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Hypothyroidism confers tolerance to cerebral malaria

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An update on non-thyroidal illness syndrome

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Summary: NTIS is a syndrome characterized by changes in serum thyroid hormones concentrations in severe illnesses, particularly a decrease in serum T3 levels, which is correlated with disease severity and outcomes. The role of (parenteral) feeding in critical illness as a major determinant of NTIS and clinical outcome has been recognized in recent years. Studies have shown that tissue thyroid hormone concentrations during NTIS may not correlate with serum levels, highlighting the importance of organ-specific thyroid transporters, receptors, and deiodinases.

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