期刊
CHEMISTRYSELECT
卷 7, 期 12, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202200130
关键词
Aspergillus; butenolides; natural products; receptors; SARS-CoV-2 M-pro
资金
- Scientific and Technological Research Council of Turkey (TUBITAK)
In this study, the potential therapeutic effects of compounds isolated from a marine-derived fungus extract were investigated through experiments on inflammation, allergy, and viral enzyme activity, revealing that two butenolide derivatives showed potential for treatment.
Amid the current COVID-19 pandemic, the emergence of several variants in a relatively high mutation rate (twice per month) strengthened the importance of finding out a chemical entity that can be potential for developing an effective medicine. In this study, we explored ethyl acetate (EtOAc) extract of a marine-derived fungus Aspergillus cosatricaensis afforded three butenolide derivatives, butyrolactones I, VI and V (1-3), two naphtho-gamma-pyrones, TMC-256 A1 (4) and rubrofusarin B (5) and methyl p-hydroxyphenyl acetate (6). Structure identification was unambiguously determined based on exhaustive spectral analyses including 1D/2D NMR and mass spectrometry. The isolated compounds (1-6) were assessed for their in vitro anti-inflammatory, antiallergic, elastase inhibitory activities and in silico SARS-CoV-2 main protease (M-pro). Results exhibited that only butenolides (1 and 2) revealed potent activities similar to or more than reference drugs unlike butyrolactone V (3) suggesting them as plausible chemical entities for developing lead molecules.
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