期刊
SCIENCE ADVANCES
卷 8, 期 9, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abj9109
关键词
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资金
- Swiss National Science Foundation (SNSF) [176206, 51NF40-158776, 51NF40-185897]
- ERA-NET (Biostress
- SNSF) [31NE30_189061]
- Biostime Institute for Nutrition and Care-Geneva Funding Programs
- EPFL Fellows Marie SklodowskaCurie actions (MSCA) [6656679]
- EMBO long-term fellowship [ALTF 1537-2015
- ]
- EMBO long-term fellowship [MSCA] [LTFCOFUND2013, GA-2013-609409]
- Eurotech EU Horizon 2020 [754462]
- EPFL
- European Research Council [ERC-AdG-787702]
- SNSF [SNSF 310030B_160318, 31003A_179435]
- NIH [AG041250, CA166590, CA163640]
- Swiss National Science Foundation (SNF) [51NF40-185897, 31NE30_189061] Funding Source: Swiss National Science Foundation (SNF)
Puberty stress can lead to changes in adiposity and social behavior, and the reduced levels of NAMPT in fat tissue contribute to lifelong reductions in sociability induced by stress. Impairments in the NAD(+)/SIRT1 pathway in the nucleus accumbens are implicated in sociability deficits. Normalization of NAMPT levels or treatment with NAD(+) boosters can prevent impairments in sociability and neuronal excitability in the accumbens.
Obesity is frequently associated with impairments in the social domain, and stress at puberty can lead to long-lasting changes in visceral fat deposition and in social behaviors. However, whether stress-induced changes in adipose tissue can affect fat-to-brain signaling, thereby orchestrating behavioral changes, remains unknown. We found that peripubertally stressed male-but not female-mice exhibit concomitant increased adiposity and sociability deficits. We show that reduced levels of the adipokine nicotinamide phosphoribosyltransferase (NAMPT) in fat and its extracellular form eNAMPT in blood contribute to lifelong reductions in sociability induced by peripubertal stress. By using a series of adipose tissue and brain region-specific loss- and gain-of-function approaches, we implicate impaired nicotinamide adenine dinucleotide (NAD(+))/SIRT1 pathway in the nucleus accumbens. Impairments in sociability and accumbal neuronal excitability are prevented by normalization of eNAMPT levels or treatment with nicotinamide mononucleotide (NMN), a NAD(+)-boosting compound. We propose NAD(+) boosters to treat social deficits of early life stress origin.
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