期刊
SCIENCE ADVANCES
卷 8, 期 11, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abl6015
关键词
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资金
- Bill and Melinda Gates Foundation [INV-002740, INV-006131, INV-027406]
- Koch Institute Support (core) grant from the National Cancer Institute [P30-CA14051]
- Multidisciplinary AIDS Training Program [T32 AI007387]
- Bill and Melinda Gates Foundation [INV-027406, INV-002740, INV-006131] Funding Source: Bill and Melinda Gates Foundation
Authorized vaccines against SARS-CoV-2 are not widely available in low- and middle-income countries due to supply shortages, high costs, and complex storage requirements. However, a new vaccine candidate using widely available, safe adjuvants has shown promising results in animal trials, eliciting protective immunity and demonstrating the potential benefits of a low-cost modular vaccine platform for SARS-CoV-2 and other variants.
Authorized vaccines against SARS-CoV-2 remain less available in low- and middle-income countries due to insufficient supply, high costs, and storage requirements. Global immunity could still benefit from new vaccines using widely available, safe adjuvants, such as alum and protein subunits, suited to low-cost production in existing manufacturing facilities. Here, a clinical-stage vaccine candidate comprising a SARS-CoV-2 receptor binding domain-hepatitis B surface antigen virus-like particle elicited protective immunity in cynomolgus macaques. Titers of neutralizing antibodies (>10(4)) induced by this candidate were above the range of protection for other licensed vaccines in nonhuman primates. Including CpG 1018 did not significantly improve the immunological responses. Vaccinated animals challenged with SARS-CoV-2 showed reduced median viral loads in bronchoalveolar lavage (similar to 3.4 log(10)) and nasal mucosa (similar to 2.9 log(10)) versus sham controls. These data support the potential benefit of this design for a low-cost modular vaccine platform for SARS-CoV-2 and other variants of concern or betacoronaviruses.
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