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On vasa vasorum: A history of advances in understanding the vessels of vessels

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SCIENCE ADVANCES
卷 8, 期 16, 页码 -

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AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abl6364

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  1. National Institutes of Health [HL131632]
  2. Commonwealth of PA CURE Program
  3. UPMC Pellegrini Chair in Cardiothoracic Surgery
  4. University of Pittsburgh Physicians
  5. Root Family Fund for Lung Transplantation and Lung Failure Research

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The vasa vasorum are a microvascular network that supports the outer wall of blood vessels, and their importance and impact in vascular health and disease are not fully understood. Recent advances in imaging techniques provide opportunities for understanding cardiovascular diseases and microcirculation diseases.
The vasa vasorum are a vital microvascular network supporting the outer wall of larger blood vessels. Although these dynamic microvessels have been studied for centuries, the importance and impact of their functions in vascular health and disease are not yet fully realized. There is now rich knowledge regarding what local progenitor cell populations comprise and cohabitate with the vasa vasorum and how they might contribute to physiological and pathological changes in the network or its expansion via angiogenesis or vasculogenesis. Evidence of whether vasa vasorum remodeling incites or governs disease progression or is a consequence of cardiovascular pathologies remains limited. Recent advances in vasa vasorum imaging for understanding cardiovascular disease severity and pathophysiology open the door for theranostic opportunities. Approaches that strive to control angiogenesis and vasculogenesis potentiate mitigation of vasa vasorum-mediated contributions to cardiovascular diseases and emerging diseases involving the microcirculation.

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