期刊
CHEMISTRYSELECT
卷 7, 期 21, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202201378
关键词
Chalcone; Cycloaddition; Indolizines; Quinazolinone; Zwitterions
资金
- SERB New Delhi [SRG 2020-00721]
- CSIR, New Delhi
An efficient methodology for the synthesis of indolizines from readily accessible substrates via I-2/FeCl3 is described. This approach provides a highly efficient and convenient way to obtain indolizine derivatives under relatively mild reaction conditions.
The indolizines nucleus is an important element of many synthetic molecules with significant biological activity. An efficient methodology for the synthesis of a variety of indolizines from quinazolinone, pyridine, and chalcone via I-2/FeCl3 has been described. The reaction was promoted through Zwitterion formation/cyclization/aromatization sequence, affording the desired products in moderate to very good yields. This approach is a highly efficient and convenient way to get derivatives of indolizines from readily accessible substrate under relatively mild reaction conditions.
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