期刊
MSPHERE
卷 7, 期 2, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/msphere.00941-21
关键词
COVID-19; LED; SARS-CoV-2; aerosols; deep UV
类别
资金
- Ministry of Health, Labour and Welfare of Japan [19HA1003]
- Japan Agency for Medical Research and Development (AMED) [19fk0108113]
- Japan Program for Infectious Diseases Research and Infrastructure from AMED [JP21wm0125002]
- NIAID [HHSN272201400008C]
- Japan Society for the Promotion of Science (JSPS) KAKENHI [20H00348]
- Ministry of Internal Affairs and Communications of Japan
- Grants-in-Aid for Scientific Research [20H00348] Funding Source: KAKEN
A high-power DUV-LED system has been developed, which can effectively inactivate SARS-CoV-2 within a short period of time. The inactivation effect is significantly higher for aerosolized SARS-CoV-2 compared to SARS-CoV-2 suspensions.
We developed a 265-nm high-power DUV-LED irradiation system and quantitatively demonstrated that the DUV-LED can inactivate SARS-CoV-2 in suspensions and aerosols within very short irradiation times. We also found that the inactivation effect was about nine times greater against aerosolized SARS-CoV-2 than against SARS-CoV-2 suspensions. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19) is an acute respiratory infection transmitted by droplets, aerosols, and contact. Controlling the spread of COVID-19 and developing effective decontamination options are urgent issues for the international community. Here, we report the quantitative inactivation of SARS-CoV-2 in liquid and aerosolized samples by a state-of-the-art, high-power, AlGaN-based, single-chip compact deep-UV (DUV) light-emitting diode (LED) that produces a record continuous-wave output power of 500 mW at its peak emission wavelength of 265 nm. Using this DUV-LED, we observed a greater-than-5-log reduction in infectious SARS-CoV-2 in liquid samples within very short irradiation times (<0.4 s). When we quantified the efficacy of the 265-nm DUV-LED in inactivating SARS-CoV-2, we found that DUV-LED inactivation of aerosolized SARS-CoV-2 was approximately nine times greater than that of SARS-CoV-2 suspension. Our data demonstrate that this newly developed, compact, high-power 265-nm DUV-LED irradiation system with remarkably high inactivation efficiency for aerosolized SARS-CoV-2 could be an effective and practical tool for controlling SARS-CoV-2 spread. IMPORTANCE We developed a 265-nm high-power DUV-LED irradiation system and quantitatively demonstrated that the DUV-LED can inactivate SARS-CoV-2 in suspensions and aerosols within very short irradiation times. We also found that the inactivation effect was about nine times greater against aerosolized SARS-CoV-2 than against SARS-CoV-2 suspensions. The DUV-LED has several advantages over conventional LEDs and mercury lamps, including high power, compactness, and environmental friendliness; its rapid inactivation of aerosolized SARS-CoV-2 opens up new possibilities for the practical application of DUV-LEDs in high-efficiency air purification systems to control airborne transmission of SARS-CoV-2.
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