4.7 Article

Biological and technical factors in the assessment of blood-based tumor mutational burden (bTMB) in patients with NSCLC

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Liquid biopsy as an option for predictive testing and prognosis in patients with lung cancer

Alvida Qvick et al.

Summary: This study investigates the clinical value of liquid biopsy as a primary source for variant analysis in lung cancer, as well as characterizing liquid biopsy variants and correlating mutational load with clinical data. The results show significantly more variants detected in lung cancer patients compared to controls, and the number of variants in plasma is associated with prognosis in lung cancer.

MOLECULAR MEDICINE (2021)

Review Oncology

The prognostic impact of tumor mutational burden (TMB) in the first-line management of advanced non-oncogene addicted non-small-cell lung cancer (NSCLC): a systematic review and meta-analysis of randomized controlled trials

A. Galvano et al.

Summary: In TMB-high patients, immune-oncology agents showed improved ORR, PFS, and OS compared to standard chemotherapy, suggesting a predictive role of high TMB for IO regimens. However, in TMB-low patients, the IO strategy did not lead to significant survival and activity benefits, with pooled results favoring chemotherapy in terms of ORR and PFS.

ESMO OPEN (2021)

Article Medicine, General & Internal

Atezolizumab for First-Line Treatment of PD-L1-Selected Patients with NSCLC

Roy S. Herbst et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Oncology

Size matters: Dissecting key parameters for panel-based tumor mutational burden analysis

Ivo Buchhalter et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

Article Oncology

Optimizing panel-based tumor mutational burden (TMB) measurement

J. Budczies et al.

ANNALS OF ONCOLOGY (2019)

Editorial Material Respiratory System

Blood-based tumor mutation burden: continued progress toward personalizing immunotherapy in non-small cell lung cancer

Vincent K. Lam et al.

JOURNAL OF THORACIC DISEASE (2019)

Article Medicine, General & Internal

Nivolumab plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer

M. D. Hellmann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden

M. D. Hellmann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

Complication rates of CT-guided transthoracic lung biopsy: meta-analysis

W. J. Heerink et al.

EUROPEAN RADIOLOGY (2017)

Article Medicine, General & Internal

First-Line Nivolumab in Stage IV or Recurrent Non-Small-Cell Lung Cancer

D. P. Carbone et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Genetics & Heredity

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

Zachary R. Chalmers et al.

GENOME MEDICINE (2017)

Article Biotechnology & Applied Microbiology

Integrated digital error suppression for improved detection of circulating tumor DNA

Aaron M. Newman et al.

NATURE BIOTECHNOLOGY (2016)

Article Biochemistry & Molecular Biology

Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity

Michael S. Rooney et al.

Article Medicine, General & Internal

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

D. T. Le et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Review Multidisciplinary Sciences

Neoantigens in cancer immunotherapy

Ton N. Schumacher et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

Naiyer A. Rizvi et al.

SCIENCE (2015)

Article Biochemical Research Methods

FACTERA: a practical method for the discovery of genomic rearrangements at breakpoint resolution

Aaron M. Newman et al.

BIOINFORMATICS (2014)

Article Biochemistry & Molecular Biology

An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage

Aaron M. Newman et al.

NATURE MEDICINE (2014)

Article Cell Biology

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

Chetan Bettegowda et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Editorial Material Genetics & Heredity

The Cancer Genome Atlas Pan-Cancer analysis project

John N. Weinstein et al.

NATURE GENETICS (2013)

Article Medicine, General & Internal

Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer

Julie R. Brahmer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Medicine, General & Internal

Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer

Suzanne L. Topalian et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)