Troublemaking mutations: Clonal hematopoiesis for the prediction of prognosis in ST-segment elevation myocardial infarction

Article Cardiac & Cardiovascular Systems

Clonal haematopoiesis in chronic ischaemic heart failure: prognostic role of clone size for DNMT3A- and TET2-driver gene mutations

Birgit Assmus et al.

Summary: Somatic mutations of DNMT3A and TET2 in patients with chronic ischaemic heart failure were found to be associated with clonal haematopoiesis and poor prognosis. The study defined threshold levels for these mutations, indicating a worse outcome in patients with higher variant allele frequencies.

EUROPEAN HEART JOURNAL (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Clonal Hematopoiesis and Risk of Progression of Heart Failure With Reduced Left Ventricular Ejection Fraction

Domingo A. Pascual-Figal et al.

Summary: This study found that clonal hematopoiesis mutations are common among HF patients with reduced LVEF and are associated with accelerated HF progression, regardless of whether the etiology is ischemic or nonischemic.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Targeting inflammation in atherosclerosis - from experimental insights to the clinic

Oliver Soehnlein et al.

Summary: Inflammation plays a substantial role in atherosclerosis and targeting inflammatory pathways could provide a promising new avenue to prevent and treat the disease. Clinical studies have shown that modulation of inflammation can help prevent the clinical complications of atherosclerosis. Refining strategies for combatting inflammation in the disease is crucial for further progress in managing atherosclerotic risk.

NATURE REVIEWS DRUG DISCOVERY (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems