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Article
Pharmacology & Pharmacy
Rana Abdelnabi et al.
Summary: The infectivity of the omicron variant in hamsters was found to be lower than that of the ancestral D614G strain, with a significant decrease in viral RNA load in the lungs and no detectable infectious virus in this organ. Histopathological examination of the lungs from omicron-infected hamsters revealed no signs of peri-bronchial inflammation or bronchopneumonia.
ANTIVIRAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Juan Manuel Carreno et al.
Summary: The Omicron variant of SARS-CoV-2, first identified in South Africa and Botswana in November 2021, has rapidly spread globally with high transmissibility. It has an unprecedented number of mutations in its spike gene, leading to immune escape and reduced vaccine efficacy. The neutralizing and binding activity against Omicron varies among individuals with different vaccination and infection histories.
Article
Multidisciplinary Sciences
Huiping Shuai et al.
Summary: The Omicron variant of SARS-CoV-2 shows reduced replication ability in human cells and attenuated pathogenicity in mice compared with the wild-type strain and other variants. It has lower efficiency in using TMPRSS2 and causes the lowest reduction in body weight and mortality rate among the tested strains.
Article
Multidisciplinary Sciences
Rigel Suzuki et al.
Summary: The Omicron variant of SARS-CoV-2 has spread rapidly in several countries and has shown lower fusogenicity and attenuated pathogenicity compared to the Delta variant.
Article
Multidisciplinary Sciences
Peter J. Halfmann et al.
Summary: The recent study by the SAVE/NIAID network shows that the B.1.1.529 Omicron variant causes milder lung disease in rodents, which is consistent with preliminary human clinical data.
Letter
Medicine, General & Internal
Annika Roessler et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Letter
Medicine, General & Internal
Fabian Schmidt et al.
Summary: Neutralization assays showed much lower omicron neutralization compared to Wuhan-hu-1 after two doses of mRNA vaccine, but individuals who received a booster vaccine or were vaccinated after recovering from Covid-19 exhibited high levels of omicron neutralization.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Virology
Sreelekshmy Mohandas et al.
Summary: The SARS-CoV-2 Delta variant has distinct disease characteristics and reinfection potential compared to other variants. Prior infection can increase neutralizing antibody levels and reduce disease severity.
Article
Virology
Pragya D. Yadav et al.
Summary: Due to the failure of virus isolation in Vero CCL-81 cells, an in vivo and subsequent in vitro approach were used to isolate the Omicron variant. The virus was successfully isolated from hamster specimens and showed high viral load and cytopathic effects in infected cells. Genome analysis revealed mutations in different host species.
Article
Biology
Bobo Wing-Yee Mok et al.
Summary: The study found that the Alpha variant of SARS-CoV-2 has increased competitive fitness in a hamster model, replicating and shedding more efficiently in the nasal cavity, which may contribute to its rapid transmission. These results help explain why emerging variants of the virus are more efficient in spreading.
COMMUNICATIONS BIOLOGY
(2021)
Letter
Medicine, General & Internal
Keiya Uriu et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Sreelekshmy Mohandas et al.
Summary: The study demonstrated that the BBV152A and BBV152B vaccine candidates induced quick and robust immune responses, providing protection to Syrian hamsters from lung pathology after SARS-CoV-2 infection.
Article
Virology
Rory D. de Vries et al.
Summary: SARS-CoV-2 originated as a zoonotic virus in China in December 2019, leading to the global COVID-19 pandemic with high morbidity and mortality. Vaccines developed at unprecedented speed have shown efficacy in preventing disease, but their ability to interrupt transmission remains uncertain. Furthermore, concerning virus variants are emerging that may be more transmissible and/or less sensitive to immune responses.
CURRENT OPINION IN VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Jakob Trimpert et al.
Summary: Vaccines play a crucial role in combating the COVID-19 pandemic, with large-scale recoding of the virus genome to create live attenuated vaccine candidates offering cross-neutralizing antibody responses and providing protection against COVID-19-like disease in hamsters.
Article
Immunology
Shu Horiuchi et al.
Summary: The study found that the innate immune response to SARS-CoV-2 infection was delayed but followed by a pronounced adaptive response, with T cell adoptive transfer reducing virus levels and rapidly inducing specific B cells. SARS-CoV-2-specific T and B cells were able to control infection, but failed to prevent transmission to both naive and vaccinated animals.
SCIENCE IMMUNOLOGY
(2021)
Article
Immunology
Rana Abdelnabi et al.
Summary: The emergence of SARS-CoV-2 variants of concern has worsened the COVID-19 pandemic, with current monoclonal antibodies and vaccines showing reduced efficacy against some of these variants. However, antivirals targeting conserved proteins of SARS-CoV-2 are likely to remain effective. Research on molnupiravir has shown effectiveness against different variants, highlighting its potential in combating current and future variants.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Microbiology
William T. Harvey et al.
Summary: The evolution of SARS-CoV-2 has been characterized by the emergence of mutations and variants that impact virus characteristics. Manufacturers are preparing for possible updates to vaccines in response to changes in the virus population, and it is crucial to monitor genetic and antigenic changes alongside experiments to understand the impacts of mutations.
NATURE REVIEWS MICROBIOLOGY
(2021)
Article
Cell Biology
Lisa H. Tostanoski et al.
Summary: This study explored how mutations in spike proteins of different SARS-CoV-2 variants affect natural and vaccine-induced immunity, finding that primary infection with the WA1/2020 strain provided strong protection, while antibodies induced by the Ad26.COV2.S vaccine showed reduced neutralizing activity against the B.1.351 strain but still offered effective protection.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Sreelekshmy Mohandas et al.
Summary: The study demonstrated comparable transmission of both U.K. and D614G variants of SARS-CoV-2 in Syrian hamsters in the given conditions. Provided these data, it seems that all the routes of exposure are effective leading to higher transmission.
VECTOR-BORNE AND ZOONOTIC DISEASES
(2021)
Article
Virology
Sreelekshmy Mohandas et al.
Summary: The B.1.617 lineage, especially the Delta variant, is becoming dominant globally in COVID-19 cases. The Delta variant induced moderate lung disease in about 40% of infected animals, with lower neutralizing antibody responses compared to other variants.
Review
Virology
Ivana Lazarevic et al.
Summary: Although SARS-CoV-2 evolves slowly compared to other RNA viruses, its rapid transmission during the COVID-19 pandemic has led to the emergence of numerous variants, some of which have been labeled as variants of concern. These variants may have an impact on transmission, morbidity/mortality, and evasion of neutralization by antibodies, especially monoclonal antibodies.
Article
Medicine, General & Internal
Rana Abdelnabi et al.
Summary: The global COVID-19 pandemic has resulted in over 108 million infections and 2.4 million deaths within a year, with new variants of concern emerging. Research on prototypic VoC from B.1.1.7 and B.1.351 variants in hamsters revealed efficient infection of the lower respiratory tract and highlighted the need for assessing vaccine and therapeutic efficacy against these variants.
Article
Immunology
Claude Kwe Yinda et al.
Summary: The study demonstrates that aerosol exposure to SARS-CoV-2 is a more efficient route of infection compared to fomite exposure. Previous infection with SARS-CoV-2 lineage A does not prevent heterologous reinfection with B.1.351, but does prevent disease and onward transmission.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Biochemical Research Methods
Anita Shete et al.
Summary: This protocol outlines an indirect enzyme-linked immunosorbent assay for the qualitative detection of IgG antibodies against SARS-CoV-2 in Syrian hamster serum samples. It includes the preparation of inactivated virus antigens, negative control antigens, and the use of antigen-coated microtiter plates. The assay has limited batch-to-batch variability and has been validated with independently prepared antigens.
Article
Multidisciplinary Sciences
Masaki Imai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Immunology
Ranawaka A. P. M. Perera et al.
EMERGING INFECTIOUS DISEASES
(2020)
Letter
Immunology
Sreelekshmy Mohandas et al.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2020)
Letter
Immunology
Manohar Lal Choudhary et al.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2020)
