Severe COVID-19 T-cell lymphopenia is more common among older adults and entails poor prognosis. Offsetting the decline in T-cell count during COVID-19 demands fast and massive T-cell clonal expansion, which is telomere length (TL)-dependent. Methods We developed a model of TL-dependent T-cell clonal expansion capacity with age and virtually examined the relation of T-cell clonal expansion with COVID-19 mortality in the general population. Findings The model shows that an individual with average hematopoietic cell TL (HCTL) at age twenty years maintains maximal T-cell clonal expansion capacity until the 6th decade of life when this capacity rapidly declines by more than 90% over the next ten years. The collapse in the T-cell clonal expansion capacity coincides with the steep increase in COVID-19 mortality with age. Interpretation Short HCTL might increase vulnerability of many older adults, and some younger individuals with inherently short HCTL, to COVID-19 T-cell lymphopenia and severe disease. Copyright (C) 2022 The Author(s). Published by Elsevier B.V.
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