期刊
CHEMISTRYSELECT
卷 7, 期 15, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202104218
关键词
Antitumor agents; Apoptosis; Carboxamide; Centrosome declustering; Nitrofuran
资金
- Higher Education Commission, Pakistan [NRPU-5914]
- LUMS Faculty Initiative Funds [FIF-222, FIF-533]
In this study, a novel compound 5h was identified as an inhibitor of centrosome clustering in breast cancer cells. Treatment with 5h resulted in mitotic arrest and apoptotic cell death.
The fragility of cancer cells at the time of mitosis has served as an important target for the development of many successful chemotherapeutic agents. Many cancers cells have supernumerary centrosomes that they cluster during mitosis to form bipolar spindles. Inhibition of centrosome clustering in these cells results in multipolar spindle formation and apoptotic cell death, providing an opportunity to selectively target a subset of cancers with centrosome amplification. In the current work, we report synthesis of 29 novel tethered biaryls and biological evaluation of their ability to inhibit centrosome clustering in breast cancer cells (BT-549). We have identified N-benzhydryl-5-nitrofuran-2-carboxamide (5 h) as a centrosome declustering compound. 5 h has potent antiproliferative activity in centrosome amplified BT-549 cells with GI(50) value of 1.81 +/- 0.19 mu M (n=2). Treatment of BT-549 cells with 5 h causes centrosome declustering resulting in mitotic arrest due to multipolar spindle formation and misaligned chromosomes which ultimately leads to apoptotic cell death.
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